The Role of cGAS-STING in Remodeling the Tumor Immune Microenvironment Induced by Radiotherapy

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: 209, P. 104658 - 104658

Published: Feb. 15, 2025

Language: Английский

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Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3834 - 3854

Published: June 3, 2024

Immunotherapy is an important cancer treatment method that offers hope for curing patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption the inability benefit majority of The success or failure closely linked tumor's immune microenvironment. Recently, there been significant attention on strategies regulate tumor microenvironment in order stimulate anti-tumor responses immunotherapy. distinctive physical properties and design flexibility nanomedicines have extensively utilized target cells (including tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor (MDSCs), fibroblasts (TAFs)), offering promising advancements In this article, we reviewed aimed at targeting various focus models are based nanomedicines, with goal inducing enhancing improve It worth noting combining other treatments, such as chemotherapy, radiotherapy, photodynamic therapy, can maximize therapeutic effects. Finally, identified challenges nanotechnology-mediated needs overcome more effective nanosystems.

Language: Английский

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Natural killer cell-derived exosome-based cancer therapy: from biological roles to clinical significance and implications

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 29, 2024

Abstract Natural killer (NK) cells are important immune in the organism and third major type of lymphocytes besides T B cells, which play an function cancer therapy. In addition to retaining tumor cell killing natural cell-derived exosomes also have characteristics high safety, wide source, easy preserve transport. At same time, modify, engineered can be used combination with a variety current therapies, not only enhances therapeutic efficacy, but significantly reduces side effects. Therefore, this review summarizes isolation modification strategies combined application other antitumor is expected accelerate clinical translation process

Language: Английский

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Targeting Triple NK Cell Suppression Mechanisms: A Comprehensive Review of Biomarkers in Pancreatic Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 515 - 515

Published: Jan. 9, 2025

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor outcomes due to frequent recurrence, metastasis, and resistance treatment. A major contributor this the tumor's ability suppress natural killer (NK) cells, which are key players in immune system's fight against cancer. In PDAC, tumor microenvironment (TME) creates conditions that impair NK cell function, including reduced proliferation, weakened cytotoxicity, limited infiltration. This review examines how interactions between tumor-derived factors, TME contribute progression treatment resistance. To address these challenges, we propose a new "Triple Cell Biomarker Approach". strategy focuses on identifying biomarkers from three critical areas: characteristics, suppression mechanisms. approach could guide personalized treatments enhance activity. Additionally, highlight potential of combining cell-based therapies conventional repurposed drugs improve for PDAC patients. While progress has been made, more research needed better understand dysfunction develop effective overcome barriers.

Language: Английский

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NK Cell-Microbiota Interaction Biomarker Strategy: Advancing Prostate Cancer Management

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 273 - 273

Published: Feb. 13, 2025

The role of natural killer (NK) cells in the management prostate cancer (PCa) remains incompletely understood. Some have proposed that measuring NK blood samples could serve as a reliable, minimally invasive tool for screening, assessing treatment effects, and predicting survival outcomes PCa patients. However, significance different cell phenotypes unclear. Given interplay between microbiome, we hypothesize combined signature derived from blood, along with microbiome profiles oral, urine, stool samples, surrogate marker activity tumor its microenvironment. Such an approach provides practical alternative to biopsies by enabling indirect assessment function tumors. Additionally, profiling their interactions microbiota has potential enhance prognostic accuracy guide development personalized therapeutic strategies. Prospective studies are needed validate utility assays management, focus on procedures predictive signatures outcomes.

Language: Английский

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The Role of NK Cells in Cancer Immunotherapy: Mechanisms, Evasion Strategies, and Therapeutic Advances

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 857 - 857

Published: April 2, 2025

Background/Objectives: Natural killer (NK) cells play a crucial role in tumor surveillance by exerting cytotoxic activity and modulating immune responses. However, tumors employ diverse evasion strategies that limit NK cell effectiveness. This review aims to explore the molecular mechanisms of activation inhibition cancer, influence microenvironment, latest advancements cell-based immunotherapies, including adoptive transfer Chimeric Antigen Receptor-Natural Killer (CAR-NK) therapies. Methods: A comprehensive literature was conducted, prioritizing peer-reviewed studies from last decade on biology, evasion, immunotherapeutic applications. The analysis includes data preclinical models clinical trials evaluating expansion strategies, cytokine-based stimulation, CAR-NK therapy developments. Results: eliminate through granule release, death receptor pathways, cytokine secretion. evade NK-mediated immunity downregulating activating ligands, secreting immunosuppressive molecules, altering microenvironment. Novel therapies, such as combination approaches with checkpoint inhibitors, enhance persistence therapeutic efficacy against both hematologic solid malignancies. Clinical suggest improved safety profiles compared CAR-T reduced release syndrome graft-versus-host disease. Conclusions: While immunotherapies hold great promise, challenges remain, limited tumor-induced immunosuppression. Addressing these hurdles will be critical for optimizing therapies advancing next-generation, off-the-shelf immunotherapeutics broader

Language: Английский

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Adoptive Immune Cell Therapy in Pediatric Solid Tumors

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

While the prognosis for pediatric solid tumors has improved in recent decades, patients with refractory, metastatic, or recurrent disease continue to face poor outcomes. Innovative therapeutic approaches like adoptive cell therapy (ACT) have emerged as a promising strategy overcome tumor evasion of immune system. However, targeting ACT been limited, cells employ various escape mechanisms, such downregulating antigens, creating an immunosuppressive microenvironment by secreting anti-inflammatory cytokines and expressing checkpoint inhibitors that can suppress responses. This review aims highlight progress challenges immunotherapy tumors, focusing on new perspectives this patient population.

Language: Английский

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