Prevalence and Incidence of Type 1 Diabetes in the World DOI Creative Commons
Morteza Ghojazadeh, Majid Mobasseri, Fatemeh Pournaghi Azar

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Type 1 diabetes (T1D) is an autoimmune disease. The global prevalence of T1D estimated to range from 0.8 4.6 per 1000 population. In most cases, the higher, at 1–1.5 1000. terms incidence, variations have been noted based on geographical location, ethnicity, diagnostic criteria, birth season, age, and gender. Additionally, disease incidence exhibits differences across specific age groups between sexes. this condition higher among children than adults. highest occurs within 10–14-year group, followed by a gradual decline in as individuals age. 2021, approximately 6% adults reported receiving physician’s diagnosis diabetes. It notable that physician-diagnosed more prevalent men (7%) women (5%). Furthermore, it clear increases with under 35, 1%. aged 75 older, 16%. There growing worldwide. Insulin scarcity its associated high costs will disproportionately affect underdeveloped developing nations. Consequently, becomes imperative for international organizations individual countries proactively implement preventive measures response these concerning trends.

Language: Английский

Fifty years of HLA-associated type 1 diabetes risk: history, current knowledge, and future directions DOI Creative Commons
Janelle A. Noble

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 12, 2024

More than 50 years have elapsed since the association of human leukocyte antigens (HLA) with type 1 diabetes (T1D) was first reported. Since then, methods for identification HLA progressed from cell based to DNA based, and number recognized variants has grown a few tens thousands. Current genotyping methodology allows exact all HLA-encoding genes in an individual's genome, statistical analysis evolving digest enormous amount data that can be produced at astonishing rate. The region genome been repeatedly shown most important genetic risk factor T1D, original reported associations replicated, refined, expanded. Even remarkable progress through over 5,000 reports, comprehensive understanding effects on T1D remains elusive. This report represents summary field as it evolved stands now, enumerating many past present challenges, suggests possible paradigm shifts moving forward future studies hopes finally ways which influences pathophysiology T1D.

Language: Английский

Citations

2
Deciphering the Genetic Landscape: Exploring the Relationship Between HLA-DQA1, HLA-DQB1, and HLA-DRB1 Genes in Diabetes Mellitus DOI
Kuldeep Singh, Jeetendra Kumar Gupta, Dilip Kumar Chanchal

et al.

Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine, Journal Year: 2024, Volume and Issue: 21(3), P. 125 - 135

Published: Aug. 28, 2024

Diabetes mellitus (DM) is a complex and multifactorial metabolic disorder with significant genetic component. The human leukocyte antigen (HLA) genes, specifically HLA-DQA1, HLA-DQB1, HLA-DRB1, have been implicated in the susceptibility pathogenesis of DM. This review delves into intricate interplay these HLA seeking to unravel tapestry that contributes development progression diabetes. We begin by providing an overview system its critical role immune regulation. Subsequently, we explore current state knowledge regarding association between HLADRB1 polymorphisms both type 1 2 Emphasis placed on recent advancements research methodologies, including genomewide studies next-generation sequencing, provided deeper insights architecture also scrutinizes functional implications specific alleles modulating responses potential mechanisms which they contribute autoimmune processes observed Additionally, examine genes context insulin resistance beta-cell dysfunction diabetes, shedding light shared distinct underpinnings two major forms Furthermore, discuss clinical genotyping predicting disease risk, prognosis, personalized treatment strategies. integration information practice holds promise for precision medicine approaches diabetes management.

Language: Английский

Citations

0
Exploring the Connection Between HLA Class I and Class II Genotypes and Diabetic Retinopathy: A Comprehensive Review of Experimental Evidence DOI
Zahra Souri, Hamid Ahmadieh

Experimental Eye Research, Journal Year: 2024, Volume and Issue: 248, P. 110112 - 110112

Published: Sept. 24, 2024

Language: Английский

Citations

0
Prevalence and Incidence of Type 1 Diabetes in the World DOI Creative Commons
Morteza Ghojazadeh, Majid Mobasseri, Fatemeh Pournaghi Azar

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Type 1 diabetes (T1D) is an autoimmune disease. The global prevalence of T1D estimated to range from 0.8 4.6 per 1000 population. In most cases, the higher, at 1–1.5 1000. terms incidence, variations have been noted based on geographical location, ethnicity, diagnostic criteria, birth season, age, and gender. Additionally, disease incidence exhibits differences across specific age groups between sexes. this condition higher among children than adults. highest occurs within 10–14-year group, followed by a gradual decline in as individuals age. 2021, approximately 6% adults reported receiving physician’s diagnosis diabetes. It notable that physician-diagnosed more prevalent men (7%) women (5%). Furthermore, it clear increases with under 35, 1%. aged 75 older, 16%. There growing worldwide. Insulin scarcity its associated high costs will disproportionately affect underdeveloped developing nations. Consequently, becomes imperative for international organizations individual countries proactively implement preventive measures response these concerning trends.

Language: Английский

Citations

0