Exploring the Frontier: The Human Microbiome’s Role in Rare Childhood Neurological Diseases and Epilepsy DOI Creative Commons
Newell Belnap, Keri Ramsey,

Sophia T. Carvalho

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1051 - 1051

Published: Oct. 23, 2024

Emerging research into the human microbiome, an intricate ecosystem of microorganisms residing in and on our bodies, reveals that it plays a pivotal role maintaining health, highlighting potential for microbiome-based interventions to prevent, diagnose, treat, manage myriad diseases. The objective this review is highlight importance microbiome studies enhancing understanding rare genetic epilepsy related neurological disorders. Studies suggest gut acting through gut-brain axis, impacts development severity epileptic conditions children. Disruptions microbial composition can affect neurotransmitter systems, inflammatory responses, immune regulation, which are all critical factors pathogenesis epilepsy. This growing body evidence points microbiome-targeted therapies, such as probiotics or dietary modifications, innovative approaches managing By harnessing power we stand develop more effective personalized treatment strategies children affected by disease other

Language: Английский

Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update DOI Open Access

Júlia Pauli De Cól,

Enzo Pereira de Lima,

Fernanda Moris Pompeu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694

Published: March 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Language: Английский

Citations

12
Microbial Symphony: Exploring the Role of the Gut in Osteoarthritis-Related Pain. A Narrative Review DOI Creative Commons
Alberto Corriero, Mariateresa Giglio,

Rossana Soloperto

et al.

Pain and Therapy, Journal Year: 2024, Volume and Issue: 13(3), P. 409 - 433

Published: April 27, 2024

One of the most common musculoskeletal disorders, osteoarthritis (OA), causes worldwide disability, morbidity, and poor quality life by degenerating articular cartilage, modifying subchondral bone, inflaming synovial membranes. OA pathogenesis pathways must be understood to generate new preventative disease-modifying therapies. In recent years, it has been acknowledged that gut microbiota (GM) can significantly contribute development OA. Dysbiosis GM disrupt "symphony" between host GM, leading a immunological response activates "gut–joint" axis, ultimately worsening This narrative review summarizes research supporting "gut–joint axis" hypothesis, focusing on interactions immune system in its two main components, innate adaptive immunity. Furthermore, pathophysiological sequence events link imbalance OA-related pain is broken down further investigated. We also suggest diet prebiotics, probiotics, nutraceuticals, exercise, fecal transplantation could improve management represent potential therapeutic tool light scarce panorama drugs (DMOADs). Future needed elucidate these complex interactions, prioritizing how particular change i.e., rise or drop specific bacterial strain, correlates with certain subset pinpoint associated signaling pathway leads

Language: Английский

Citations

7
Unlocking the therapeutic potential of gut microbiota for preventing and treating aging-related neurological disorders DOI
Geetika Garg,

Anchal Trisal,

Abhishek Kumar Singh

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions DOI
Naveen Jeyaraman,

Madhan Jeyaraman,

Priya Dhanpal

et al.

World Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 11, 2025

The gut microbiome, a complex ecosystem of microorganisms, has significant role in modulating pain, particularly within orthopaedic conditions. Its impact on immune and neurological functions is underscored by the gut-brain axis, which influences inflammation, pain perception, systemic responses. This integrative review examines current research how dysbiosis associated with various pathways, notably nociceptive neuroinflammatory mechanisms linked to central sensitization. We highlight advancements meta-omics technologies, such as metagenomics metaproteomics, deepen our understanding microbiome-host interactions their implications pain. Recent studies emphasize that gut-derived short-chain fatty acids microbial metabolites play roles neuroinflammation nociception, contributing management. Probiotics, prebiotics, synbiotics, faecal microbiome transplants are explored potential therapeutic strategies alleviate through modulation, offering an adjunct or alternative opioids. However, variability individual microbiomes poses challenges standardizing these treatments, necessitating further rigorous clinical trials. A multidisciplinary approach combining microbiology, immunology, neurology, orthopaedics essential develop innovative, personalized management rooted health, transform care.

Language: Английский

Citations

0
Deciphering the role of cell signaling pathways in gout pathogenesis and the therapeutic potential of phytoconstituents in their modulation DOI
Hrithik Dey, Syed Salman Ali, Vandana Arora Sethi

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

Citations

0
Gene regulatory networks analysis for the discovery of prognostic genes in gliomas DOI Creative Commons
Pedro Marçal Barcelos, Igor Salerno Filgueiras,

Adriel Leal Nóbile

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 23, 2025

Gliomas are the most common and aggressive primary tumors of central nervous system. Dysregulated transcription factors (TFs) genes have been implicated in glioma progression, yet these tumors' overall structure gene regulatory networks (GRNs) remains undefined. We analyzed transcriptional data from 989 gliomas The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) to address this. GRNs were reconstructed using RTN package which identifies regulons-sets regulated by a TF based on co-expression mutual information. Regulon activity was evaluated through Gene Set Enrichment Analysis. Elastic net regularization Cox regression identified 31 32 prognostic TCGA CGGA datasets, respectively, with 11 overlapping, many associated neural development synaptic processes. GAS2L3, HOXD13, OTP demonstrated strongest correlations survival outcomes among these. Single-cell RNA-seq analysis 201,986 cells revealed distinct expression patterns for subpopulations, particularly oligoprogenitor cells. This study uncovers key gliomas, offering new insights into tumor biology potential therapeutic targets.

Language: Английский

Citations

0
Supporting Neurologic Health with Mushroom Nutrition DOI Open Access
Victoria Bell,

Plamen Dimitrov,

Tito Fernandes

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1568 - 1568

Published: May 2, 2025

Due to the extensive types of etiologies and risks causing over 600 mental health issues, convene adequate recommendations in primary care is a difficult assignment. The starting point for preventive interventions on neurologic disorders involves scrutinizing risk factors while targeting multiple hazards order increase success an early precautionary mediation plan action. factor most neurodegenerative diseases increasing worldwide median age, although one seven youngsters also experience disability, namely depression, representing decline well-being conferring considerable global public challenge. brain operates optimally when supported by holistic approach engaging several aspects, diet becoming integral part strategies. Treatment presently dominated pharmacotherapy, but additional strategies are needed prevent treat disorders. Dietary modification can prove be cost-effective strategy prevention and, certain conditions, treatment neurological Molecules dietary ingredients, micronutrients, phytonutrients, additives may modulate depression associated biomarkers. Nutritional exposure during developmental stages maternal impact, lifestyles, modulation gut microbiota through as novel therapies various neuropsychiatric conditions gaining interest maintaining health. Bioactive substances present different mushroom species have been ascribed both direct indirect mechanisms influence neurobehavior, here we support recognition nutrition influential element management some concerns. Scientific evidence demonstrating unequivocal link between nutritional mushrooms cognitive only beginning emerge, medicine should considered care.

Language: Английский

Citations

0
Causal effect of air pollution on the risk of brain health and potential mediation by gut microbiota DOI Creative Commons
Xingwang Zhou,

Zhengshan Guo,

Yuanguo Ling

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117080 - 117080

Published: Sept. 26, 2024

Language: Английский

Citations

3
Macrophage-enriched novel functional long noncoding RNAs LRRC75A-AS1 and GAPLINC regulate polarization and innate immune responses DOI
Araceli Valverde, Raza Ali Naqvi, Afsar R. Naqvi

et al.

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(5), P. 771 - 792

Published: April 9, 2024

Language: Английский

Citations

2
Exploring the pathogenesis and treatment of PSD from the perspective of gut microbiota DOI Creative Commons

Mingqin Shi,

Zhenmin Li,

Zhengxiu Tang

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 215, P. 111022 - 111022

Published: June 25, 2024

Post-stroke depression (PSD) is a psychological disease that can occur following stroke and associated with serious consequences. Research on the pathogenesis treatment of PSD still in infancy stage. Patients often exhibit gastrointestinal symptoms; therefore role gut microbiota pathophysiology potential effects has become hot topic research. In this review, describe research therapy PSD. We also how influences neurotransmitters, endocrine system, energy metabolism, immune system. It was proposed involved through regulation neurotransmitter levels, vagal signaling, hypothalamic–pituitary–adrenal axis activation inhibition, hormone secretion release, addition to immunity inflammation.

Language: Английский

Citations

1