Research progress on the effect of pyroptosis on the occurrence, development, invasion and metastasis of colorectal cancer DOI Open Access

Xu Wang,

Qi-Hang Yin,

Lin-Lu Wan

et al.

World Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 16(8), P. 3410 - 3427

Published: Aug. 7, 2024

Pyroptosis is a type of programmed cell death mediated by gasdermines (GSDMs). The N-terminal domain GSDMs forms pores in the plasma membrane, causing membrane rupture and release contents, leading to an inflammatory response mediating pyrodeath. plays important role diseases malignant tumors. With further study pyroptosis, increasing number studies have shown that pyroptosis pathway can regulate tumor microenvironment antitumor immunity colorectal cancer closely related occurrence, development, treatment prognosis cancer. This review aimed explore molecular mechanism (CRC) provide ideas for clinical diagnosis CRC.

Language: Английский

Harnessing Pyroptosis for Cancer Immunotherapy DOI Creative Commons
Christopher M. Bourne, Cornelius Y. Taabazuing

Cells, Journal Year: 2024, Volume and Issue: 13(4), P. 346 - 346

Published: Feb. 16, 2024

Cancer immunotherapy is a novel pillar of cancer treatment that harnesses the immune system to fight tumors and generally results in robust antitumor immunity. Although has achieved remarkable clinical success for some patients, many patients do not respond, underscoring need develop new strategies promote Pyroptosis an immunostimulatory type regulated cell death activates innate system. A hallmark pyroptosis release intracellular contents such as cytokines, alarmins, chemokines can stimulate adaptive activation. Recent studies suggest promotes Here, we review mechanisms by which be induced highlight induce cells defense. We discuss how modulates tumor microenvironment immunity also research areas focus on continued development anticancer treatment. Pyroptosis-based therapies offer promising avenue treating immunologically 'cold' tumors.

Language: Английский

Citations

8
Oridonin exerts anticonvulsant profile and neuroprotective activity in epileptic mice by inhibiting NLRP3-mediated pyroptosis DOI Creative Commons
Ting Zhao,

Xuefei Zhang,

Xiaoxiao Cui

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 134, P. 112247 - 112247

Published: May 16, 2024

Epilepsy is a chronic disabling disease poorly controlled by available antiseizure medications. Oridonin, bioactive alkaloid with anti-inflammatory properties and neuroprotective effects, can inhibit the increased excitability of neurons caused glutamate accumulation at cellular level. However, whether oridonin affects neuronal it has antiepileptic potential not been reported in animal models or clinical studies. Pentylenetetrazol was injected into mice to create model epilepsy. Seizure severity assessed using Racine scale, duration latency seizures were observed. Abnormal discharge detected electroencephalography, calcium imaging. Damage hippocampal evaluated Hematoxylin-Eosin Nissl staining. The expression NOD-like receptor thermal protein domain associated 3 (NLRP3) inflammasome other pyroptosis-related proteins determined western blotting immunofluorescence. A pyroptosis established supernatant BV2 cells treated lipopolysaccharide adenosine triphosphate stimulate neurons. Oridonin (1 5 mg/kg) reduced damage, seizures, shortened fully kindled epilepsy mice. decreased abnormal during epileptic episodes suppressed excitability. In vitro experiments showed that alleviated HT22 exerts effects inhibiting through NLRP3/caspase-1 pathway It also reduces vitro, suggesting its as therapy for

Language: Английский

Citations

6
Harnessing Pyroptosis for Lung Cancer Therapy: The Impact of NLRP3 Inflammasome Activation DOI
Rajiv Dahiya, Vijaykumar Sutariya, Sheeba Varghese Gupta

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155444 - 155444

Published: Aug. 1, 2024

Language: Английский

Citations

4
METTL3‐mediated m6A modification enhances lncRNA H19 stability to promote endothelial cell inflammation and pyroptosis to aggravate atherosclerosis DOI Creative Commons
Feng Tang,

Long‐hai Tian,

Xiaohan Zhu

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(20)

Published: Oct. 21, 2024

Abstract This study explored the impact of N 6 ‐methyladenosine (m6A) modification on regulation long noncoding RNA (lncRNA) and atherosclerosis progression. An cell model was established by treating human aortic endothelial cells (HAECs) with oxidized low‐density lipoprotein. Additionally, an atherosclerotic animal developed using ApoE −/− C57BL/6 male mice fed a high‐fat diet. Both models were employed to assess expression changes proteins associated m6A modification. First, effect writer protein methyltransferase‐like 3 (METTL3) knockdown in level pyroptosis HAECs investigated, bioinformatic analysis confirmed that lncRNA H19 (H19) potential target RNA‐binding immunoprecipitation assays subsequently performed explore interaction between METTL3, as well reader recombinant insulin‐like growth factor 2 mRNA‐binding (IGF2BP2). Finally, levels evaluated. In aortas mice, overall significantly elevated compared controls ( p < .05), METTL3 METTL14 mRNA notably increased .05). Similarly, ox‐LDL‐treated showed significant rise levels, along led decreased pyroptosis, evidenced reduced lactate dehydrogenase release lower IL‐1β, IL‐18, IL‐6 Overexpression reversed these effects, indicating METTL3's role promoting stabilizing through primary molecule METTL3‐mediated pathogenesis atherosclerosis. regulated expression, thereby aggravating activating pyroptosis.

Language: Английский

Citations

4
Aquaporin-5 facilitates liver regeneration following hepatectomy via ROS/GSDMD pathway DOI
Bin Li, Guohu Di, Huanhuan Ge

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: 127, P. 111602 - 111602

Published: Jan. 14, 2025

Language: Английский

Citations

0
Nanomaterials as Modulators of Non-apoptotic Regulated Cell Death Modes: Novel Options in Cancer Treatment DOI
Anton Tkachenko

Interdisciplinary cancer research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Novel pyroptosis-immune-related lncRNA signature exhibits a distinct immune cell infiltration landscape in breast cancer DOI Creative Commons

Dedi Kong,

Hongju Cheng, Meihong Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 21, 2025

Introduction This study investigated pyroptosis- and immunity-related long non-coding RNAs (lncRNAs) to identify promising therapeutic targets for breast cancer (BC), constructed lncRNA signatures determine the prognosis immunotherapy responses of BC patients. Methods Pearson’s correlation coefficient was used immune-related differentially expressed lncRNAs (DE-pyrolncRNAs DE-ImmlncRNAs, respectively). The Cancer Genome Atlas dataset allocated training testing subsets. Prognostic were derived based on subset using univariate Cox regression analysis Least Absolute Shrinkage Selection Operator methods. Stepwise refine these select optimal signature. median risk score applied as a threshold divide patients into high-risk (HR) low-risk (LR) groups. Wilcoxon test reveal differences in immune scores, cell types, functions, checkpoint genes between Single-cell sequencing data from GSE176078 validate infiltration landscape identified signatures. Results We six-lncRNA pyroptosis-immune signature comprising MAPT.AS1, CTA.384, D8.34, RP11.561, I11.3, HID1.AS1, AC097713.3, USP2.AS1. Patients HR group demonstrated inferior prognoses training, testing, full datasets (P=3.622e-07, P=3.736e-03, P=1.151e-08, Immune scores significantly enhanced LR group, whereas tumor purity elevated group. Fifty-eight showed significant groups (P&lt;0.05). function (APC coinhibition, CCR, checkpoints) more impaired Expression levels 38 genes, including KIR2DS4, KIR3DL2, CD40LG, KIR3DL1, PDCD1, higher Conversely, TDO2, PVR, CD276 sparse T cell, B myeloid, plasmablast clusters displayed clustering cells, myeloids, plasmablasts. Conclusion effectively predicted highlighted distinct patterns. holds promise evaluating guiding target identification BC.

Language: Английский

Citations

0
From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases — Opportunity or Challenge? DOI Creative Commons
Jintao Fang,

Weihan Zhu,

Dian Yu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 3349 - 3360

Published: March 1, 2025

Pyroptosis is a unique form of programmed cell death characterized by intense inflammation. It involves the activation Gasdermin proteins, which membrane pores, leading to rapid rupture and release inflammatory molecules. Unlike other types death, pyroptosis has distinct mechanisms plays complex role in chronic intestinal diseases, including bowel disease, fibrosis, infectious enteritis, colorectal cancer. This review comprehensively examines how influences disease development progression while exploring therapeutic potential targeting pyroptosis-related pathways. Moreover, interplay between gut microbiota summarized, highlighting its critical pathogenesis disorders. A deeper understanding these diseases may provide valuable insights for future research contribute innovative strategies gastroenterology.

Language: Английский

Citations

0
The role and intrinsic connection of cellular senescence and cell death in inflammatory bowel disease DOI Creative Commons

Lichao Yang,

Lianwen Yuan

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 24, 2025

Cellular senescence in the intestine can induce cell death, which extends beyond mere clearance of senescent cells. This phenomenon is prevalent inflammatory and immune-related diseases, particularly bowel disease (IBD). IBD characterized by recurrent chronic intestinal inflammation, with occurrence development being influenced multiple factors, including genetics, environment, lifestyle, immunity, gut microbiota. Chronic inflammation drives aging immune system, reducing its efficiency impairing The disruption death regulation interplay between cellular contribute to progression IBD, inflammaging immunosenescence playing key role this process. However, mechanisms underlying context remain unclear. Therefore, paper comprehensively reviews impact on emphasizing exploration their potential interrelationships.

Language: Английский

Citations

0
Targeting regulated cell death (RCD) in hematological malignancies: Recent advances and therapeutic potential DOI Open Access

Yu Zhang,

Xiangxiang Zhou

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116667 - 116667

Published: May 3, 2024

Regulated cell death (RCD) is a form of that can be regulated by numerous biomacromolecules. Accumulating evidence suggests dysregulated expression and altered localization related proteins in RCD promote the development cancer. Targeting subroutines with pharmacological small-molecule compounds becoming promising therapeutic avenue for anti-tumor treatment, especially hematological malignancies. Herein, we summarize aberrant mechanisms apoptosis, necroptosis, pyroptosis, PANoptosis, ferroptosis In particular, focus on relationship between tumorigenesis, immunotherapy, drug resistance Furthermore, discuss emerging strategies targeting different subroutines. This review aims to significance potential malignancies, along utilization pertinent strategies.

Language: Английский

Citations

3