Expert Review of Vaccines, Journal Year: 2024, Volume and Issue: 23(1), P. 812 - 829
Published: Aug. 26, 2024
Cancer vaccines stimulate the activation of specific humoral and cellular adaptive responses against cancer cells.Antibodies generated post vaccination can be isolated further selected to develop highly potent monoclonal antibodies (mAbs) tumor-associated antigens.
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 18, 2024
The genesis and progression of tumors are multifaceted processes influenced by genetic mutations within the tumor cells dynamic interplay with their surrounding milieu, which incessantly impacts course cancer. microenvironment (TME) is a complex entity that encompasses not only but also an array non-cancerous cells, signaling molecules, extracellular matrix. This intricate network crucial in progression, metastasis, response to treatments. TME populated diverse cell types, including immune fibroblasts, endothelial alongside cytokines growth factors, all play roles either suppressing or fostering growth. Grasping nuances interactions vital for advancement targeted cancer therapies. Consequently, thorough understanding alterations identification upstream regulatory targets have emerged as research priority. NF-κB transcription central inflammation innate immunity, increasingly recognized significant role onset progression. review emphasizes influence pathway TME, underscoring its development By examining between various components targeting appears promising treatment approach.
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1851 - 1851
Published: Feb. 21, 2025
Receptors for the immunoglobulin G constant fraction (FcγRs) are widely expressed in cells of immune system. Complement-independent phagocytosis prompted FcγR research to show that engagement IgG complexes with FcγRs triggers a variety cell host responses, such as phagocytosis, antibody-dependent cytotoxicity, and NETosis, among others. However, variants these receptors have been implicated development susceptibility autoimmune diseases systemic lupus erythematosus. Currently, knowledge is required field antibody therapeutics, which includes engineering recombinant soluble human Fc gamma receptors, enhancing inhibitory blocking activating function, vaccines, organ transplantation. Importantly, recent interest enhancement (ADE), mechanism by pathogenesis certain viral infections enhanced. ADEs may be responsible severity SARS-CoV-2 infection. Therefore, become current topic. this review briefly describes some historical about type I family humans, including structure, affinity, ligand binding, erythematosus (SLE), potential therapeutic approaches related SLE.
Language: Английский
Citations
1
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 22, 2025
This review article explores the rapidly evolving field of bi-, tri-, and multi-specific NK cell engagers (NKCEs), highlighting their potential as a cutting-edge approach in cancer immunotherapy. NKCEs offer significant advancement over conventional monoclonal antibodies (mAbs) by enhancing Antibody-Dependent Cellular Cytotoxicity (ADCC). They achieve this stably selectively binding to both activating receptors tumor-associated antigens (TAAs). Unlike traditional mAbs, which depend on relatively transient interaction between Fc region CD16a, establish more robust connections with range (e.g., NKG2D, NKp30, NKp46, NKG2C) inhibitory Siglec-7) cells, thereby increasing killing efficacy specificity. critically examines strategies for engineering immunotherapy, providing an in-depth analysis latest advancements NKCE platform technologies currently under development pharmaceutical biotech companies discussing preclinical clinical progress these products. While show great promise, underscores need continued research optimize therapeutic overcome obstacles related functionality patients. Ultimately, presents overview current landscape future prospects NKCE-based emphasizing its revolutionize treatment.
Language: Английский
Citations
0
Methods in molecular biology, Journal Year: 2025, Volume and Issue: unknown, P. 65 - 78
Published: Jan. 1, 2025
Language: Английский
Citations
0
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)
Published: May 23, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: May 28, 2024
Natural killer (NK) cells are closely associated with malignant tumor progression and metastasis. However, studies on their relevance in colorectal cancer (CRC) limited. We aimed to comprehensively analyze the absolute counts, phenotypes, function of circulating NK patients CRC using multiparametric flow cytometry. The distribution cell subsets peripheral circulation was significantly altered relative control group. This is shown by decreased frequency count CD56dimCD16+ antitumor effects, contrary increased CD56bright CD56dimCD16- poor or ineffective effects. were functionally impaired, intracellular interferon (IFN)-γ secretion a lower percentage surface granzyme B perforin expression. In addition, IFN-γ expression stage progression. Based comprehensive analysis functional markers cells, we found an subset impaired CRC.
Language: Английский
Citations
3
Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4156 - 4156
Published: Dec. 13, 2024
Iron metabolism plays a dual role in cancer, serving as an essential nutrient for cellular functions and potential catalyst tumor growth immune evasion. Here, we cover the complex interplay between iron levels within serum or microenvironment cancer therapy, focusing on how deficiency overload can impact function, progression, treatment efficacy. On one hand, highlight factor of primary responses its adverse effects anti-cancer immunotherapy other also stress contributing to growth, creating suppressive that hinders checkpoint inhibitor immunotherapy. Overall, emphasize necessity personalized management oncology patients critical element optimization achieve favorable outcomes. Based these considerations, believe close careful monitoring tailored balancing supplementation strategies should be subject further clinical studies, routine implemented practice integrated into therapy protocols.
Language: Английский
Citations
3
Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(4), P. 1401 - 1417
Published: Sept. 18, 2024
Language: Английский
Citations
2
Published: July 9, 2024
Cancer cells are believed to be recognized and controlled by the immune system of host, especially adaptive system. Cancers may initiated a single gene defect in stem or regenerating during replacement old injured tissue cells, additional defect(s) then occur. To compensate for missing proteins intracellular homeostasis systems, such as proteostasis, work with activation new genes. The risk predisposing factors cancers related number cell renewals (the turnover time) probability defect(s). Oncological symptoms associated substances that derived from antigens expressed on cancer those damaged corresponding reactions. In patients other conditions, inadequate components control these result chronic inflammatory autoimmune diseases. communicate host including T survival proliferation need assistance against infections physicochemical insults. cell-based therapeutics have been developed clinically used some cancers, advanced cancers. We further discuss oncogenesis, pathophysiology unresolved issues tumor immunology reinterpret effectiveness therapies under protein-homeostasis-system hypothesis.
Language: Английский
Citations
1
World Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 15(3), P. 378 - 380
Published: March 22, 2024
Cancer immunotherapy is an effective with critical approaches in the treatment of oncological patients. Whilst numerous research and clinical trials are underway to develop endogenous approaches, it necessary focus on fundamental issues identify barriers basic progress. Addressing these challenges new pathways will require researchers clinicians join forces accelerate understanding complex interactions between cancer immune system resources developing better treatments for
Language: Английский
Citations
0