Combined single cell and spatial transcriptome analysis reveals cellular heterogeneity of hedgehog pathway in gastric cancer DOI

Guoliang Zhang,

Guojun Xia,

Chunxu Zhang

et al.

Genes and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Language: Английский

lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer DOI Creative Commons
Asif Ahmad Bhat, Muhammad Afzal, Ehssan Moglad

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Language: Английский

Citations

9
Application of immune checkpoint inhibitors for resectable gastric/gastroesophageal cancer DOI Creative Commons

Feizhi Lin,

Yongming Chen, Bowen Huang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 9, 2024

Gastric/gastroesophageal junction (G/GEJ) cancer represents a significant global health challenge. Radical surgery remains the cornerstone of treatment for resectable G/GEJ cancer. Supported by robust evidence from multiple clinical studies, therapeutic approaches, including adjuvant chemotherapy or chemoradiation, and perioperative chemotherapy, are generally recommended to reduce risk recurrence enhance long-term survival outcomes post-surgery. In recent years, immune checkpoint inhibitors (ICIs) have altered landscape systemic advanced metastatic cancer, becoming standard first-line therapy specific patients. Consequently, exploring efficacy ICIs in neoadjuvant setting is worthwhile. This review summarizes current advances application

Language: Английский

Citations

4
Efficacy and safety of nivolumab plus ipilimumab in gastrointestinal cancers: a systematic review and meta-analysis DOI Creative Commons
Bowen Dai,

Jiaping Jiang,

Xiaoyu Yu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 7, 2025

Gastrointestinal (GI) cancers represent a significant global health burden, and the need for more effective treatment options is exceptionally pressing. The present meta-analysis aimed to explore efficacy safety of combination nivolumab ipilimumab in treating GI cancers. A systematic search four databases (PubMed, Embase, Web Science, Cochrane Library) was conducted articles on with combined ipilimumab, published from 2014 up 30 August 2024. inclusion criteria were designed according principles Participants, Intervention, Control, Outcomes, Study (PICOS). control group chemotherapy or monotherapy other drugs. We extracted data 10 randomized controlled trials utilized random effects model assess objective response rate (ORR), median progression-free survival (mPFS), overall (mOS), duration (mDOR), treatment-related adverse events (TRAEs). analysis using Review Manager version 5.4 Stata 12.0. Overall, demonstrated superior outcomes, including higher ORR (OR = 1.69, P 0.01), prolonged mOS (MD 1.74, 0.04) extended mDOR 5.64, < 0.00001) compared group. Subgroup that 1.75, 0.02) 5.02, 0.003) significantly improved patients esophageal cancer. Notably, biliary cancer lower 0.11, 0.04). Additionally, NIVO1 + IPI3group 2.82, 0.01) NIVO3 IPI1 1.62, 0.01). Regarding safety, there no statistically difference between regimen terms any grade 0.72, 0.26) 3-4 TRAEs 1.36, 0.14). Nivolumab (especially cancer) without causing reactions. However, its still needs be further proven. https://www.crd.york.ac.uk/prospero/, identifier CRD42024590994.

Language: Английский

Citations

0
Actinidia eriantha polysaccharide prevents gastric cancer invasion and metastasis via inhibition of PD-1/PD-L1 regulation of macrophage polarization DOI Creative Commons
Jinxia Li, Kun Gao, Ying Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140763 - 140763

Published: Feb. 6, 2025

Language: Английский

Citations

0
Deciphering the Role of DNA Methylation-Driven Genes in Rectal Cancer: Insights into Prognostic Modeling and Mechanistic Pathways DOI Creative Commons
Weipeng Liu,

Lugao Tian,

Weiwei Wei

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Background DNA methylation alterations play a crucial role in rectal cancer development. This study identifies and characterizes methylation-driven genes the TCGA-READ cohort, exploring their association with development underlying mechanism. Methods were identified using MethylMix package subjected to gene ontology (GO) enrichment analysis via cluster profiler package. Prognostic model involved Lasso regression ten-fold cross-validation, followed by performance evaluation Kaplan-Meier survival curves, time-dependent ROC calibration decision curve analysis. Cancer-promoting mechanism high risk score group was clarified through set (GSEA) multi-algorithm-based immune infiltration analyses. Results GO highlighted significant functional terms based on 490 genes, implicating Wnt signaling cell fate commitment The developed prognostic model, consisting of CCNI2, LINC00899, ST6GALNAC1, exhibited predictive accuracy. Differential expression 89 underexpressed high-risk group, SULF1 as hub gene. negative regulation process malignant tumor-associated pathways is suppressed, decreased abundance cytotoxic cells, such NK may represent potential for poor prognosis observed group. Conclusions Our findings elucidate landscape cancer. These insights contribute deeper understanding progression provide targets therapeutic intervention.

Language: Английский

Citations

0
Comprehensive analysis and experimental validation of disulfidptosis-associated prognostic signature and immune microenvironment characterization of gastric cancer DOI Creative Commons

Huangjie Zhang,

Jinguo Hu,

Yuanqiang Li

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(4)

Published: Feb. 25, 2025

Gastric cancer (GC) is one of the most common causes cancer-related death worldwide. As a novel form programmed cell death, disulfidptosis characterized by excessive cysteine accumulation, disulfide stress and actin destruction. There evidence that targeting promising anticancer strategy. Further improvement GC risk stratification based on has positive clinical significance. We analyzed expression levels disulfidptosis-associated genes (DPAGs) in normal tissues molecular subtypes patients. Based characteristics DPAG subtypes, differentially expressed prognosis-related were selected LASSO-univariate Cox analysis multivariate to establish prognostic model. Using single-cell sequencing reveals subpopulation for GC. The function target was verified vitro experimental means, including siRNA, qRT-PCR, Western blot, CCK-8, Transwell assay. score be an independent factor significantly associated with poor prognosis gastric cancer. Subsequent studies subgroup immunoinfiltration characteristics, drug sensitivity analysis, immunotherapy response somatic mutation comprehensively confirmed potential guiding significance individualized treatment Single-cell revealed DPAG-related signatures across subpopulations. In experiments showed APC11, as DPAGs, highly cancer, knockdown APC11 could inhibit proliferation migration cells, demonstrating reliability bioinformatics results. results this study provide new perspective exploring role occurrence development

Language: Английский

Citations

0
Immunotherapy-induced psoriasis successfully treated with Guselkumab in a patient with metastatic gastric cancer DOI Creative Commons
Denis Miyashiro,

Thiago William Carnier Jorge,

André Luís da Silva Hirayama

et al.

Anais Brasileiros de Dermatologia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Molecular characteristics and cancer immunity of LRP1B and its relationship with the Hedgehog signaling pathway in colorectal cancer DOI Creative Commons
Yuan Liu, Yang Zhong, Yaodong Sang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Colorectal cancer (CRC) is a malignant tumor of the digestive tract that significantly impacts human health. LDL receptor-related protein 1B (LRP1B) may play crucial role in tumorigenesis and disease progression. We performed comparative analysis differential gene expression, mutation patterns, drug sensitivity, cellular phenotypes across different subgroups with varying LRP1B expression levels. Cellular molecular experiments were conducted to validate our findings. Our implicated as suppressor gene. Experimental results confirmed was reduced CRC its knockdown associated poor prognosis. Molecular mechanism studies revealed negatively regulated Hedgehog (Hh) signaling pathway, influencing cell cycle apoptosis processes. Single-cell showed significant differences infiltration T cells, B epithelial myeloid cells between high low groups. Immune sensitivity analyses demonstrated plays immunotherapy targeted therapy, suggesting restoring function could be promising treatment strategy for CRC. indicate factor CRC, playing mutation, immune infiltration. Knockdown activates Hh pathway leading inhibition several biological behaviors.

Language: Английский

Citations

0
Gastrointestinal cancer: Current status of preclinical research DOI
Nariman Shahid, Sana Hanif,

Muhammad Ali Syed

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 317 - 348

Published: Jan. 1, 2025

Language: Английский

Citations

0
Circular RNA Circ_0000119 promotes gastric cancer progression via circ_0000119/miR-502-5p/MTBP axis DOI
Mengyan Xie, Yunru Gu, Tingting Xu

et al.

Gene, Journal Year: 2024, Volume and Issue: 908, P. 148296 - 148296

Published: Feb. 18, 2024

Language: Английский

Citations

3