Infectious Disease Reports,
Journal Year:
2023,
Volume and Issue:
15(6), P. 758 - 765
Published: Dec. 10, 2023
Data
regarding
the
relationship
between
coronavirus
disease
(COVID-19)
and
active
or
latent
tuberculosis
(TB)
are
discordant.
We
conducted
a
retrospective
study
examining
impact
of
infection
(LTBI)
on
clinical
progression
COVID-19
patients.
selected
213
patients
admitted
with
in
tertiary-level
Italian
hospital
(February-December
2020),
who
underwent
QuantiFERON-TB
test
(QFT)
and/or
chest
radiological
exam.
The
population
was
divided
into
three
groups:
(i)
QFT
negative
without
TB
sequelae
(Neg);
(ii)
positive
(Pos);
(iii)
regardless
result
(Seq).
In-hospital
mortality
oro-tracheal
intubation
(OTI)
showed
significantly
higher
results
Seq
group
(Seq
50%
vs.
Pos
13.3%
Neg
9.3%,
p
<
0.001;
16.7%
6.7%
4.9%,
=
0.045).
Considering
groups'
as
defined
LTBI,
in-hospital
(20/51,
39.2%)
OTI
risk
(7/51,
13.7%)
were
statistically
respect
to
LTBI
(in-hospital
mortality:
15/162,
risk:
8/162,
0.023),
respectively.
Multivariate
analysis
that
Charlson
Comorbidity
Index
(CCI)
associated
rate;
despite
CCI
population,
we
cannot
exclude
correlation
presence
sequelae.
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(11), P. 2810 - 2810
Published: Nov. 19, 2023
Many
studies
have
focused
on
SARS-CoV-2
and
Mycobacterium
tuberculosis
(Mtb)
co-infection
consequences.
However,
after
a
vaccination
plan
against
COVID-19,
the
cases
of
severe
disease
death
are
consistently
controlled,
although
asymptomatic
mild
COVID-19
still
happen
together
with
(TB)
cases.
Thus,
in
this
context,
we
sought
to
compare
T
cell
response
COVID-19-non-vaccinated
-vaccinated
patients
active
exposed
antigens.
Flow
cytometry
was
used
analyze
activation
markers
(i.e.,
CD69
CD137)
cytokines
(IFN-γ,
TNFα,
IL-17,
IL-10)
levels
CD4+
CD8+
cells
upon
exposure
peptides.
The
data
obtained
showed
that
from
non-vaccinated
TB
present
high
frequency
TNF-α
viral
challenge
compared
vaccinated
donors.
Conversely,
show
IL-10
spike
peptide
stimulus
patients.
No
differences
were
observed
other
parameters
analyzed.
results
suggest
reduced
immune
balance
coinfected
individuals
may
consequences
for
pathogen
control,
necessitating
further
research
understand
its
impact
clinical
outcomes
those
concurrent
Mtb
infections.
Infectious Disease Reports,
Journal Year:
2023,
Volume and Issue:
15(6), P. 758 - 765
Published: Dec. 10, 2023
Data
regarding
the
relationship
between
coronavirus
disease
(COVID-19)
and
active
or
latent
tuberculosis
(TB)
are
discordant.
We
conducted
a
retrospective
study
examining
impact
of
infection
(LTBI)
on
clinical
progression
COVID-19
patients.
selected
213
patients
admitted
with
in
tertiary-level
Italian
hospital
(February-December
2020),
who
underwent
QuantiFERON-TB
test
(QFT)
and/or
chest
radiological
exam.
The
population
was
divided
into
three
groups:
(i)
QFT
negative
without
TB
sequelae
(Neg);
(ii)
positive
(Pos);
(iii)
regardless
result
(Seq).
In-hospital
mortality
oro-tracheal
intubation
(OTI)
showed
significantly
higher
results
Seq
group
(Seq
50%
vs.
Pos
13.3%
Neg
9.3%,
p
<
0.001;
16.7%
6.7%
4.9%,
=
0.045).
Considering
groups'
as
defined
LTBI,
in-hospital
(20/51,
39.2%)
OTI
risk
(7/51,
13.7%)
were
statistically
respect
to
LTBI
(in-hospital
mortality:
15/162,
risk:
8/162,
0.023),
respectively.
Multivariate
analysis
that
Charlson
Comorbidity
Index
(CCI)
associated
rate;
despite
CCI
population,
we
cannot
exclude
correlation
presence
sequelae.
