Infectious Disorders - Drug Targets, Journal Year: 2024, Volume and Issue: 25(1)
Published: April 30, 2024
Language: Английский
Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(4)
Published: April 1, 2024
Abstract Natural Killer (NK) cells play a significant role in the early defense against virus infections and cancer. Recent studies have demonstrated involvement of NK both induction effector phases vaccine‐induced immunity various contexts. However, their shaping immune responses following SARS‐CoV‐2 vaccination remains poorly understood. To address this matter, we conducted comprehensive analysis cell phenotype function unexposed individuals who received BNT162b2 vaccine. We employed longitudinal study design utilized panel 53 15‐mer overlapping peptides covering receptor binding domain (RBD) Spike protein to assess at 0 20 days first vaccine, 30 240 booster. Additionally, evaluated levels total IgG anti‐Spike antibodies potential neutralizing ability. Our findings revealed an increased activity upon re‐exposure RBD when combined with IL12 IL18 several months after Concurrently, observed that frequencies NKG2A + declined over course follow‐up period, while NKG2C only CMV positive subjects. The finding functions are inducible 9 cytokines, sheds light on contributing protection pave way further field.
Language: Английский
Citations
6
Immunotherapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13
Published: Feb. 5, 2025
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells both play essential roles in controlling viral infections by eliminating virus-infected cells. Unlike CTLs, which require priming activation antigen-presenting cells, NK possess a remarkable capacity to mount rapid antiviral immune response immediately after infection. Additionally, they can bolster the adaptive system secreting cytokines directly interacting with other However, during chronic human immunodeficiency virus (HIV) infection, various including experience functional impairments. This has led exploration of cell-based immunotherapy as promising strategy reverse these dysfunctions contribute pursuit cure for HIV. Building on success cell therapies cancer treatment, approaches offer significant potential transforming HIV field. review provides comprehensive overview latest advances HIV, outlining progress made key challenges that must be overcome achieve people living
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8516 - 8516
Published: Aug. 5, 2024
Marburg virus (MARV), a filovirus, was first identified in 1967 Marburg, Germany, and Belgrade, former Yugoslavia. Since then, MARV has caused sporadic outbreaks of human disease with high case fatality rates parts Africa, the largest outbreak occurring 2004/05 Angola. From 2021 to 2023, occurred Guinea, Ghana, New Tanzania, emphasizing expansion its endemic area into new geographical regions. There are currently no approved vaccines or therapeutics targeting MARV, but several vaccine candidates have shown promise preclinical studies. We compared three platforms simultaneously by vaccinating hamsters either single dose an adenovirus-based (ChAdOx-1 MARV) vaccine, alphavirus replicon-based RNA (LION-MARV) recombinant vesicular stomatitis virus-based (VSV-MARV) all expressing glycoprotein as antigen. Lethal challenge hamster-adapted 4 weeks after vaccination resulted uniform protection VSV-MARV LION-MARV groups 83% ChAdOx-1 group. Assessment antigen-specific humoral response functionality revealed vaccine-platform-dependent differences, particularly Fc effector functions.
Language: Английский
Citations
1
Infectious Disorders - Drug Targets, Journal Year: 2024, Volume and Issue: 25(1)
Published: April 30, 2024
Language: Английский
Citations
0