The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117177 - 117177

Published: July 24, 2024

Cytokines regulate immune responses essential for maintaining homeostasis, as deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory disorders. The antioxidants emerge promising therapeutic agents because they mitigate oxidative stress and modulate pathways. Antioxidants potentially ameliorate inflammation-related disorders by counteracting excessive cytokine-mediated responses. A comprehensive understanding of pathways the interplay with is paramount developing natural targeting helping improve clinical outcomes enhance quality life patients. Among these antioxidants, curcumin, vitamin C, D, propolis, allicin, cinnamaldehyde have garnered attention their anti-inflammatory properties potential benefits. This review highlights interrelationship between cytokines-mediated in various diseases approaches involving antioxidants.

Language: Английский

---

Unveiling the role of functional foods with emphasis on prebiotics and probiotics in human health: A review

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 119, P. 106337 - 106337

Published: July 6, 2024

Functional foods particularly prebiotics and probiotics have attracted a lot of attention due to their ability alter gut microbiota an impact on number health disease-related factors, in relation human recent years. are that provide benefits beyond simple sustenance. They contain biologically active ingredients offer additional when consumed regular basis as part balanced diet. Prebiotics, which indigestible fibers specifically promote the growth activity beneficial bacteria, probiotics, live microorganisms upon consumption sufficient amount, shown great promise modifying composition function microbiota. The identified review problem involves clarifying precise impacts immune system function, composition, metabolic health, disease prevention. This emphasizes numerous advantages preserving balance microbiota, boosting immunity, enhancing parameters, reducing risk diseases. also insight advances formulation functional mitigating conditions synergy between prebiotics.

Language: Английский

---

The diagnostic role of the systemic inflammation index in patients with immunological diseases: a systematic review and meta-analysis

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 29, 2024

Abstract The identification of novel, easily measurable biomarkers inflammation might enhance the diagnosis and management immunological diseases (IDs). We conducted a systematic review meta-analysis to investigate an emerging biomarker derived from full blood count, systemic index (SII), in patients with IDs healthy controls. searched Scopus, PubMed, Web Science inception 12 December 2023 for relevant articles evaluated risk bias certainty evidence using Joanna Briggs Checklist Grades Recommendation, Assessment, Development, Evaluation Working Group system, respectively. In 16 eligible studies, had significantly higher SII when compared controls (standard mean difference, SMD = 1.08, 95% CI 0.75 1.41, p < 0.001; I 2 96.2%, moderate evidence). pooled area under curve (AUC) diagnostic accuracy was 0.85 (95% 0.82–0.88). subgroup analysis, effect size significant across different types ID, barring lupus erythematosus ( 0.20). further analyses, ID active disease vs. those remission (SMD 0.81, 0.34–1.27, 93.6%, AUC 0.74 0.70–0.78). Our study suggests that can effectively discriminate between subjects without disease. Prospective studies are warranted determine whether routine practice. (PROSPERO registration number: CRD42023493142).

Language: Английский

---

Inflammasome Molecular Insights in Autoimmune Diseases

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(4), P. 3502 - 3532

Published: April 18, 2024

Autoimmune diseases (AIDs) emerge due to an irregular immune response towards self- and non-self-antigens. Inflammation commonly accompanies these conditions, with inflammatory factors inflammasomes playing pivotal roles in their progression. Key concepts molecular biology, inflammation, mimicry are crucial understanding AID development. Exposure foreign antigens can cause potentially leading AIDs through triggered by cross-reactive epitopes. Molecular emerges as a key mechanism which infectious or chemical agents trigger autoimmunity. In certain susceptible individuals, autoreactive T B cells may be activated antigen resemblances between self-peptides. Chronic typically driven abnormal responses, is strongly associated pathogenesis. Inflammasomes, vital cytosolic multiprotein complexes assembled infections stress, activating processes macrophages. characterized prolonged tissue injury repair cycles, significantly damage tissues, thereby increasing the risk of AIDs. Inhibiting inflammasomes, particularly autoinflammatory disorders, has garnered significant interest, pharmaceutical advancements targeting cytokines showing promise management.

Language: Английский

---

Omega-3 fatty acids and the gut microbiome: a new frontier in cardiovascular disease prevention

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 25, 2025

Language: Английский

---

Periostin and rheumatic diseases: early insights from a systematic review and meta-analysis

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 7, 2025

Periostin regulates angiogenesis, inflammation, and fibrosis, key processes in the pathophysiology of rheumatic diseases (RDs). However, its association with RDs has not been assessed. We conducted a systematic review meta-analysis studies reporting circulating periostin RD patients healthy controls. searched electronic databases from inception to 30 November 2024 for relevant articles assessed risk bias certainty evidence using JBI critical appraisal checklist GRADE, respectively. In 12 eligible studies, there was non-significant trend towards higher concentrations (standard mean difference, SMD = 0.46, 95% CI -0.07 0.98, p 0.089; I2 94.2%, < 0.001). The results were stable sensitivity analysis. There no significant associations between age, male-to-female ratio, number participants, or publication year. we observed elevations investigating systemic sclerosis rheumatoid arthritis but osteoarthritis. Significant reductions ankylosing spondylitis dermatomyositis. Furthermore, America, Asia Europe. Our study suggests sclerosis. Such may reflect more pronounced dysregulation angiogenesis fibrosis when compared other RDs. Further research is warranted investigate wide range various inflammatory, angiogenic, fibrotic features whether useful diagnosis, prognosis, monitoring this patient group (PROSPERO registration number: CRD42024623501).

Language: Английский

---

Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 84 - 84

Published: Jan. 8, 2025

Traditionally, research on the adaptive immune system has focused protein antigens, but emerging evidence underscored essential role of lipid antigens in modulation. Lipid are presented by CD1 molecules and activate invariant natural killer T (iNKT) cells group 1 CD1-restricted cells, whereby they impact responses to pathogens tumors. Recent advances mass spectrometry, imaging techniques, lipidomics have revolutionized identification characterization enhanced our understanding their structural diversity functional significance. These advancements paved way for lipid-based vaccines immunotherapies through application nanoparticles synthetic designed boost against cancers infectious diseases. trafficking, molecule interactions, system's response yet be completely understood, particularly context autoimmunity microbial infections. In years come, continued efforts needed uncover its underlying biological mechanisms exploit full potential therapies directed antigens.

Language: Английский

---

Yoga Practice as a Potential Sarcopenia Prevention Strategy in Indonesian Older Adults: A Cross-Sectional Study

Open Access Journal of Sports Medicine, Journal Year: 2025, Volume and Issue: Volume 16, P. 3 - 13

Published: Jan. 1, 2025

Background: Sarcopenia is characterized by the progressive loss of skeletal muscle mass and poses a significant health challenge for older adults increasing risk disability decreasing quality life. Yoga considers as low-risk beneficial exercise adults. This research aims to evaluate potential yoga practice preventive strategy against sarcopenia in Indonesian Methods: An observational cross-sectional was conducted including 41 aged 60– 87 years. The focused on key biomarkers functional assessments, serum insulin-like growth factor 1 (IGF-1) levels, telomere length, gait speed, hand grip strength, SARC-F questionnaire scores. Results: results showed that participants 71– 80 years who practiced more than year had significantly higher IGF-1 levels (p=0.04). While improvements scores were observed, these changes not statistically significant, no differences found length. Conclusion: associated with upper lower extremity though findings did influence shows an emerging adjuvant option but can be applied single prevention Keywords: aging, frailty, life,

Language: Английский

---

The Effects of Yoga on the Mental Health of Individuals With Autoimmune Disorders: A Scoping Review

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Yoga has been explored as a health modality to maintain mental and physical complementary therapy for managing various medical conditions. It most recently researched its ability decrease inflammatory markers responsible ailments. This opens the door potential role an adjunct in inflammatory-led dysfunctions such autoimmune disorders. Although there robust amount of data on yoga conditions, previous reviews have mostly limited improvements that patients experience rather than changes. scoping review aims address effective choice treatment management options symptoms associated with The initial search revealed 211 relevant studies, but following extensive review, 11 articles were included final analysis. interventions ranged from six weeks up months Iyengar yoga, Hatha generalized practices did not fit into specific subtype. Eight analyzed multiple sclerosis, two focused rheumatoid arthritis one assessed irritable bowel disease. Between studies this key stress level, anxiety, sleep, self-efficacy, depression, emotional fatigue. Significant improvement was found all these subtypes. is viable, non-pharmaceutical both components

Language: Английский

---

Saturated fat in an evolutionary context

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 28, 2025

Evolutionary perspectives have yielded profound insights in health and medical sciences. A fundamental recognition is that modern diet lifestyle practices are mismatched with the human physiological constitution, shaped over eons response to environmental selective pressures. This Darwinian angle can help illuminate resolve issues nutrition, including contentious issue of fat consumption. In present paper, intake saturated ancestral contemporary dietary settings discussed. It shown while fatty acids been consumed by ancestors across time space, they do not feature dominantly diets hunter-gatherers or projected nutritional inputs genetic accommodation. higher high-fat dairy meat products produces a divergent acid profile increase risk cardiovascular inflammatory disease decrease overall satiating-, antioxidant-, nutrient capacity diet. By prioritizing fiber-rich micronutrient-dense foods, as well items proportion unsaturated acids, particular long-chain polyunsaturated omega-3 better aligned wild natural achieved. would prevent burdening diseases civilization, heart disease, cancer, neurodegenerative conditions. Saturated part balanced diet; however, caution warranted food environment differs markedly from one which we adapted.

Language: Английский

---