Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: July 10, 2024
Extensive research efforts have been dedicated to elucidating the intricate pathways by which gastrointestinal microbiota and their metabolites exert influence on processes of bone formation. Nonetheless, a notable gap exists in literature concerning bibliometric analysis trends at nexus metabolism.
Language: Английский
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 692 - 692
Published: May 27, 2024
There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in broad range characteristics and biological effects. Polyphenols can be found foods drinks, including fruits, cereals, tea, coffee. Studies both vitro vivo, well clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, health advantages. Dietary polyphenols demonstrated the potential to prevent many problems, obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, neurological diseases. In this paper, protective effects mechanisms behind them investigated detail, citing most recent available literature. This review aims provide comprehensive overview current knowledge on role preventing managing chronic The cited publications derived from vitro, human-based studies trials. A more complete understanding these naturally occurring metabolites will pave way for development novel polyphenol-rich diet drug programs. This, turn, provides further evidence their benefits.
Language: Английский
Citations
21
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: Oct. 10, 2024
The interplay between the human microbiome and musculoskeletal system represents a burgeoning field of research with profound implications for understanding treating disorders. This review articulates pivotal role in modulating bone health, highlighting gut-bone axis as critical nexus potential therapeutic intervention. Through meticulous analysis recent clinical research, we underscore microbiome's influence on osteoporosis, sarcopenia, osteoarthritis, rheumatoid arthritis, delineating both direct indirect mechanisms by which microbiota could impact integrity function. Our investigation reveals novel insights into microbiota's contribution to density regulation, hormone production, immune modulation, nutrient absorption, laying groundwork innovative microbiome-based strategies disease management. Significantly, identify challenges hindering translation practice, including limitations current microbial sequencing techniques need standardized methodologies studies. Furthermore, highlight promising directions future particularly realm personalized medicine, where variability offers unique opportunities tailored treatment approaches. sets new agenda leveraging gut diagnosis, prevention, conditions, marking step toward integrating science care.
Language: Английский
Citations
6
Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1220 - 1220
Published: April 19, 2024
Type 2 diabetes mellitus (T2DM) presents a challenge for individuals today, affecting their health and life quality. Besides its known complications, T2DM has been found to contribute bone/mineral abnormalities, thereby increasing the vulnerability bone fragility/fractures. However, there is still need appropriate diagnostic approaches targeted medications address T2DM-associated diseases. This study aims investigate relationship between changes in gut microbiota, T2DM, osteoporosis. To explore this, rat model was induced by combining high-fat diet low-dose streptozotocin treatment. Our findings reveal that rats have lower mass reduced levels of turnover markers compared control rats. We also observe significant alterations microbiota rats, characterized higher relative abundance Firmicutes (F) Proteobacteria (P), but Bacteroidetes (B) at phylum level. Further analysis indicates correlation F/B ratio levels, as well B/P HbA1c levels. Additionally, genus level, we an inverse
Language: Английский
Citations
4
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 233 - 256
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1951 - 1967
Published: Feb. 1, 2025
Abstract: Osteoarthritis (OA) is a common degenerative joint disease characterized by the progressive degradation of articular cartilage, synovial inflammation, and subchondral bone remodeling. This review explores interplay between aging, PANoptosis, inflammation in OA progression. Age-related cellular immune dysfunctions, including senescence, senescence-associated secretory phenotypes (SASPs), immunosenescence, significantly contribute to degeneration. In OA, dysregulated apoptosis, necroptosis, pyroptosis, particularly chondrocytes, exacerbate cartilage damage. Apoptosis, mediated JNK pathway, reduces chondrocyte density, while necroptosis involving RIPK-1/RIPK-3 NLRP3 inflammasome, respectively, amplify destruction. Inflammatory cytokines damage-associated molecular patterns (DAMPs) further enhance these PANoptotic pathways. Current therapeutic strategies primarily focus on anti-inflammatory agents such as non-steroidal drugs (NSAIDs) corticosteroids, with growing interest anti-senescence targeting senescence SASP. Additionally, exploring PANoptosis mechanisms offers potential for innovative treatments. Keywords: osteoarthritis,
Language: Английский
Citations
0
Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(8), P. 332 - 332
Published: July 25, 2024
Due to the challenge of weaning pigs and need reduce use antimicrobials in animal feed, there is a growing look for nutraceutical alternatives adverse effects post-weaning period. We evaluate effect different feed additives on microbial communities, gut health biomarkers, productivity during The study involved 240 piglets weaned 21st day age randomized six diets: D1-BD commercial standard D2-AGP: D1 + 150 ppm zinc bacitracin, D3-MD: 550 maltodextrin, D4-FOS: 300 fructo-oligosaccharides, D5-EO: 70
Language: Английский
Citations
2
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(19), P. 5977 - 5977
Published: Oct. 8, 2024
modulation of gut microbiota by probiotics has been proposed as a target for intervention to reduce bone mineral density (BMD) loss in the postmenopausal period. This study aims evaluate effect
Language: Английский
Citations
2
Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3587 - 3587
Published: Oct. 22, 2024
In degenerative joint disease like osteoarthritis (OA), bioactive compounds resveratrol, epigallocatechin gallate, curcumin, and other polyphenols often target various signalling pathways, including NFκB, TGFβ, Wnt/β-catenin by executing epigenetic-modifying activities. Epigenetic modulation can genes of pathophysiology via histone modification, promoter DNA methylation, non-coding RNA expression, some which are directly involved in OA but have been less explored. patients seek options that improve the quality their life addition to existing treatment with nonsteroidal anti-inflammatory drugs (NSAIDs). Although natural exhibit therapeutic potential against OA, several disadvantages loom, insolubility poor bioavailability. Nanoformulated promise a better way alleviate since they also control systemic events, metabolic, immunological, inflammatory responses, modulating host gut microbiota regulate pathogenesis. Recent data suggest dysbiosis OA. However, limited evidence is available on role as epigenetic modulators ameliorating Moreover, it not known whether effects polyphenolic microbial response mediated modulatory activities This narrative review highlights nanotherapeutic strategies utilizing compounds, reporting chondrocyte growth, metabolism, modifications amelioration.
Language: Английский
Citations
2
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: July 10, 2024
Extensive research efforts have been dedicated to elucidating the intricate pathways by which gastrointestinal microbiota and their metabolites exert influence on processes of bone formation. Nonetheless, a notable gap exists in literature concerning bibliometric analysis trends at nexus metabolism.
Language: Английский
Citations
1