Colliding Challenges Part 2: An Analysis of SARS-CoV-2 Infection in Patients with Extrapulmonary Tuberculosis Versus SARS-CoV-2 Infection Alone DOI Creative Commons
Camil Mihuta, Adriana Socaci, Patricia Hogea

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 2071 - 2071

Published: Dec. 16, 2024

Background and Objectives: Coinfection with SARS-CoV-2 extrapulmonary tuberculosis (extraPTB) presents unique clinical challenges due to dual inflammatory responses potential differences in patient profiles compared those infection alone. This study uniquely contributes the underexplored interaction between extraPTB SARS-CoV-2, focusing on systemic inflammation as a critical determinant of outcomes. Materials Methods: retrospective, cross-sectional included 123 patients aged 19–91 years, hospitalized at Victor Babeș Hospital Timișoara from March 2020 2022. We 23 coinfected 100 age-matched SARS-CoV-2-only patients. Clinical records were examined for demographic, clinical, laboratory data. Results: The group was younger, 65% under 40 presented significantly higher IL-6, PCT, transaminase levels. Coexisting COPD type 2 diabetes independent predictors coinfection. A SpO2 diagnosis positively associated coinfection likelihood (OR = 5.37), while CT scores indicated less pulmonary involvement Non-fatal outcomes more frequent (95.7% sensitivity), only one had fatal outcome versus 17 group. Low elevated IL-6 significant mortality, severe symptoms tripling fatality odds. Conclusions: is younger age, heightened inflammation, longer hospital stays but does not increase mortality risk These findings underscore importance monitoring markers developing tailored management strategies improve long-term care patients, especially resource-limited settings.

Language: Английский

The interplay of tuberculosis and COVID-19: Insights into global health challenges DOI
Kirtimaan Syal

Journal of Biosciences, Journal Year: 2025, Volume and Issue: 50(1)

Published: Feb. 22, 2025

Language: Английский

Citations

0
Comparative Insights into COVID-19 and Tuberculosis: Clinical Manifestations, Inflammatory Markers, and Outcomes in Pulmonary Versus Extrapulmonary Tuberculosis and SARS-CoV-2 Co-Infection DOI Open Access
Camil Mihuta, Adriana Socaci, Patricia Hogea

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2782 - 2782

Published: April 17, 2025

Background: Tuberculosis and COVID-19 co-infection poses significant clinical challenges, with pulmonary TB (PTB) extrapulmonary (extraPTB) potentially influencing disease progression outcomes differently. This study aims to compare the manifestations, inflammatory markers, between PTB extraPTB patients SARS-CoV-2 co-infection. Methods: A retrospective, cross-sectional was conducted on 55 hospitalized adults TB-COVID-19 from March 2020 2022. Patients were divided into (n = 32) 23) groups. Demographic, clinical, laboratory, imaging data collected analyzed using statistical models, including ANCOVA, LASSO regression, Random Forest classification, identify key predictors of hospitalization duration mortality. Results: had significantly lower BMI, worse oxygenation status, greater lung involvement CT compared patients. CRP elevated in PTB, while IL-6 levels higher extraPTB. Hospitalization primarily influenced by coagulation markers (IL-6, D-dimer, neutrophil count, systemic index), BMI associated shorter stays. Mortality risk strongly correlated impairment (worst SpO2, SpO2 at diagnosis), burden (CRP, LDH), severity score, rather than localization. Conclusions: localization did not independently affect or mortality risk. Instead, severe involvement, inflammation, hypoxemia strongest poor outcomes. These findings emphasize importance early stratification based respiratory optimize patient management. Further research is needed clarify long-term impact co-infection, particularly cases.

Language: Английский

Citations

0
Clinical and immunologic features of co-infection in COVID-19 patients, along with potential traditional Chinese medicine treatments DOI Creative Commons
Guochao Zhang, Junjun Zhang, Qi Gao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 21, 2024

With the increasing number of people worldwide infected with SARS-CoV-2, likelihood co-infection and/or comorbidities is rising. The impact these co-infections on patient's immune system remains unclear. This study aims to investigate immunological characteristics secondary infections in hospitalized COVID-19 patients, and preliminarily predict potential therapeutic effects traditional Chinese medicine their derivatives for treatment co-infections. In this retrospective cohort study, we included 131 patients laboratory-confirmed COVID-19, whom there were 64 mild 67 severe cases. We analyzed clinical immunologic data, including circulating cell numbers, levels inflammatory factors viral load, comparing without co-infection. Among 41 (31.3%) positive, 33 (80.5%) having disease 14 (34.1%) them resulting fatalities. Co-infected exhibited significantly higher severity mortality rates compared non-co-infected counterparts. had lower absolute counts lymphocytes, total T CD4+ cells, CD8+ cells B while hs-CRP, PCT IL-6 elevated patients. Additionally, load co-infected was than Co-infection emerges as a dangerous factor elevating risk pneumonia mortality. suppresses host's response by reducing lymphocytes inflammation, thereby diminishing antiviral anti-infective system, which promotes disease. Therefore, it crucial implement infection prevention measures minimize spread among changes biomarkers provide theoretical basis effective medicine.

Language: Английский

Citations

3
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication DOI Open Access
Paul J. Baker, Andrea C. Bohrer, Ehydel Castro

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 27, 2024

SARS-CoV-2 infection leads to vastly divergent clinical outcomes ranging from asymptomatic fatal disease. Co-morbidities, sex, age, host genetics and vaccine status are known affect disease severity. Yet, how the inflammatory milieu of lung at time exposure impacts control viral replication remains poorly understood. We demonstrate here that immune events in mouse closely preceding significantly impact we identify key innate pathways required limit replication. A diverse set pulmonary stimuli, including resolved antecedent respiratory infections with

Language: Английский

Citations

2
Protective interplay: Mycobacterium tuberculosis diminishes SARS-CoV-2 severity through innate immune priming DOI Creative Commons

Brittany D. Williams,

Debora Ferede,

Hazem F. M. Abdelaal

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 20, 2024

At the beginning of COVID-19 pandemic those with underlying chronic lung conditions, including tuberculosis (TB), were hypothesized to be at higher risk severe disease. However, there is inconclusive clinical and preclinical data confirm specific SARS-CoV-2 poses for millions individuals infected Mycobacterium (M.tb). We others have found that compared singly mice, mice co-infected M.tb leads reduced severity alone. Consequently, a large interest in identifying molecular mechanisms responsible infection observed co-infection. To address this, we conducted comprehensive characterization co-infection model performed mechanistic vitro modeling dynamically assess how innate immune response induced by restricts viral replication. Our study has successfully identified several cytokines induce upregulation anti-viral genes epithelial cells, thereby providing protection prior challenge SARS-CoV-2. In conclusion, our offers understanding key pathways an existing bacterial effectively activity identifies candidate therapeutic targets infection.

Language: Английский

Citations

2
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication DOI Open Access
Paul J. Baker, Andrea C. Bohrer, Ehydel Castro

et al.

Science Immunology, Journal Year: 2024, Volume and Issue: 9(102)

Published: Dec. 6, 2024

Severity of COVID-19 is affected by multiple factors; however, it not understood how the inflammatory milieu lung at time SARS-CoV-2 exposure affects control viral replication. Here, we demonstrate that immune events in mouse closely preceding infection affect and identify innate pathways limit Pulmonary stimuli including resolved, antecedent respiratory infections with Staphylococcus aureus or influenza, ongoing pulmonary Mycobacterium tuberculosis infection, ovalbumin/alum-induced asthma, airway administration TLR ligands recombinant cytokines all establish an antiviral state restricts In addition to type I interferons, TNFα IL-1 potently precondition for enhanced control. Our work shows may benefit from immunologically quiescent microenvironment suggests heterogeneity inflammation contribute variability disease outcomes.

Language: Английский

Citations

2
SARS‐CoV‐2 coinfection in children with severe airway obstruction due to pulmonary tuberculosis DOI Creative Commons
Pierre Goussard, Lizelle Van Wyk, Shyam Sunder B. Venkatakrishna

et al.

Pediatric Pulmonology, Journal Year: 2024, Volume and Issue: 59(12), P. 3446 - 3456

Published: Aug. 26, 2024

Abstract Introduction The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic had a significant impact on tuberculosis (TB) control globally, with the number of new TB diagnoses decreasing. Coinfection some viruses, especially measles, could aggravate in children. This is presumably result depressed cellular immunity. Reports children and SARS‐CoV‐2 coinfection are limited. Methods A retrospective analysis up to 13 years old admitted Tygerberg Hospital, Cape Town, South Africa, from March 2020 December 2022 suspected TB‐induced airway compression requiring bronchoscopy. Children were included if they presented intrathoracic obstruction and/or radiographic evidence complicated TB. patients divided into two groups based polymerase chain reaction results. Demographics, exposure, microbiology, laboratory data, imaging, inflammatory cytokine levels, bronchoscopy data collected. Statistical analyses compared positive negative groups. Results Of 50 undergoing for obstruction, 7 (14%) positive. Cough was more prevalent group ( p = 0.04). There no difference culture yield between However, showed slower radiological improvement at 1 month 0.01), pleural effusions < 0.001), higher need endoscopic enucleation 0.001). FDG PET/CT scans indicated an ongoing inflammation group. Conclusions appears complicate disease course, necessitating medical interventions demonstrating longer duration process. Further research needed understand viral infections progression outcomes pediatric patients.

Language: Английский

Citations

1
Aspectos biológicos e clínicos da coinfecção tuberculose e COVID-19: uma revisão sistemática DOI Creative Commons

Juliana Silva de Santana,

Irapuan Oliveira Pinheiro, Ulísses Ramos Montarroyos

et al.

Contribuciones a las Ciencias Sociales, Journal Year: 2024, Volume and Issue: 17(1), P. 8242 - 8255

Published: Jan. 31, 2024

A Covid-19 é uma doença infecciosa altamente contagiosa e potencialmente perigosa que pode ser assintomática ou sintomática, a depender da resposta imunológica do hospedeiro contra o SARS-CoV-2. Paralelamente, tuberculose continua como um problema de saúde pública negligenciado também apresenta alta morbimortalidade, caso não seja tratada adequadamente. Ainda há muito explorado sobre coinfecção com ambas as doenças, por isso este artigo explorou os principais aspectos biológicos clínicos Covid-19, visto são informações essenciais para compreensão adoção medidas prevenção controle. Assim sendo, estudo se trata revisão sistemática foi construída através levantamento artigos publicados no período março 2020 dezembro 2023, tuberculose, nas bases dados SCIELO, BVS Pubmed. Foram utilizados descritores Vírus SARS-CoV-2, Mycobacterium tuberculosis coinfecção, sendo encontrados 79 excluídos 45. No geral, observou-se sintomas mais presentes na SARS-CoV-2 M. foram febre, dispneia tosse, ambos patógenos podendo invadir qualquer dos sistemas hospedeiro, justifica ampla variedade quadros desfechos. Com relação aos biológicos, causa estado inflamatório sistêmico desregulação imune caracteriza principalmente tempestade citocinas depleção células patógenos, em conjunto torna letal.

Citations

0
Diverse interactions of Mycobacterium tuberculosis infection and of BCG vaccination with SARS-CoV-2 DOI Creative Commons
Padmini Salgame,

Sri Ram Pentakota,

John Carlo M. Malabad

et al.

Frontiers in Tuberculosis, Journal Year: 2024, Volume and Issue: 2

Published: April 23, 2024

The COVID pandemic and tuberculosis (TB) endemicity is double trouble to much of the world. SARS-CoV-2 Mycobacterium (Mtb), causative agents TB, respectively, are both infectious respiratory pathogens involving close communities individuals. Both can cause lung disease, unbalanced inflammatory cell immune responses that lead a syndemic impact. Moreover, dual infection common in certain settings. In low- middle- income countries, most individuals with or COVID-19, fact, will have been exposed infected Mtb some develop active TB. Here we review literature examining diverse interactions M. BCG vaccination SARS-CoV-2. We discuss areas which contradictory results published conclude there still several unresolved issues warrant further study on co-pathogenesis BCG- mediated heterologous protection against COVID-19.

Language: Английский

Citations

0
Study of the results of Tuberculosis Interferon-Gamma Release Assays before and after the SARS CoV-2 pandemic DOI
A. Jerbi, S. Feki, L. Chtourou

et al.

Indian Journal of Tuberculosis, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Language: Английский

Citations

0