Editorial: Regulatory immune cells in organ transplantation DOI Creative Commons
Hongxuan Ma, Jiajia Sun, Xiaohu Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 20, 2024

Keywords: regulatory immune cells, organ transplantation, tolerance, immunosuppression, response

Language: Английский

Cellular interactions in self-directed immune mediated liver diseases DOI Creative Commons
Amber Bozward, Scott Davies, Sean Michael Morris

et al.

Journal of Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Infiltrating T lymphocytes and tumor microenvironment within cholangiocarcinoma: immune heterogeneity, intercellular communication, immune checkpoints DOI Creative Commons
Yunyan Dai, Chenyang Dong, Zhiming Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

Cholangiocarcinoma is the second most common primary liver cancer, and its global incidence has increased in recent years. Radical surgical resection systemic chemotherapy have traditionally been standard treatment options. However, complexity of cholangiocarcinoma subtypes often presents a challenge for early diagnosis. Additionally, high recurrence rates following radical resistance to late-stage limit benefits patients. Immunotherapy emerged as an effective strategy treating various types shown efficacy when combined with cholangiocarcinoma. Current immunotherapies targeting predominantly focused on T lymphocytes within tumor microenvironment, new yielded unsatisfactory results clinical trials. Therefore, it essential achieve comprehensive understanding unique microenvironment pivotal role it. In this review, we describe heterogeneous immune landscape intercellular communication summarize specific distribution lymphocytes. Finally, review potential checkpoints

Language: Английский

Citations

0
Exploiting regulatory T cells (Tregs): Cutting-edge therapy for autoimmune diseases DOI Creative Commons
Marwa Hassan, Mohamed Elzallat, Dina Mostafa Mohammed

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114624 - 114624

Published: April 10, 2025

Regulatory T cells (Tregs) are a specialized subset of suppressive that essential for maintaining self-tolerance, regulating effector cells, managing microbial infections, preventing tumors, allergies, and autoimmune disorders, facilitating allograft transplantation. Disruptions in Treg function or abundance contribute to an imbalance between pathogenic protective immune diseases. Recently, one promising treatment strategy restore balance involves the selective expansion manipulation Tregs using low-dose IL-2 therapy, adoptive cell transfer, chimeric antigen receptor (CAR)-Treg approaches. have been shown increasing number research studies prevent even treat variety such as allergic diseases, transplant rejection, graft-versus-host disease. A thorough comprehension is anticipated provide clear prospects effective immunotherapy wide range This review provides overview biology, including their functions, mechanisms, phenotypic markers, well involvement disease settings. Furthermore, we discuss therapeutic potential different subpopulations translational applications

Language: Английский

Citations

0
Immunology of Autoimmune Liver Diseases DOI
Kayani Kayani, Amber Bozward, Scott Davies

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Immune Monitoring after Cell Therapy and Hematopoietic Cell Transplantation: Guidelines by the ISCT Stem Cell Engineering Committee DOI Creative Commons

Linda Oppizzi,

Kinga Hosszu, Susan E. Prockop

et al.

Cytotherapy, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Low IL-35 Expression in CSF is Associated with Neuro-Behcet Disease: Comparative Analysis Between Parenchymal and Non-Parenchymal NBD DOI
Kamel Hamzaoui,

Fayçal Haj Sassi,

Mariem Salhi

et al.

Immunology Letters, Journal Year: 2025, Volume and Issue: unknown, P. 107031 - 107031

Published: May 1, 2025

Language: Английский

Citations

0
“A Splice of Life: The Discovery, Function, and Clinical Implications of FOXP3 Isoforms in Autoimmune Disease” DOI Creative Commons

Kristin N Weinstein,

Phillip P. Domeier, Steven F. Ziegler

et al.

International Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Regulatory T cells (Tregs) are a specialized subset of CD4+ essential for the maintenance immune homeostasis and prevention autoimmunity. Treg lineage functions programmed by X-chromosome encoded transcription factor Forkhead box P3 (FOXP3). In humans, multiple FOXP3 isoforms generated through alternative splicing. A full-length isoform containing all coding exons (FOXP3-FL) version lacking second exon (FOXP3-ΔE2) predominant isoforms. Additionally, there two minor either 7 (FOXP3-ΔE7) both 2 (FOXP3-ΔE2ΔE7). Although healthy humans express approximately equal levels FOXP3-FL FOXP3-ΔE2 isoforms, sole expression results in development systemic autoimmune disease that resembles dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. These clinical observations strongly suggest functional defects suppression Tregs isoform. Work from past decades has provided phenotypic evidence differences between FOXP3-FL, FOXP3-ΔE2, FOXP3-ΔE7 this review, we discuss discovery phenotype function different role these known to play

Language: Английский

Citations

2
Editorial: Regulatory immune cells in organ transplantation DOI Creative Commons
Hongxuan Ma, Jiajia Sun, Xiaohu Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 20, 2024

Keywords: regulatory immune cells, organ transplantation, tolerance, immunosuppression, response

Language: Английский

Citations

0