Editorial: The impact of specific environmental exposures on breast, lung, and colon cancer: advancing public health strategies for enhanced outcomes
Frontiers in Public Health,
Journal Year:
2025,
Volume and Issue:
13
Published: Feb. 14, 2025
Cancer
remains
one
of
the
most
formidable
public
health
challenges,
with
breast,
lung,
and
colon
cancer
being
prevalent
deadly
types
worldwide[1,
2].
It
has
become
increasingly
clear,
that
aside
from
genetic
disposition,
lifestyle
choices
environmental
factors
have
a
profound
impact
on
increasing
an
individual's
risk
developing
cancer[3-6].
Exposure
to
harmful
agents—ranging
air
pollutants
toxic
chemicals—significantly
influences
incidence,
particularly
in
vulnerable
populations
[7].
To
effectively
combat
these
cancers
reduce
disparities
among
patients/survivors,
strategies
must
be
refined
address
risks,
improve
early
detection,
ensure
equitable
access
care.
This
Research
Topic
focuses
advancing
our
understanding
specific
exposures
implicated
cancer,
primarily
focusing
informing
strategies.
By
exploring
breakthrough
information
related
cancers,
we
seek
uncover
novel
insights
into
associations
between
their
carcinogenesis.The
relationship
incidence
is
well-documented,
yet
it
often
lacks
visibility
discourse.
Carcinogenic
substances
like
tobacco,
industrial
pollutants,
etc.
are
known
increase
for
cancers.
For
example,
prolonged
exposure
such
as
particulate
matter,
been
directly
linked
increased
lung
[8].
Similarly,
chemicals
found
pesticides
plastics
associated
breast
while
diet,
availability
processed
foods,
contribute
[9-11].
In
this
Topic,
several
studies
various
parts
world
well
United
States
present
evidence
growing
colon,
due
pollutants.
Godinho
dos
Santos
et
al.,
[12]
study,
showed
occupational
rural
working
women
induced
significant
changes
levels
cytokines
necessary
tumor
control
were
positively
correlated
worse
prognostic
outcomes.
A
meta-analysis
study
by
Liu
al.
[13]
demonstrated
endocrine-disrupting
(EDCs),
which
potential
interfere
function
normal
hormones,
cancer.
They
was
certain
EDC
congeners
metabolites,
benzene,
chlordane,
hexachlorocyclohexane,
polychlorinated
biphenyls.
Ying
[14]
conducted
prospective
cohort
determine
Bisphenol
(BPA)
mortality.
BPA,
phenol,
utilized
products,
including
baby
bottles,
food
containers
[15],
shown
detectable
more
than
90%
urine
samples
general
population
[16],
promoting
some
states
enforce
regulations
restrict
use
BPA.
The
authors
determined
lower
level
BPA
less
1.99
ng/mL
higher
scoping
review
military
(MEE)
volatile
organic
compounds
(VOCs),
tactile
herbicides,
airborne
hazards
open
burn
pits
(AHOBP),
depleted
uranium
service
members
Veterans,
Jester
[17]
MEE
poses
unique
veterans
who
affected
during
service.
However,
concede
further
needed
validate
findings
owing
mixed
limited
literature
veterans.
Socio-economic
demographics,
resulting
carcinogen
behavioral
physical
activity,
obesity,
or
substance
smoking
alcohol
consumption,
also
play
integral
roles
[18-21].
one-third
deaths
attributed
lack
another
third
tobacco
products
[22].
perspective
article,
Atchade
[23]
highlight
Westernized
dietary
patterns
contributor
impacting
colonic
microbiome
contributing
recent
surge
early-onset
CRC
(EOCRC).
correlation
caffeine
consumption
prevalence
Qu
[24]
applied
weighted
logistic
regression
National
Health
Nutrition
Examination
Survey
(NHANES)
dataset
evaluate
correlations.
dose–response
intake
levels.
continuation
previous
work
demonstrating
selectively
activates
mammalian
p38
mitogen-activated
protein
kinase
(MAPK)
cells,
current
Li
[25]
aimed
if
Pirfenidone
(PFD),
antifibrotic
compound
pharmacological
inhibitor
p38γ
MAPK,
could
inhibit
alcohol-induced
promotion
Their
results
demonstrate
PFD
successfully
inhibited
mammary
growth
alcohol-promoted
metastasis,
suggesting
agent,
currently
approved
treatment
idiopathic
pulmonary
fibrosis,
re-purposed
used
treat
aggressive
progression.
important
note
carcinogens
not
evenly
distributed
across
populations,
creating
inequity.
Studies
hazardous
non-air-pollutant-related
hazards,
water
contaminants
lead
[26],
greenspace
[27,
28],
poor
walkability
scores
[29,
30]
socially
and/or
economically
disadvantaged
[31-37].
An
assessment
differences
colorectal
(CRC)
survival
urban
areas
Fu
[38]
revealed
notable
difference
survival,
highlighting
importance
considering
urban–rural
prognosis
influence
socioeconomic
Higher
total
CRC-specific
mortality
rates
compared
areas.
Interestingly,
household
incomes
below
$75,000
$55,000
independent
overall
areas,
respectively.
identified
influencing
patients,
age
over
40
years,
male
gender,
black
ethnicity,
location
right
advanced
stages
(stage
III
stage
IV),
size
5
cm.
understand
installations
steel
plants,
oil
refineries
discharges,
etc.,)
two
articles
research
topic
regarding
correlations
residence
high
pressures
death
focus
female
characteristics
(Giannico
[39])
bronchus/lung
(Mincuzzi
[40])
Both
characteristics,
While
neither
able
clear
association
living
contaminated
site
national
interest
(SIN)
Taranto,
Italy,
they
did
find
residential
sites
all-cause
rate.
Mincuzzi
gender
poorly
differentiated
squamous-cell
carcinoma.
Finally,
Zhao
[41]
sort
Tracheal,
Bronchus,
Lung
(TBL)
greenspaces
(which
quality).
positive
green
spaces
TBL
individuals
aged
20
54.
summary,
suggests
spaces/forests
serve
protective
factors,
along
care
coverage,
better
status,
participation
activities.Despite
connection
efforts
mitigate
risks
insufficient.
especially
concerning
given
survivors
underserved
communities
frequently
face
outcomes
continued
hazards.
Addressing
requires
comprehensive
approach
targets
prioritizes
needs
populations.
Nolazco
[42]
cross-sectional
utilizing
self-reported
histories
39,578
participants
Behavioral
Risk
Factor
Surveillance
System
(BRFSS)
database,
former
smokers
exhibited
significantly
poorer
health-related
quality
life
(HRQoL)
when
never
smokers.
These
need
prioritize
cessation
survivors.
conjunction,
Tesfaw
[43]
systematic
assess
common
mortality-related
age,
stage,
comorbidities
cardiovascular
disease,
hypertension,
diabetes
nested
case-control
Xu
[44]
prior
history
chronic
bronchitis,
long-term
wheezing
symptoms,
smoking,
biofuel
combustion
obstructive
disease
(COPD).
Xiao
al.'s
[45]
investigating
epidemiological
healthcare
workers
Hunan
Province,
much
population.
Moreover,
exponentially
age.
article
highlights
faced
practitioners
medical
imaging
technicians,
implement
personal
safety
measures.Thus,
addressing
concerted
effort
governments,
officials,
providers,
communities.
strengthening
regulations,
justice,
enhancing
education,
investing
research,
integrating
healthcare,
can
advance
all.
fight
against
ongoing,
but
make
strides
toward
reducing
its
burden
improving
well-being
future
generations.In
conclusion,
time
now
proactive
causes
prioritizing
special
issue
within
broader
agenda,
move
closer
where
reduced,
all
opportunity
live
healthier
environments.
Language: Английский
Factors associated with recurrence in operable breast cancer patients undergoing surgery as the sole treatment modality
Acta Cirúrgica Brasileira,
Journal Year:
2025,
Volume and Issue:
40
Published: Jan. 1, 2025
ABSTRACT
Purpose:
Approximately
10%
of
breast
cancer
patients
with
localized
operable
disease
experience
recurrence.
This
study
aimed
to
evaluate
early-stage
(TNM
I
and
II)
who
underwent
surgery
without
the
need
for
neoadjuvant
therapy.
Methods:
The
total
117
was
included
in
study:
104
recurrence
13
We
analyzed
various
clinicopathological
parameters,
including
body
mass
index,
age
at
diagnosis,
menopausal
status,
pesticide
exposure,
tumor
characteristics
such
as
HER2
amplification,
Ki67
molecular
subtype,
histological
grade.
Results:
Two
primary
subsets
were
identified
being
associated
first
subset
(PC1)
characterized
by
amplification
metastatic
disease,
while
second
(PC2)
comprised
premenopausal
young
women
exposed
pesticides
had
triple-negative
tumors.
While
some
these
factors
are
well-documented
literature,
exposure
emerged
a
notable
regional
factor
contributing
poor
outcomes
patients.
Conclusion:
These
findings
underscored
significance
identifying
local
risk
when
assessing
cancer,
particularly
cases
which
is
treatment
approach.
Language: Английский
Insecticides and testicular health: mechanisms of injury and protective natural products
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
In
agriculture
and
public
health,
insecticides
are
vital
chemicals
that
help
manage
diseases
control
pests.
However,
their
extensive
use
has
raised
concerns
about
negative
consequences
on
both
humans
animals.
Pesticide
exposure
impacts
numerous
human
organs,
including
the
reproductive
system.
Infertility
is
caused
by
system
disorders,
which
why
they
have
received
a
lot
of
attention
in
recent
decades.
According
to
what
currently
known,
among
substances
may
lower
quality
semen
produced
exposed
workers.
The
mechanisms
this
action
still
unclear,
even
though
underlying
been
suggested.
With
an
emphasis
harmful
effects
male
processes,
review
provides
thorough
analysis
toxicity
profile
these
substances.
To
reduce
insecticides'
animal
health
direct
future
research
initiatives,
it
essential
comprehend
consequences.
Language: Английский
Mortality from breast cancer and use of pesticides in the western mesoregion of Santa Catarina – Brazil
Revista Brasileira de Ciências Ambientais,
Journal Year:
2024,
Volume and Issue:
59
Published: Jan. 1, 2024
Chronic
exposure
to
endocrine-disrupting
pesticides
may
be
related
breast
cancer
emergence
in
agricultural
regions.
This
study
aimed
investigate
whether
the
consumption
of
is
correlated
with
mortality
rates
female
population
western
Santa
Catarina.
A
retrospective
ecological
was
carried
out.
The
number
deaths
from
and
production
per
planted
area
mesoregion
were
obtained
public
databases.
average
standardized
coefficients
calculated
periods:
2005
2009,
2010
2014,
2015
2019.
Raw
data
on
pesticide
grouped
2000
2004,
considering
that
biological
effects
chronic
occur
late.
Thus,
previous
considered
this
study,
which
occurred
five,
ten,
15
years
before
death.
For
statistical
analysis,
thematic
cartography
Quantum
GIS
technique
used.
overlay
method
applied
perform
spatial
correlation.
Considering
exposure,
sum
municipalities
an
above-average
rate
93
118
Catarina,
have
history
(R2=0.69).
In
79%
cases,
at
a
frequency
above
whose
also
exceeded
regional
average.
proportional
correlation
between
use
found.
Language: Английский
Biomarkers of Pesticide Exposure in a Traditional Brazilian Amazon Community
International Journal of Environmental Research and Public Health,
Journal Year:
2024,
Volume and Issue:
21(11), P. 1396 - 1396
Published: Oct. 23, 2024
In
2008,
Brazil
became
the
country
with
highest
pesticide
use
in
world,
over
one
billion
liters
of
pesticides
applied
to
crops
2009.
The
impacts
these
products
on
public
health
are
wide-ranging.
Vast
territories
affected,
involving
different
population
groups,
such
as
workers
various
fields
activity,
that
consumes
contaminated
food,
and
people
living
around
factories,
traditional
communities.
This
study
aimed
assess
human
exposure
through
epidemiological
laboratory
data
residents
Santo
Antônio
quilombola
community
Concórdia
do
Pará,
Amazon
region,
Brazil.
Epidemiological
were
collected
using
a
semi-structured
questionnaire,
which
included
factors
sex,
age,
length
residence,
level
pesticides.
modified
Ellman
method
was
used
activity
cholinesterases,
flow
cytometry
performed
for
cytokine
analysis.
Analysis
blood
samples
showed
that,
most
cases,
there
no
significant
reduction
acetylcholinesterase
(AChE)
butyrylcholinesterase
(BChE)
compared
other
studies
scientific
literature.
Meanwhile,
an
increase
levels
IFN-γ
cytokines,
especially
IL-6,
all
groups.
findings
this
highlight
urgent
need
comprehensive
monitoring
program,
considering
some
conditions
than
can
alter
activities
biomarkers
study.
Language: Английский