Comparison of Efficacy of Oral Tofacitinib (JAK Inhibitor) Combined with Narrow Band UVB Vs Alone Oral Tofacitinib in Patient with Vitiligo at Tertiary Care Hospital, Karachi DOI Creative Commons

Soonha Iqra,

Rabia Ghafoor,

Muhammad Tarish Abro

et al.

Indus journal of bioscience research., Journal Year: 2024, Volume and Issue: 2(2), P. 1493 - 1497

Published: Dec. 31, 2024

Objective: compare the oral Tofacitinib added to NB-UVB phototherapy versus monotherapy in patients with vitiligo, at a tertiary care teaching hospital Karachi. Methods: After ethical approval from institutional review board, this open-label, non-randomized study is conducted Department of Dermatology, JPMC, Karachi April 2024 Sep 2024. Through non-probability consecutive sampling, 40 aged 18 above, both genders, diagnosed vitiligo stable lesions for half year were included present study. The divided into groups: Group B that received only 5 mg twice day (n=20) and A treated combination three time weekly (n=20). Results: At 12 weeks, VASI score showed significant improvement + group (36.8 ± 8.3) compared alone (54.15 9.5, p < 0.0001). percentage was also significantly higher therapy 57.4 9.7% 36.7 9.9% (p Furthermore, efficacy outcome, defined as ≥51% re-pigmentation, achieved 15 (75%) 1 patient (5%) group, highly p-value <0.0001. Conclusion: Oral tofacitinib complemented more effective than re-pigmentation patients.

Language: Английский

The Role of Platelet-Rich Plasma in Biomedicine: A Comprehensive Overview DOI Creative Commons
Zhixin Zhang, Peng Liu,

Xinmiao Xue

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(2), P. 111705 - 111705

Published: Jan. 5, 2025

Biomedicine has seen significant advancements in the 21st century, with platelet-rich plasma (PRP) playing a crucial role clinical practice. This blood derivative, enriched platelet components, shown great potential for promoting tissue repair and regeneration. Its wide range of applications presence anti-inflammatory growth-promoting factors make it valuable tool field biomedicine. The exploration PRP settings been gaining momentum. Despite its cost-effectiveness, safety, therapeutic efficacy, widespread adoption hindered by absence consistent preparation standards standardized treatment protocols. article provides comprehensive analysis uses, physiological roles, molecular mechanisms, techniques aim is to offer thorough understanding benefits medical

Language: Английский

Citations

2
Sensitivity and Specificity Analysis of Different Lesion Areas of Vitiligo by Reflectance Confocal Microscopy DOI Creative Commons

Jiyuan Wu,

Miaomiao Sun,

Zijia Wei

et al.

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(2)

Published: Feb. 1, 2025

ABSTRACT Background Clinical diagnosis and staging of vitiligo often rely on the patient's subjective recollection, physician's experience, or clinical evaluation methods. An objective, quantitative diagnostic approach is lacking. Aims This study was performed to compare sensitivity specificity different lesion areas full scanning using reflectance confocal microscopy (RCM) for vitiligo. Methods RCM data patients diagnosed with were collected. gathered from three sites a lesion: center lesion, margin perilesional normal skin. Scoring conducted each method, categorizing results as either progressive stable stage Results The significantly lower in skin than at multiple ( p < 0.001). higher 0.05 all). Conclusions showed that rate missed lowest comparable sites. misdiagnosis skin, differing other Overall, yielded most accurate results, offering flexibility selection according compliance.

Language: Английский

Citations

0
Clinical and dermoscopic assessment of the efficacy of topical trichloroacetic acid 70% versus methoxsalen 0.2% paint in stable acral vitiligo DOI Creative Commons

Ahmed R. Elshahed,

Amr Mohammad Ammar,

Abdallah Mamdouh lotfy Ali

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 8, 2025

Abstract Loss and absence of melanocytes due to a number factors is responsible for vitiligo; known be the commonest disorder pigmentation. The aim study was assess clinically dermoscopically efficacy topical trichloroacetic acid 70% versus methoxsalen 0.2% paint in stable acral vitiligo. patients were randomly divided into 2 groups. Group ( n = 35) received every other day 4 months duration with dermoscopic follow up while group b TCA application at clinic two weeks up. majority subjects both groups experienced either no or mild improvement. In group, mean improvement 4.0 ± 11.6% range 0–60% 0.57 3.3% 0–20% p 0.051). reported poor satisfaction. Both modalities did not demonstrate significant clinical nor response. had lower effective rate than studies probably resistance vitiliginous lesions treatment comparison sites body. Further larger multi centre different concentration combination are required detect promising treatments vitligo.

Language: Английский

Citations

0
Dermatological Indications: Vitiligo DOI
Kağan Cingöz

Published: Jan. 1, 2025

Citations

0
Recent trends in the treatment of vitiligo using novel drug delivery system DOI

Nandita Sahu,

Parag Jain,

Deepika Sahu

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125106 - 125106

Published: Dec. 1, 2024

Language: Английский

Citations

2
Manejo do vitiligo baseado em evidências: resumo de uma revisão sistemática DOI Open Access

Barbara Marin Augusto,

Caroline Santos,

Mariana da Silveira Castro

et al.

Journal Archives of Health, Journal Year: 2024, Volume and Issue: 5(3), P. e2116 - e2116

Published: Aug. 1, 2024

Introdução: O vitiligo é uma doença de pele despigmentante crônica, não sendo totalmente compreendida em seu ponto vista etiopatogênico. Além disso, possui possibilidade tratamento ainda limitada e pouco específica. Devido ao fato ser estigmatizante com tratamentos específicos, o presente artigo tem como objetivo revisão sistemática baseada evidências sobre manejo atual do vitiligo, visando avaliar as possibilidades tratamento. Materiais, sujeitos métodos: Para a elaboração deste foram utilizados artigos científicos publicados referenciados na Medline/PubMED entre 2021 2023. Resultados discussão: A diversos tipos formas apresentação clínica, pautado acordo extensão atividade da doença. As opções incluem uso terapia ultravioleta B banda estreita (NB-UVB), imunossupressores corticoides, metotrexato, azatioprina Apremilast, inibidores calcineurina. Considerações finais: No apesar longo, bons resultados têm sido vistos realizando terapias duplas, associando fototerapia imunossupressores, corticoides ou metotrexato e/ou

Citations

1
Palmitoyl copper peptide and acetyl tyrosine complex enhances melanin production in both A375 and B16 cell lines DOI
Minhua Hong, Y. S. Gui,

Jiayao Xu

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 742, P. 151060 - 151060

Published: Nov. 28, 2024

Language: Английский

Citations

1
Impactos biopsicossociais enfrentados por pacientes com vitiligo: Uma revisão sistemática DOI Creative Commons

Ana Clara Junqueira Tedeschi,

Júlia Sammour,

Bianca De Castro

et al.

LUMEN ET VIRTUS, Journal Year: 2024, Volume and Issue: 15(39), P. 1667 - 1677

Published: Aug. 6, 2024

Objective: The aim of this review was to report current knowledge about the main signs and symptoms that affect quality life individuals with vitiligo. Methodology: searches were carried out through in PubMed Central (PMC) databases. Three descriptors used combination Boolean term "AND": vitiligo; life; depression; psychosocial impact; Medical Psychology. From search, 275 articles found, which subsequently submitted selection criteria. Of which, after applying inclusion exclusion criteria, 36 selected from database, a total 19 studies compose collection. Discussion: Thus, denote skin, being largest organ body, is crucial for personal image diseases alter its pigmentation, such as vitiligo, reduce life, especially young people. biological embryonic point view, skin brain have an intimate relationship, suggests changes it can be associated mental health problems, exacerbating or triggering dermatological conditions, culminate nervousness, decreased self-confidence, anxiety even depression. Results: It known there may biomarker activity severity vitiligo where related prevalence psychiatric creating distortions. In summary, multifactorial autoimmune disease, would generate great impact on lives patients, influencing individual self-image way world will perceive it, thus resulting worsening life.

Language: Английский

Citations

0
Comparison of Efficacy of Oral Tofacitinib (JAK Inhibitor) Combined with Narrow Band UVB Vs Alone Oral Tofacitinib in Patient with Vitiligo at Tertiary Care Hospital, Karachi DOI Creative Commons

Soonha Iqra,

Rabia Ghafoor,

Muhammad Tarish Abro

et al.

Indus journal of bioscience research., Journal Year: 2024, Volume and Issue: 2(2), P. 1493 - 1497

Published: Dec. 31, 2024

Objective: compare the oral Tofacitinib added to NB-UVB phototherapy versus monotherapy in patients with vitiligo, at a tertiary care teaching hospital Karachi. Methods: After ethical approval from institutional review board, this open-label, non-randomized study is conducted Department of Dermatology, JPMC, Karachi April 2024 Sep 2024. Through non-probability consecutive sampling, 40 aged 18 above, both genders, diagnosed vitiligo stable lesions for half year were included present study. The divided into groups: Group B that received only 5 mg twice day (n=20) and A treated combination three time weekly (n=20). Results: At 12 weeks, VASI score showed significant improvement + group (36.8 ± 8.3) compared alone (54.15 9.5, p < 0.0001). percentage was also significantly higher therapy 57.4 9.7% 36.7 9.9% (p Furthermore, efficacy outcome, defined as ≥51% re-pigmentation, achieved 15 (75%) 1 patient (5%) group, highly p-value <0.0001. Conclusion: Oral tofacitinib complemented more effective than re-pigmentation patients.

Language: Английский

Citations

0