Otology & Neurotology,
Journal Year:
2024,
Volume and Issue:
45(8), P. 947 - 953
Published: July 29, 2024
Gentamicin
is
a
commonly
used
aminoglycoside
antibiotic,
with
ototoxicity
as
significant
side
effect.
Ferroptosis,
an
iron-dependent
form
of
cell
death,
has
been
implicated
in
variety
disorders.
Whether
ferroptosis
impacts
gentamicin
not
yet
known.
The
current
work
in-vitro
model
to
examine
the
influence
gentamicin-induced
on
cochlear
hair
damage
and
probable
molecular
biological
pathways.
Neuroreport,
Journal Year:
2025,
Volume and Issue:
36(6), P. 327 - 335
Published: March 26, 2025
Acute
cerebral
infarction
(CI)
is
characterized
by
acute
onset,
high
disability
rate,
and
morbidity
which
seriously
threatens
the
health
safety
of
people
places
a
heavy
burden
on
individuals
country.
This
study
aimed
to
explore
effects
butylphthalide
nerve
cell
ferroptosis
in
CI
rats
its
underlying
mechanisms.
Middle
artery
occlusion
(MCAO)
rat
model
was
used
effect
vivo
oxygen
glucose
deprivation
(OGD)
vitro
.
Our
findings
demonstrated
that
markedly
reduced
oxidative
damage
brains
MCAO
rats.
Furthermore,
we
found
upregulated
netrin-1/deleted
colorectal
cancer
(DCC)/vascular
endothelial
growth
factor
(VEGF)
signaling
axis,
regulates
NF-E2-related
factor-2
(NRF2)
expression
contributes
OGD-treated
HT22
cells.
Collectively,
our
indicate
inhibits
stress-mediated
cells
modulating
netrin-1/DCC/VEGF/NRF2
axis.
In
conclusion,
results
reveal
novel
mechanism
for
protection
CIs
butylphthalide.
Otology & Neurotology,
Journal Year:
2024,
Volume and Issue:
45(8), P. 947 - 953
Published: July 29, 2024
Gentamicin
is
a
commonly
used
aminoglycoside
antibiotic,
with
ototoxicity
as
significant
side
effect.
Ferroptosis,
an
iron-dependent
form
of
cell
death,
has
been
implicated
in
variety
disorders.
Whether
ferroptosis
impacts
gentamicin
not
yet
known.
The
current
work
in-vitro
model
to
examine
the
influence
gentamicin-induced
on
cochlear
hair
damage
and
probable
molecular
biological
pathways.
