Brain Research, Journal Year: 2024, Volume and Issue: unknown, P. 149353 - 149353
Published: Nov. 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1888 - 1888
Published: Feb. 4, 2024
The process of aging is accompanied by a dynamic restructuring the immune response, phenomenon known as immunosenescence. Further, damage to endothelium can be both cause and consequence many diseases, especially in elderly people. purpose this study was carry out immunological biochemical profiling people with acute ischemic stroke (AIS), chronic cerebral circulation insufficiency (CCCI), prediabetes or newly diagnosed type II diabetes mellitus (DM), subcortical vascular dementia (SIVD). Socio-demographic, lifestyle, cognitive data were obtained. Biochemical, hematological, analyses carried out, extracellular vesicles (EVs) endothelial CD markers assessed. greatest number significant deviations from conditionally healthy donors (HDs) same age registered SIVD group, total 20, which 12 specific six non-specific but maximal differences (as compared other three groups) HDs group. for MOCA (Montreal Cognitive Impairment Scale), MMSE (Mini Mental State Examination) life satisfaction self-assessment scores, decrease albumin levels, ADAMTS13 (a Disintegrin Metalloproteinase Thrombospondin Type 1 motif, member 13) activity, an increase VWF (von Willebrand factor) level. Considering changes parameters (mostly Th17-like cells) (CD144 CD34), repair impaired extent DM AIS patients showed HD controls, including These high NEFAs (non-esterified fatty acids) CD31 CD147 EVs. lowest CCCI nine total. There controls no specifics just one difference control parameters, α1-AGP (alpha acid glycoprotein, orosomucoid). Besides patients, impairments also complete absence such (SIVD group). On hand, microvascular seemed latter considering indicators ADAMTS13. In maximum response registered, mainly cells. reaction not pronounced groups may indicate initial stages and/or compensatory nature organic (remodeling). At time, indicated persistent remodeling microvessels, inflammation, anabolic function liver tissues. obtained support two interrelated assumptions. Taking into account primary factors that trigger pathological processes associated pathology related first assumption purine degradation skeletal muscle major factor production uric acid, followed its non-muscle cells, main are Another therapeutic levels progenitor cells have effect reducing risk cerebrovascular disease neurodegenerative diseases.
Language: Английский
Citations
9
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 115999 - 115999
Published: Dec. 12, 2023
The coronavirus disease 2019 (COVID-19) pandemic has affected the mental health of individuals worldwide, and risk psychiatric sequelae consequent disorders increased among general population, care workers patients with COVID-19. Achieving effective widespread prevention pandemic-related to protect global population is a serious challenge. Salidroside, as natural agent, substantial pharmacological activity effects, exerts obvious neuroprotective may be in preventing treating resulting from stress stemming COVID-19 pandemic. Herein, we systematically summarise, analyse discuss therapeutic effects salidroside treatment well its roles progression disorders, fully clarify potential widely applicable agent for caused by stress; mechanisms underlying protective are involved regulation oxidative stress, neuroinflammation, neural regeneration cell apoptosis brain, network homeostasis neurotransmission, HPA axis cholinergic system, improvement synaptic plasticity. Notably, this review innovatively proposes that stress-induced issues during provides scientific evidence theoretical basis use products combat current crisis.
Language: Английский
Citations
8
iScience, Journal Year: 2023, Volume and Issue: 27(1), P. 108688 - 108688
Published: Dec. 7, 2023
Language: Английский
Citations
4
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 18, 2024
While observational studies link immune cells with post-stroke functional outcome, the underlying mechanisms are not well understood. Immune cell surface antigens actively involved in biological behavior of cells, investigating could deepen our comprehension their role and processes stroke recovery. Therefore, we aimed to investigate immunological basis outcome by exploring causal relationship between after ischemic a Mendelian randomization study. Genetic variants related were selected for two-sample (MR) analysis. 389 fluorescence intensities (MFIs) included. Inverse variance weighted (IVW) modeling was used as primary MR method estimate effect exposure on followed several alternative methods sensitivity analyses. Additional analysis association risk assessment collider bias. We found that suggestive associations CD20 switched memory B (OR = 1.16, 95% CI: 1.01-1.34, p 0.036) PDL-1 monocyte 1.32, 1.04-1.66, 0.022) poor whereas CD25 CD39+ resting Treg 0.77, 0.62-0.96, 0.017) suggestively associated good outcome. The elevated cell, monocyte, may be novel biomarkers potential factors influencing
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3507 - 3507
Published: March 20, 2024
We reported that a 31-amino-acid Zfra protein (zinc finger-like regulates apoptosis) blocks neurodegeneration and cancer growth. binds WW domain-containing oxidoreductase (WWOX) to both N- C-termini, which leads accelerated WWOX degradation. limits the progression of such as Alzheimer’s disease (AD) by binding tau tau-hyperphosphorylating enzymes. Similarly, many targets accelerates their degradation independently ubiquitination. Furthermore, Zfra4-10 peptide strongly prevents AD-like symptoms in triple-transgenic (3xTg) mice during aging. restores memory loss 9-month-old 3xTg blocking aggregation cascade, including TPC6AΔ, TIAF1, SH3GLB2, causing amyloid β. also suppresses inflammatory NF-κB activation. Zfra-activated Hyal-2+ CD3- CD19- Z cells spleen, via Hyal-2/WWOX/Smad4 signaling, are potent suppression. In this perspective review, we provide mechanistic insights regarding how overrides induce suppression retard AD cells.
Language: Английский
Citations
1
Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15
Published: May 28, 2024
Objective Previous studies have not shown an association between IgD-CD24-B-cell absolute count (IgD-CD24-AC) and ischemic stroke (IS). Our study aimed to assess the causal effect of IgD-CD24-AC on IS explore role ascorbic acid 2-sulfate (AA2S) as a potential mediator. Methods was based largest available genome-wide (GWAS). Inverse variance weighting (IVW), MR–Egger, weighted median (WMN), simple mode, mode methods were used effects, with IVW primary outcome. Subsequently, we further performed two-step MR analysis evaluate whether AA2S mediated this effect. In addition, several sensitivity analyses conducted heterogeneity, including Cochran’s Q test, MR–Egger intercept MR-PRESSO global leave-one-out analysis. Results Using approach, risk ratio estimated be 1.216 (95% CI = 1.079–1.371, p 0.001). This result supported by WMN method (OR 1.204, 95% 1.020–1.421, 0.028) 1.177, 0.962–1.442, 0.133). We also observed same trend model model. Furthermore, proportion genetically predicted through levels 3.73%. Conclusion revealed relationship IS, small part which AA2S. These findings offer critical insights for developing immune-targeted therapies in future lay strong foundation advancements precision medicine.
Language: Английский
Citations
1
Biochemical and Biophysical Research Communications, Journal Year: 2023, Volume and Issue: 689, P. 149216 - 149216
Published: Nov. 10, 2023
Language: Английский
Citations
3
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Dec. 22, 2023
Abstract Anti-Leucine-rich glioma inactivated-1 (LGI1) and anti-contactin-associated-protein-2 (CASPR2) associated autoimmune encephalitis (AIE) variants are characterized by directly pathogenic autoantibodies present in serum CSF. The dynamics drivers of intrathecal systemic autoantibody production incompletely understood. We aimed to elucidate the immunologic basis LGI1-/CASPR2-associated AIE performing multi-omic profiling CSF/blood untreated patients. validated findings flow cytometry independent cohorts confirmed functionality using rodent immunization. identified clonal IgG2 IgG4 plasma cell expansion affinity maturation CSF together with clonally restricted, activated, antigen-experienced CD8 CD4 T cells as a hallmark these variants. Using recombinant cloning, we that expanded clones almost exclusively bound respective neuronal autoantigen. In addition, found loss regulatory mucosa-associated invariant (MAIT) gamma delta – lesser degree blood. functional role novel murine active immunization paradigm both autoantigens: MAIT suppressed formation LGI1 CASPR2-specific anti-neuronal antibodies. propose mechanisms mediated innate-like promote shared mechanism AIE. One sentence summary Cerebrospinal fluid (CSF) peripheral blood (PB) single transcriptomics patients anti-LGI1 anti-CASPR2 demonstrated specific autoantigen-specific T-cells (MAIT).
Language: Английский
Citations
3
Brain Research, Journal Year: 2023, Volume and Issue: 1825, P. 148724 - 148724
Published: Dec. 16, 2023
Language: Английский
Citations
2
Molecular & Cellular Toxicology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 14, 2024
Language: Английский
Citations
0