The antioxidant barrier, oxidative/nitrosative stress, and protein glycation in allergy: from basic research to clinical practice DOI Creative Commons
Grzegorz Biedrzycki, Blanka Wolszczak-Biedrzycka, Justyna Dorf

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 5, 2024

Recent studies indicate that oxidative/nitrosative stress is involved in the pathogenesis of asthma, allergic rhinitis, atopic dermatitis, and urticaria. The article aimed to review latest literature on disruptions redox homeostasis protein glycation allergy patients. It has been shown enzymatic non-enzymatic antioxidant systems are impaired conditions, which increases cell susceptibility oxidative damage. Reactive oxygen/nitrogen species exacerbate severity asthma symptoms by activating inflammatory mediators cause airway smooth muscle contraction, promote mucus hypersecretion, increase permeability lung capillaries, damage membranes. Redox biomarkers could have considerable diagnostic potential There no compelling evidence antioxidants reduce symptoms' or slow disease progression.

Language: Английский

Diagnostic Markers of Severe COVID‐19 and Community‐Acquired Pneumonia in Children From Southern India DOI Open Access
Tina Damodar, Lonika Lodha,

Sourabh Suran

et al.

Microbiology and Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

COVID-19 severely impacts children in India, with many developing severe pneumonia or multisystem inflammatory syndrome (MIS-C). Concurrently, non-COVID-19 respiratory viruses causing community-acquired (CAP) have resurged. These conditions present similarly, challenging accurate diagnosis. This study aims to compare markers and clinical parameters pneumonia, CAP, COVID-associated MIS-C. We assessed 12 mediators serum from 14 16 9 Clinical characteristics routine laboratory findings at admission were recorded. Children MIS-C had significantly higher levels of IL-1RA, IL-8, TNF compared those pneumonia; CCL2, HGF, M-CSF, IL-8 CAP. GROα tended be pneumonia. presentations similar, but patients distinct findings, including lower platelet counts albumin levels, creatinine liver enzyme levels. exhibited a unique profile. emerged as potential biomarker for MIS-C, while increased merit further exploration. Combining may improve the diagnosis differentiation these conditions, enhancing patient management.

Language: Английский

Citations

0
Neutrophils and COVID-19 DOI
Jasmin Šutković

Progress in molecular biology and translational science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Association of inflammation and protein carbamylation in patients with COVID-19 DOI Creative Commons

Jolanta Smykiewicz,

Ryszard Tomasiuk,

Roman Cemaga

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 2, 2025

Carbamylation involves the non-enzymatic binding of isocyanic acid to amino groups proteins, making it associated with many pathological conditions, including inflammation, aging, arteriosclerosis, and renal failure. However, there are no data on protein carbamylation in patients COVID-19. Our study is first evaluate association between blood inflammation who died from COVID-19 compared survivors. The included 50 admitted Dr. Tytus Chałubiński Specialist Hospital Radom, Poland. Twenty-five them were survivors (15 men, 10 women), 25 deceased women). number subjects was based a pilot assuming significance level 0.05 test power 0.8. Plasma/serum samples assayed for carbamyl-lysine (CBL) inflammatory biomarkers (CRP, procalcitonin, D-dimer, IL-6, WBC). concentration CBL measured using an enzyme-linked immunosorbent assay (ELISA). Statistical analysis performed Mann-Whitney U Spearman rank correlation. Receiver Operating Characteristic (ROC) used assess diagnostic utility serum CBL. Serum levels significantly higher (p = 0.0011). There positive correlation WBC. >101 ng/mL, moderate sensitivity specificity, differentiate recovered (area under curve 0.76). In conclusion, excessive carbamylation. Inflammation may be source production A thorough understanding consequences increased clarify complications.

Language: Английский

Citations

0
Significance of nitrosative stress and glycoxidation products in the diagnosis of COVID-19 DOI Creative Commons
Blanka Wolszczak-Biedrzycka, Justyna Dorf, Joanna Matowicka-Karna

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 22, 2024

Abstract Nitrosative stress promotes protein glycoxidation, and both processes can occur during an infection with the SARS-CoV-2 virus. Therefore, aim of this study was to assess selected nitrosative parameters glycoxidation products in COVID-19 patients convalescents relative healthy subjects, including reference severity symptoms. The diagnostic utility biomarkers also evaluated patients. involved 218 COVID-19, 69 convalescents, 48 subjects. (NO, S-nitrosothiols, nitrotyrosine) (tryptophan, kynurenine, N-formylkynurenine, dityrosine, AGEs) were measured blood plasma or serum use colorimetric/fluorometric methods. levels NO ( p = 0.0480), S-nitrosothiols 0.0004), nitrotyrosine 0.0175), kynurenine < 0.0001), N-formylkynurenine dityrosine AGEs 0.0001) significantly higher, whereas tryptophan fluorescence lower than control group. Significant differences analyzed observed different stages COVID-19. In turn, concentrations controls. ROC analysis revealed that be useful for diagnosing infections virus because they differentiate (KN: sensitivity—91.20%, specificity—92.00%; NFK: sensitivity—92.37%, AGEs: sensitivity—99,02%, specificity—100%) sensitivity—82.22%, specificity—84.00%; sensitivity—82,86%, specificity—86,00%; DT: sensitivity—100%, specificity—100%; AGE: from subjects high sensitivity specificity. are intensified after redox fluctuate disease. Circulating stress/protein have potential convalescents.

Language: Английский

Citations

3
The antioxidant barrier, oxidative/nitrosative stress, and protein glycation in allergy: from basic research to clinical practice DOI Creative Commons
Grzegorz Biedrzycki, Blanka Wolszczak-Biedrzycka, Justyna Dorf

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 5, 2024

Recent studies indicate that oxidative/nitrosative stress is involved in the pathogenesis of asthma, allergic rhinitis, atopic dermatitis, and urticaria. The article aimed to review latest literature on disruptions redox homeostasis protein glycation allergy patients. It has been shown enzymatic non-enzymatic antioxidant systems are impaired conditions, which increases cell susceptibility oxidative damage. Reactive oxygen/nitrogen species exacerbate severity asthma symptoms by activating inflammatory mediators cause airway smooth muscle contraction, promote mucus hypersecretion, increase permeability lung capillaries, damage membranes. Redox biomarkers could have considerable diagnostic potential There no compelling evidence antioxidants reduce symptoms' or slow disease progression.

Language: Английский

Citations

1