Long COVID as a Disease of Accelerated Biological Aging: An Opportunity to Translate Geroscience Interventions

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102400 - 102400

Published: June 28, 2024

Language: Английский

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Acquired hemophilia A as a disease of the elderly: A comprehensive review of epidemiology, pathogenesis, and novel therapy

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder characterized by the development of neutralizing autoantibodies (inhibitors) against coagulation factor VIII (FVIII). This review provides an in-depth exploration AHA, covering its epidemiology, pathogenesis, clinical presentation, diagnosis, complications, and treatment strategies, focusing on recent advancements. AHA can manifest in both men women with no prior history. The annual incidence estimated to be approximately 1 case per million individuals general population. increases significantly age: among aged 60 years or older 3 4 cases year. Typically, patients present acquired that isolated, prolonged activated partial thromboplastin time stemming from FVIII deficiency. Diagnosis relies detection antibodies using Nijmegen-modified Bethesda assay. Hemostatic control strategies involve bypassing agents like recombinant VII, prothrombin complex concentrate, porcine for patients. Emicizumab, novel agent, exhibits several potential advantages. In realm immunosuppressive inhibitor eradication, CyDRi regimen emerged as remarkable advancement, enhancing outlook management even elderly frail

Language: Английский

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Anthraquinones and Aloe Vera Extracts as Potential Modulators of Inflammaging Mechanisms: A Translational Approach from Autoimmune to Onco-Hematological Diseases

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1251 - 1251

Published: March 11, 2025

Inflammaging is a chronic, low-grade inflammatory state that contributes to age-related diseases, including cardiovascular disorders, osteoporosis, neurodegeneration, and cancer. This process involves immunosenescence, oxidative stress, immune aging, all of which contribute the breakdown tolerance onset autoimmune disorders. Aloe vera (AV) has recently gained attention for its immunomodulatory, anti-inflammatory, antioxidant properties. review explores effects AV extracts anthraquinones (e.g., aloe–emodin, emodin, aloin) on key inflammaging-driven mechanisms in autoimmunity. Our analysis highlights AV’s ability regulate hormone balance, autoantibody production, cytokine/chemokine signaling (such as interleukin-1β, tumor necrosis factor-α, interferon-γ). It modulates pathways, mitogen-activated protein kinases (MAPKs) phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), thereby inhibiting nuclear factor kappa-light-chain-enhancer activated B-cell (NF-κB) activation. Additionally, enhances defenses restores balance by reducing Th1/Th17 subsets while promoting Th2-mediated regulation. Notably, also inflammasome-mediated counteracts driven autophagy-related processes. These position potential integrative approach mitigating Furthermore, inflammaging increasingly recognized onco-hematological AV-based strategies may offer novel therapeutic avenues. Future studies should focus clinical validation, optimizing formulations, expanding applications broader immune-mediated

Language: Английский

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Explainable machine learning model and nomogram for predicting the efficacy of Traditional Chinese Medicine in treating Long COVID: a retrospective study

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 13, 2025

Introduction Long COVID significantly affects patients' quality of life, yet no standardized treatment has been established. Traditional Chinese Medicine (TCM) presents a promising potential approach with targeted therapeutic strategies. This study aims to develop an explainable machine learning (ML) model and nomogram identify patients who may benefit from TCM, enhancing clinical decision-making. Methods We analyzed data 1,331 treated TCM between December 2022 February 2024 at three hospitals in Zhejiang, China. Effectiveness was defined as improvement two or more symptoms minimum 2-point increase the Syndrome Score (TCMSS). Data included 11 patient disease characteristics, 18 syndrome scores, 12 auxiliary examination indicators. The least absolute shrinkage selection operator (LASSO) method identified features linked efficacy. 1,204 served training set, while 127 formed testing set. Results employed five ML algorithms: Support Vector Machine (SVM), Random Forest (RF), K-Nearest Neighbors (KNN), Extreme Gradient Boosting (XGBoost), Neural Network (NN). XGBoost achieved Area Under Curve (AUC) 0.9957 F1 score 0.9852 demonstrating superior performance set AUC 0.9059 0.9027. Key through SHapley Additive exPlanations (SHAP) chest tightness, aversion cold, age, TCMSS, Short Form (36) Health Survey (SF-36), C-reactive protein (CRP), lymphocyte ratio. logistic regression-based demonstrated 0.9479 0.9384 Conclusion utilized multicenter multiple algorithms create for predicting efficacy treatment. Furthermore, developed assist improve decision-making efficiency applications management.

Language: Английский

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Neuroimmune crosstalk in chronic neuroinflammation: microglial interactions and immune modulation

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 7, 2025

Neuroinflammation is a fundamental feature of many chronic neurodegenerative diseases, where it contributes to disease onset, progression, and severity. This persistent inflammatory state arises from the activation innate adaptive immune responses within central nervous system (CNS), orchestrated by complex interplay resident cells, infiltrating peripheral an array molecular mediators such as cytokines, chemokines, extracellular vesicles. Among CNS-resident microglia play role, exhibiting dynamic spectrum phenotypes ranging neuroprotective neurotoxic. In sustained microglial often leads amplification cascades, reinforcing pathogenic cycle immune-mediated damage. Intercellular communication inflamed CNS persistence progression neuroinflammation. Microglia engage in extensive crosstalk with astrocytes, neurons, oligodendrocytes, shaping both local systemic responses. These interactions influence key processes synaptic pruning, phagocytosis, blood-brain barrier integrity, cytokine-mediated signaling. Understanding mechanisms cell-cell signaling this context critical for identifying therapeutic strategies modulate response restore homeostasis. review explores players neuroinflammation, focus on role microglia, pathways underlying intercellular communication, potential approaches mitigate neuroinflammatory damage diseases.

Language: Английский

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Role of IL-16 in age-related skeletal muscle atrophy: an integrated study

BMC Musculoskeletal Disorders, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 17, 2025

In this study, we aim to explore the roles of IL-16 in sarcopenia based on older orthopedic patients and animal research. This clinical research study was an observational investigation included all with trauma admitted our department between January 2021 2022. Patients were identified if they have both low hand grip strength (HGS) appendicular skeletal muscle mass (ASM). Propensity score matching (PSM) performed reduce bias caused by co-factors levels normal compared. research, mice treated identify effects function mass. Then models established anti-IL-16 potential therapeutical effect targeting IL-16. 421 individuals 77 as sarcopenia. matched populations, serum HGS, ASM, significantly higher than (all p < 0.001). The showed impaired physical performance loss Using antibodies may rescue traits botulinum toxin type A. Individuals high a risk impairs leads atrophy mice, these could be reduced

Language: Английский

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The role of age-associated B cells in systemic lupus erythematosus

Journal of Autoimmunity, Journal Year: 2025, Volume and Issue: 154, P. 103433 - 103433

Published: May 6, 2025

Language: Английский

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Long COVID Syndrome: A Narrative Review on Burden of Age and Vaccination

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4756 - 4756

Published: Aug. 13, 2024

Background/Objective: The COVID-19 pandemic has led to the emergence of post-acute syndrome, also known as long COVID, which presents a significant challenge due its varied symptoms and unpredictable course, particularly in older adults. Similar infections, factors such age, pre-existing health conditions, vaccination status may influence occurrence severity COVID. objective is analyze role aging context COVID investigate prevalence rates efficacy improve prevention strategies treatment this age group. Methods: Four researchers independently conducted literature search PubMed database trace studies published between July 2020 2024. Results: Aging influences both likelihood developing recovery process, age-related physiological changes, immune system alterations, presence comorbidities. Vaccination plays key reducing risk by attenuating inflammatory responses associated with symptoms. Conclusions: Despite protection vaccines offer against severe infection, hospitalization, post-infection sequelae, vaccine hesitancy remains major obstacle, worsening impact Promising treatments for condition include antivirals although further research needed.

Language: Английский

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Clinical characteristics, anti-SARS-CoV-2 IgG titers, and inflammatory markers in individuals with post-COVID-19 condition in Kenya: a cross-sectional study

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17723 - e17723

Published: July 22, 2024

Background Post-coronavirus disease 2019 (post-COVID-19) is associated with considerable morbidity and reduced quality of life. However, studies characterizing the post-COVID-19 condition in Kenya are limited. This study aimed to determine prevalence clinical characteristics, anti-SARS-CoV-2 IgG titers, concentrations inflammatory markers individuals Kenya. Methods descriptive cross-sectional was conducted at Kenyatta University Health Unit, Demographic data were collected using a questionnaire. The serum levels antibodies, interleukin 6 (IL-6), C-reactive protein (CRP) quantified by enzyme-linked immunosorbent assays. Independent samples t-test used compare IgG, IL-6, CRP between participants without symptoms. case definition for persistence acute COVID-19 symptoms or emergence new 3 months after diagnosis, lasting ≥2 months, absence any other etiological basis explain Results A total 189 volunteers recruited this (median age: 21 years, range: 18–71 years; male, 49.2%). Forty reported having had least one positive diagnosis past, which 12 (30%) complained Significant differences number duration observed ( t -statistic = 2.87, p 0.01; 2.39, 0.02, respectively). no significant two groups P 0.08, 0.9, 0.28, Conclusion These findings suggest that health concern even relatively young population globally. requires more attention well-designed better define it identify chemistry can be its diagnosis.

Language: Английский

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Recurrent pericarditis in older adults: Clinical and laboratory features and outcome

Journal of the American Geriatrics Society, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract Background Current guidelines for the diagnosis and treatment of pericarditis refer to general adult population. Few fragmentary data regarding recurrent in older adults exist. Objective Study Given absence specific scientific literature, we hypothesized that there might be clinical, laboratory outcome differences between young affected by idiopathic pericarditis. Materials Methods We performed an international multicentric retrospective cohort study analyzing from patients (idiopathic or post‐cardiac injury) referring tertiary referral centers. Clinical, laboratory, were compared younger than 65 years (controls) aged older. Results One hundred thirty‐three 142 controls enrolled. Comorbidities, including chronic kidney diseases, atrial fibrillation, diabetes, more present adults. The presenting symptom was dyspnea 54.1% versus 10.6% ( p < 0.001); pain 32.3% 80.3% 0.001). Fever higher 38°C 33.8% 53.5% = Pleural effusion prevalent (55.6% vs 34.5%, 0.001), as well severe pericardial (>20 mm) (24.1% 12.7%, 0.016) pericardiocentesis (16.5% 8.5%, 0.042). Blood leukocyte counts significantly lower (mean + SE: 10,227 289/mm 3 11,208 285/mm , 0.016). Concerning therapies, NSAIDS used 63.9% 0.003), colchicine 76.7% 87.3% 0.023), corticosteroids 49.6% 26.8% anakinra 14.3% 23.9% 0.044). Conclusions Older show a different clinical pattern, with frequent dyspnea, pleural effusion, fever count, making sometimes challenging. They received less NSAIDs colchicine, likely due comorbidities; they also treated commonly anti‐IL1 agents, frequently corticosteroids.

Language: Английский

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