Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota DOI Creative Commons
Jing Li, Y. Xu, Tianhao Sun

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Nephrotic syndrome (NS) represents a prevalent among various chronic kidney disease pathologies and is known for its higher severity worse prognosis compared with glomerulonephritis. Understanding pathogenesis identifying more effective treatment modalities have long been concern of specialists. With the introduction gut-kidney axis concept progress in omics technologies, alterations gut microbiota observed primary secondary NS. This link has extensively researched conditions such as diabetic nephropathy immunoglobulin A (IgA) nephropathy. Thus, dysbiosis seen crucial contributing factor NS; however, there lack comprehensive reviews that elucidate changes across different NS describe mechanistic role disease. Moreover, serving an innate regulator microbiota, traditional Chinese medicine (TCM) potential to exert profound impact on expression inflammation-promoting agents, decreasing levels endotoxins uremic toxins. In addition, it strengthens stability intestinal barrier while controlling metabolic function body through efficient modulation microbiota. intricate process yields far-reaching consequences

Language: Английский

Causal Association between the Gut Microbiota and Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study in a Chinese Population DOI
Wenjian Lin, Zixin Liang,

Junxuan Fang

et al.

Published: Jan. 1, 2025

Background: Differences in the gut microbiota and related metabolites across populations may influence their causal relationship with chronic kidney disease (CKD), which remains unclear Chinese population.

Language: Английский

Citations

0
Association between dietary index for gut microbiota and chronic kidney disease: A cross-sectional study from U.S. population DOI Creative Commons
Xiaodong Zhou, Changchuan Jiang,

Byeng-Chun Song

et al.

Preventive Medicine Reports, Journal Year: 2025, Volume and Issue: unknown, P. 103060 - 103060

Published: April 1, 2025

Objective: Emerging evidence suggests that diet modulates gut microbiota, which in turn influences chronic kidney disease (CKD) progression. This study investigates the association between newly proposed Dietary Index for Gut Microbiota (DI-GM) and prevalence prognosis of CKD. Methods: cross-sectional analyzed data from U.S. National Health Nutrition Examination Survey 2007-2020. DI-GM scores were calculated based on dietary intake 14 food components, categorized as beneficial or unfavorable. Weighted linear regression model, logistic restricted cubic spline analysis used to assess associations with Results: The CKD among 28,512 participants was 17.4 %. Higher negatively associated (OR = 0.967, 95 %CI: 0.939-0.995, p 0.026) very high-risk 0.877, 0.821-0.937, < 0.001). Beneficial components significantly lower risk 0.928, 0.892-0.966, 0.001), while no significant observed unfavorable components. levels linearly improved (p trend <0.001). Coffee fiber primary contributors both CKD, whole grains primarily impacted its prognosis. Conclusions: DI-GM, driven by is reduced These findings suggest promoting patterns enhance microbiota may play a pivotal role management.

Language: Английский

Citations

0
Characterization of gut microbiota and metabolites in renal transplant recipients during COVID-19 and prediction of one-year allograft function DOI Creative Commons

Zijie Wang,

Xiang Gao,

Hongsheng Ji

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 10, 2025

Language: Английский

Citations

0
Causal associations between gut microbiota and premature rupture of membranes: a two-sample Mendelian randomization study DOI Creative Commons
Lei Zhang, Qian Li, Jiafeng Huang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 2, 2024

Background Previous study has indicated a potential link between gut microbiota and maternal pregnancy outcomes. However, the causal relationship premature rupture of membranes (PROM) remains topic ongoing debate. Methods A two-sample Mendelian Randomization (MR) was used to investigate PROM. Genetic data on obtained from MiBioGen consortium’s largest genome-wide association (GWAS) (n=14,306). PROM (3011 cases 104247 controls) were sourced publicly available GWAS Finnish National Biobank FinnGen consortium. Various methods including Inverse variance weighted (IVW), MR-Egger, simple mode, median, mode utilized assess by calculating odd ratio (OR) value confidence interval (CI). Sensitivity analyses for quality control performed using MR-Egger intercept tests, Cochran’s Q leave-one-out analyses. Results The IVW method revealed that class Mollicutes (IVW, OR=0.773, 95%CI: 0.61-0.981, pval = 0.034), genus Marvinbryantia OR=00.736, 0.555-0.977, Ruminooccaceae UCG003 OR=0.734, 0.568-0.947, 0.017) phylum Tenericutes 0.566-1.067, 0.034) associated with reduced risk PROM, while Collinsella OR=1.444, 1.028-2.026, Intestinibacter OR=1.304, 1.047-1.623, 0.018) Turicibacter OR=1.282, 1.02-1.611, 0.033) increased Based other four supplementary methods, six may have effect Due presence pleiotropy ( =0.045), Lachnoclostridium should be ruled out. No evidence horizontal or heterogeneity found in &gt; 0.05). Conclusions In this study, we discovered specific probiotics pathogens host identification through MR studies offers novel approach diagnosing treating condition, thereby providing new strategy clinically preventing

Language: Английский

Citations

1
Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota DOI Creative Commons
Jing Li, Y. Xu, Tianhao Sun

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Nephrotic syndrome (NS) represents a prevalent among various chronic kidney disease pathologies and is known for its higher severity worse prognosis compared with glomerulonephritis. Understanding pathogenesis identifying more effective treatment modalities have long been concern of specialists. With the introduction gut-kidney axis concept progress in omics technologies, alterations gut microbiota observed primary secondary NS. This link has extensively researched conditions such as diabetic nephropathy immunoglobulin A (IgA) nephropathy. Thus, dysbiosis seen crucial contributing factor NS; however, there lack comprehensive reviews that elucidate changes across different NS describe mechanistic role disease. Moreover, serving an innate regulator microbiota, traditional Chinese medicine (TCM) potential to exert profound impact on expression inflammation-promoting agents, decreasing levels endotoxins uremic toxins. In addition, it strengthens stability intestinal barrier while controlling metabolic function body through efficient modulation microbiota. intricate process yields far-reaching consequences

Language: Английский

Citations

0