Network pharmacology and gut microbiota insights: unraveling Shenling Baizhu powder’s role in psoriasis treatment

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 14, 2024

Background: Psoriasis, a chronic skin condition characterized by systemic inflammation and altered gut microbiota, has been target of Traditional Chinese Medicine (TCM) for centuries. Shenling Baizhu Powder (SLBZP), TCM formulation, holds promise treating inflammatory diseases, but its specific role in psoriasis impact on microbiota is not fully understood. Objective: This study aims to elucidate the mechanism SLBZP psoriasis, integrating component analysis, network pharmacology, experimental validation mice models. Methods: We commenced with detailed analysis using liquid chromatograph mass spectrometer (LC-MS). Network pharmacology was used predict potential action targets pathways psoriasis. An vivo experiment conducted models, treated SLBZP. Therapeutic effects were assessed via symptomatology, histopathology, immunohistochemical analysis. Gut composition analyzed 16S rRNA gene sequencing. Results: A total 42 main components quality markers identified, primarily from licorice ginseng, including flavonoids, saponins other markers. PPI topology showed that TNF, IL-6, IL-1β, TP53 JUN core DEPs. 168 signaling lipid atherosclerosis, AGE-RAGE pathway, IL-17 pathway Th17 cell differentiation enriched KEGG. demonstrated significant therapeutic mice, alterations pathology biomarkers. Additionally, notable changes observed post-treatment, indicating possible gut-skin axis involvement. Conclusion: research pinpointed metabolism as key treatment It explores how SLBZP’s modulation can alleviate suggesting balancing may reduce mediators offer benefits. underscores new strategy treatment.

Language: Английский

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CD8 + T cells may mediate the effect of gut microbiota on psoriasis: evidence from two-step mendelian randomization and bayesian weighting

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 8, 2025

Language: Английский

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Inhibition of PI3K/AKT/GLUT1 Signaling Pathway by Quercetin in the Treatment of Psoriasis

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(2)

Published: Feb. 21, 2025

Background: Psoriasis is an enduring inflammatory skin disorder defined by recurring attacks, distinguished primarily red patches and scaly skin. Quercetin, a kind of natural flavonoid compound, widely found in various vegetables, fruits, Chinese herbs. Quercetin multifaceted compound with wide range potential health benefits. In addition to antioxidant, cardiovascular protection, anti-tumor effects, quercetin has shown regulating immune inflammation effects. the initial stages, vivo studies have demonstrated that positively affects psoriasis connected phosphatidylinositol 3-kinase (PI3K)/Protein Kinase B (AKT)/glucose transporter 1 (GLUT1) signaling. Nevertheless, precise mechanism which influences PI3K/AKT/GLUT1 signaling cascade context remains uncertain. Objective: The aim this study was investigate therapeutic influence on relationship pathway. Methods: A mouse model for induced imiquimod employed assess alterations morphology lesions their histopathological characteristics. Cell Counting kit-8 (CCK-8) assay used impact proliferation HaCaT human keratinocyte cells. cells were examined using flow cytometry apoptosis. Additionally, Western blot analysis evaluate protein expression levels Results: concerning pathological alterations, mice group exhibited characteristic associated psoriasis. extent excessive keratinization epidermis hypertrophy spinous layer observed each dosage less pronounced compared group. CCK-8 laid out can suppress Furthermore, it facilitates apoptosis these Analysis immunoblotting intervention led modifications proteins related Conclusion: Through vitro experiments, shows may play role inhibit

Language: Английский

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Targeting Cytokine Dysregulation in Psoriasis: The Role of Dietary Interventions in Modulating the Immune Response

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2895 - 2895

Published: March 22, 2025

Psoriasis is a chronic immune-mediated skin disease characterized by cytokine dysregulation. Pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-17, and IL-23, play pivotal roles in the pathogenesis of psoriasis. Emerging evidence suggests that dietary interventions can modulate activity, providing complementary approach to standard therapies. This narrative review examines impact various strategies, Mediterranean diet, ketogenic gluten-free fasting-mimicking on profiles clinical outcomes Research insights reveal components such as omega-3 fatty acids, polyphenols, short-chain acids influence immune signaling pathways. These pathways include nuclear factor-kappa B (NF-κB) Signal Transducer Activator Transcription 3 (STAT3). Additionally, these promote anti-inflammatory effects mediated gut microbiota. Clinical studies demonstrate significant reductions psoriasis severity, improved quality life, modulation key cytokines associated with activity. Despite advancements, challenges persist effectively integrating findings into practice. variability patient responses, adherence issues, need for robust biomarkers monitor efficacy. Future directions emphasize potential personalized nutrition precision medicine approaches optimize tailored individual genetic predispositions. Integrating strategies care could transform treatment paradigms simultaneously addressing both systemic inflammation comorbid conditions.

Language: Английский

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L-Arginine and Immune Modulation: A Pharmacological Perspective on Inflammation and Autoimmune Disorders

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177615 - 177615

Published: April 1, 2025

Language: Английский

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Calcipotriol/Betamethasone Dipropionate for the Treatment of Psoriasis: Mechanism of Action and Evidence of Efficacy and Safety versus Topical Corticosteroids

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(15), P. 4484 - 4484

Published: July 31, 2024

The combined treatment with calcipotriol (Cal) and betamethasone dipropionate (BDP) has emerged as the leading anti-psoriatic topical treatment. Fixed-dose Cal/BDP is available in different formulations, including ointment, gel, foam, cream. This review examines mechanism of action underlying its therapeutic effect compiles evidence regarding efficacy safety compared to monotherapy corticosteroids. dual-action targets inflammatory pathways abnormal keratinocyte proliferation, both them fundamental mechanisms psoriasis pathogenesis. A large number randomized, double-blind studies support superiority over corticosteroids, demonstrating broad across several degrees severity capability provide early significant clinical improvements. increased achieved without negative effects on profile, since incidence adverse reported usually similar that BDP even lower than Cal alone. combination therapy rapid onset action, coupled a simplified dosing regimen, been identified crucial for improving long-term adherence patient outcomes. In conclusion, confirmed versatile, effective, convenient option management.

Language: Английский

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The therapeutic potential of polyunsaturated fatty acids in the management of inflammatory skin disorders

Quality in Sport, Journal Year: 2024, Volume and Issue: 16, P. 52652 - 52652

Published: July 9, 2024

Introduction and purpose: Polyunsaturated fatty acids (PUFAs) are a well-known component of nutritionally balanced diet. There is wealth evidence demonstrating that the ingestion these substances enhances health, as they involved in multitude metabolic processes essential for cellular functionality. However, contemporary Western diet distinguished by reduction consumption omega-3 polyunsaturated (PUFAs). The objective this review to present potential therapeutic efficacy PUFA supplementation most common inflammatory skin disorders, such acne vulgaris, atopic dermatitis psoriasis vulgaris. State knowledge: Acne vulgaris differ terms their pathophysiology. all characterised underlying processes. Omega-3 have been demonstrated possess anti-inflammatory properties. They capable modulating both innate adaptive immune responses, thereby alleviating symptoms aforementioned disorders. Summary: Given pluripotent qualities acids, it reasonable conclude become an effective tool management diseases.

Language: Английский

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Exploring the Link Between Psoriasis and Adipose Tissue: One Amplifies the Other

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13435 - 13435

Published: Dec. 15, 2024

Psoriasis and obesity, while distinct, are inter-related inflammatory conditions. Adipose tissue (AT)-derived mediators could be pathogenically active in triggering and/or amplifying psoriatic skin inflammation and, vice versa, drive increased adiposity that triggers the development of several chronic Gaining insight into their intricate relationship essential for effective management treatment. The aim this study was to determine (i) pathogenic role psoriasis-signature cytokines contributing AT metabolism (ii) AT-derived inflammation. For reason, firstly, whole treated with IL-17 TNF-α, alone or combination, investigate effects on expression production adipokines factors. TNF-α were able induce an additive synergistic effect mediators. In order assess inflamed by cytokines, ex vivo organ culture performed increase observed. These findings confirm psoriasis obesity amplify each other’s processes understanding mutual exacerbation lead more therapeutic strategies address both metabolism.

Language: Английский

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The Role of Metabolic Syndrome in Psoriasis Treatment Response: A One-Year Comparative Analysis of PASI Progression

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2887 - 2887

Published: Dec. 23, 2024

Background/Objectives: Psoriasis is a chronic dermatological condition with systemic implications, especially metabolic syndrome (MS). This study evaluated the vicious cycle where obesity and MS exacerbate inflammation that complicates efficacy of psoriasis therapies by examining PASI score over one-year period. Patients were classified into two subgroups: those alone (PSO) both (PSO-MS). Methods: A total 150 patients, half whom also concomitantly presented syndrome, received biologic comprising anti-IL-17, anti-IL-23, anti-TNF-a, or methotrexate, scores assessed at baseline 3, 6, 12 months. Results: All treatments showed significant reductions in PASI; however, patients PSO more marked than PSO-MS group. Anti-IL-17 produced greatest sustained long-term improvements, whereas anti-IL-23 prompt early improvements. Increases BMI leptin concentrations associated modest rate reduction score, underlining impact dysfunction on treatment efficacy. Conclusions: highlights importance managing comorbidities such as psoriasis, interplay between health further therapeutic outcomes.

Language: Английский

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Xiaoyin granules relieve skin lesions in mice with psoriasis through by EGFR-related pathway

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 20, 2024

Background: Psoriasis is a common relapsing chronic inflammatory skin disease, characterized by immune cell infiltration and abnormal proliferation of keratinocytes. Long-term clinical practice has shown that optimized Xiaoyin granules (XYKL) benefits for patients with mild to moderate psoriasis, there are no significant adverse reactions. However, the mechanism action not been fully deciphered. Objective: This study aims explore potential XYKL in treating psoriasis through network pharmacology experimental validation. Methods: The ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) technique was employed determine main components XYKL. Network molecular docking technology were utilized screen active components-targets-pathways Additionally, mouse model created based on predicted outcomes, both vivo vitro experiments conducted validate findings. Results: Through analysis, 22 effective ingredients 70 targets associated selected “compound-target” constructed relationship between compounds targets. PPI 26 including AKT1, STAT3, EGFR, SRC, ESR1, MMP9, KDR, GSK3B, IL2, MMP2 screened. Then, Gene ontology (GO) enrichment analysis Kyoto Encyclopedia Genes Genomes (KEGG) pathway “ingredient-target-pathway-disease” established these Finally, 10 important chemical from XYKL, which act 17 regulate 13 psoriasis-related biological pathways. In research models experiments, it found significantly inhibits levels mice may promote apoptosis human immortalized keratinocytes (HaCaT) inhibiting EGFR-related signaling their proliferation. Conclusion: confirmed therapeutic effect discovered achieve this alleviate response while also promoting apoptosis.

Language: Английский

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