Impacts of environments on school myopia by spatial analysis techniques in Wuhan DOI Creative Commons
Qi Cui,

Yishuang Xu,

Fan Li

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 2, 2024

The prevalence of myopia in China has increased significantly recent years, and the age onset become younger. Previous studies have indicated that various environmental factors can influence development school myopia. However, impacts on remains to be investigated. Discoveries this field may contribute better urban planning. This study involved 7,610 students (aged 6–12 4084 boys 3526 girls) from six primary schools Wuhan, China. We evaluated associations between environment by analyzing geographical distribution myopic children. utilized spatial statistical analysis model. Normalized Difference Vegetation Index (NDVI) risk coefficient for a 5,000-m radius around target was 0.379 (p = 0.008), while NDVI 100-m 0.241 0.047). sports area 0.234 0.016). found specific buffers were associated with schools, which worth further research guide future initiatives an perspective.

Language: Английский

The role of transforming growth factor beta in myopia development DOI
Hsiangyu Ku, Jamie Jiin-Yi Chen, Wei Chen

et al.

Molecular Immunology, Journal Year: 2024, Volume and Issue: 167, P. 34 - 42

Published: Feb. 10, 2024

Language: Английский

Citations

4
An Evidence-Based Narrative Review of Scleral Hypoxia Theory in Myopia: From Mechanisms to Treatments DOI Open Access
Xiao Qin,

Xiang Zhang,

Zhanglin Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 332 - 332

Published: Jan. 2, 2025

Myopia is one of the dominant causes visual impairment in world. Pathological myopia could even lead to other serious eye diseases. Researchers have reached a consensus that be caused by both environmental and genetic risk factors. Exploring pathological mechanism can provide scientific basis for developing measures delay progression or treat it. Recent advances highlight scleral hypoxia an important factor promoting myopia. In this review, we summarized role pathology also provided interventions target directly indirectly. We hope review will aid development novel therapeutic strategies drugs

Language: Английский

Citations

0
Exploring Associations between Dual Sensory Impairment and Neuropsychiatric Disorders: Insights from a Prospective Cohort Study in the UK Biobank DOI
Haihua Guo, Wei Zhang,

Shuang-Ling Han

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring Molecular Pathways in Refractive Errors Associated with Inherited Retinal Dystrophies DOI Creative Commons
Fabiana D’Esposito, Caterina Gagliano, Alessandro Avitabile

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(2)

Published: Feb. 18, 2025

The term inherited retinal dystrophies (IRDs) refers to a diverse range of conditions characterized by dysfunction, and mostly deterioration, leading gradual decay the visual function eventually total vision loss. IRDs have global impact on about 1 in every 3000 4000 individuals. However, prevalence statistics might differ significantly depending exact type dystrophy demographic being examined. cellular pathophysiology genetic foundation been extensively studied, however, knowledge regarding associated refractive errors remain limited. This review aims clarify molecular processes that underlie IRDs. We did thorough search current literature (Pubmed, accession Feb 2024), selecting works describing phenotypic differences among genes-related IRDs, particularly relation errors. First, we summarize wide their causes, genes biological pathways connected etiology disease. then explore complex relationship between including how impairment vision-related mechanisms retina can affect ocular biometry optical characteristics. New data involvement aberrant signaling pathways, photoreceptor degeneration, dysfunctional pigment epithelium (RPE) development also discuss therapeutic implications defects individuals with IRD, possible approaches treating impairments. In addition, address value using cutting-edge imaging methods animal models examine linked suggest future lines inquiry for identifying new targets treatment. summary, this study presents an integrated understanding underlying It illuminates intricacies phenotypes these offers tool isolated errors, besides IRD-related forms.

Language: Английский

Citations

0
Advances in understanding the role and mechanism of the cGAS-STING signaling pathway in ocular diseases DOI Creative Commons
Mengdi Zhang, Jiayu Xu,

Wenjia Qu

et al.

Immunological Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: March 8, 2025

The cGAS-STING signaling pathway plays a critical role in the immune defense against DNA viruses and autoimmunity, coordinating cascade of events that enhance cytokine production, particularly type I interferons. This review summarizes recent advancements understanding pathway's impact on various ocular diseases, including age-related macular degeneration (AMD), diabetic retinopathy, uveitis. Activation this by cytoplasmic from either damaged retinal cells or external pathogens induces inflammatory responses may accelerate disease progression. Moreover, paper explores new therapeutic approaches target pathway, offering insights into how modulation could reduce inflammation improve clinical outcomes. emerging research area suggests potential for innovative treatments degenerative conditions.

Language: Английский

Citations

0
Causal effects of allergic diseases on the risk of myopia: a two-sample Mendelian randomization study DOI

X.X. Wei,

Weitao Li,

Rong Liu

et al.

Eye, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

Citations

0
The Role of circFAM53B in Regulating Choroidal Vascular Function in Pathological Myopia DOI Creative Commons
Meng Guan,

Boyong Zhang,

Wenjing Wu

et al.

Current Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 25, 2025

Purpose Myopia has reached epidemic levels worldwide, in which pathological myopia can lead to irreversible visual loss from associated ocular complications. This study aimed investigate the role of circular RNA circFAM53B choroidal dysfunction progression.

Language: Английский

Citations

0
Exploring associations between dual sensory impairment and neuropsychiatric disorders: insights from a prospective cohort study in the UK Biobank DOI
Haihua Guo, Wei Zhang,

Shuang-Ling Han

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 135, P. 105865 - 105865

Published: April 18, 2025

Language: Английский

Citations

0
Effect of Capsular Tension Ring Implantation on Postoperative Rotational Stability and Visual Performance of a Multifocal Toric Intraocular Lens DOI

Jiao Qi,

Xiaoxin Hu,

Wenwen He

et al.

Current Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8

Published: April 28, 2025

To investigate the effect of capsular tension ring (CTR) implantation on postoperative rotational stability and visual performance a plate-haptic multifocal toric intraocular lens in highly non-highly myopic eyes. Consecutive cataract patients intended for phacoemulsification IOL (AT LISA 909 M) were enrolled randomized to receive either co-implantation CTR or not. Axial length (AL) ≥ 26 mm was defined as (HM) At 3 months postoperatively, rotation degree, residual astigmatism, acuity, higher-order aberrations, modulation transfer function, dysfunctional index (DLI), quality vision (QVI) assessed. This prospective cohort study included 44 eyes with implanted 43 without. In HM eyes, group showed significantly smaller degree less astigmatism compared non-CTR group, however, no such differences found non-HM (both p > 0.05). Furthermore, despite difference exhibited lower spherical aberrations higher DLI QVI (all < 0.05), although observed Multivariate analysis identified longer AL, larger white-to-white, non-use independent risk factors greater rotation. The improves hence subsequently enhancing quality.

Language: Английский

Citations

0
Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study DOI Creative Commons
Yue Xu, Xing‐Xuan Dong, Yun Wang

et al.

Translational Vision Science & Technology, Journal Year: 2025, Volume and Issue: 14(5), P. 1 - 1

Published: May 1, 2025

This investigation aimed to elucidate the causal role of inflammatory cytokines in risk developing refractive errors. Genetic variants previously associated with served as instrumental variables genome-wide association studies (GWASs) European ancestry. Bidirectional two-sample Mendelian randomization (MR) analyses were conducted using summary data from GWAS meta-analyses. Rigorous sensitivity performed validate reliability MR results. We found that, for every unit increase interleukin 1 receptor antagonist (IL1RA) and 2 (IL2), there was a corresponding decrease prevalence myopic errors by 0.235 (95% confidence interval [CI], 0.050-0.419 fixed effects; 95% CI, 0.125-0.345 random effects) 0.132 0.032-0.231 0.044-0.220 effects), respectively. No substantial associations observed IL1α, IL1β, IL12p70, or monocyte chemoattractant protein (MCP1) Conversely, reverse failed indicate influence on IL1RA IL2. The present study offers evidence link between errors, which could have significant implications early detection, surveillance, management Our underscores importance IL2 prevention suggesting feasibility strategies identification, continuous deployment focused therapeutic approaches.

Language: Английский

Citations

0