Nutraceuticals as Modulators of Molecular Placental Pathways: Their Potential to Prevent and Support the Treatment of Preeclampsia DOI Open Access

Patrycja Bukowska,

Michalina Bralewska, Tadeusz Pietrucha

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12167 - 12167

Published: Nov. 13, 2024

Preeclampsia (PE) is a serious condition characterized by new-onset hypertension and proteinuria or organ dysfunction after the 20th week of gestation, making it leading cause maternal fetal mortality worldwide. Despite extensive research, significant gaps remain in understanding mechanisms underlying PE, contributing to ineffectiveness current prevention treatment strategies. Consequently, premature cesarean sections often become primary intervention safeguard health. Emerging evidence indicates that placental insufficiency, driven molecular disturbances, plays central role development PE. Additionally, microbiome may be implicated pathomechanism preeclampsia secreting metabolites influence inflammation oxidative stress, thereby affecting Given limitations pharmaceuticals during pregnancy due potential risks concerns about teratogenic effects, nutraceuticals provide safer alternatives. Nutraceuticals are food products dietary supplements offer health benefits beyond basic nutrition, including plant extracts probiotics. Their historical use traditional medicine has provided valuable insights into their safety efficacy, for pregnant women. This review will examine how adoption can enhance dysregulated pathways, potentially offering preeclampsia.

Language: Английский

C3AR1 as a target for preeclampsia: from bioinformatics and network pharmacology to experimental validation DOI Creative Commons
Yongfeng Hu, Shaoqiang Li, Hong Yan

et al.

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 30, 2025

Preeclampsia, characterized by hypertension and proteinuria during pregnancy, poses significant risks to both mother fetus. The complement system's aberrant activation, notably the C3AR1, is important pathogenesis of preeclampsia, although precise mechanisms are not fully understood. Utilizing Comparative Toxicogenomics Database (CTD) Molecular Signatures (MSigDB), we identified system targets associated with preeclampsia environmental pollutants. Expression validation was conducted through Gene Omnibus (GEO) database. docking predicted interactions between BPA, PFOS, C3AR1. Immunohistochemical staining 80 placental tissues (40 early-onset 40 healthy controls) confirmed C3AR1 expression its clinical correlation. Integrated bioinformatics analyses revealed C3AR1's role in preeclampsia's molecular mechanisms. Functional verification assessed knocking down HTR-8/Svneo cells, including cell proliferation, invasion, apoptosis. Network pharmacology established connections pollutants as a key target. BPA PFOS binding Reduced preeclamptic placentas correlated maternal blood pressure, showed high diagnostic potential (AUC = 0.95). involvement linked Jak-STAT, TGF-β, HIF-1 pathways, NK M1 macrophage activity. knockdown cells decreased proliferation increased diminished tissues, correlating disease severity, suggesting biomarker. It crucial for cellular functions inflammation, future studies aiming leverage this novel treatments. Not applicable.

Language: Английский

Citations

0
A Two-Sample Mendelian Randomization Study of Basophil Count and Risk of Gestational Diabetes Mellitus DOI Creative Commons
Jing Mao, Yanqiong Gan, Xiao Tan

et al.

International Journal of Women s Health, Journal Year: 2025, Volume and Issue: Volume 17, P. 517 - 527

Published: Feb. 1, 2025

High basophil count levels are associated with an increased risk of gestational diabetes mellitus (GDM). We used two-sample Mendelian randomisation (MR) to explore a potential causal relationship. It also aims offer genetic evidence supporting the link between and development while addressing issues confounding reverse causality commonly encountered in observational studies. utilized publically accessible summary information obtained from genome-wide association studies (GWAS) for conducting randomization (TSMR) study. The major analysis method employed was inverse variance weighted (IVW), whereas other four methods, namely median method, MR-Egger regression, simple model model, were as supplemental analyses. investigated relationship GDM opposite direction using directional validation MR analysis. Furthermore, R package "ClusterProfiler" conduct Kyoto Encyclopedia Genes Genomes (KEGG) pathways Gene Ontology (GO) terms used. Additionally, help STRING database, we have constructed network protein-protein interactions (PPIs). Inverse Variance Weighted (IVW) revealed significant (OR, 0.84; 95% CI; 0.74-0.96; P, 0.01). A sensitivity performed assess reliability results, indicating no indication pleiotropy or heterogeneity, hence strengthening validity findings. causation predisposition on counts not supported by results this study showed high but did support susceptibility counts.

Language: Английский

Citations

0
JAK inhibitors and pregnancy in autoimmune disease: safety insights from existing evidence DOI Creative Commons

Hanjing Huang,

Yunuo Wang,

Luyao Han

et al.

Expert Opinion on Drug Safety, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 3

Published: March 10, 2025

Language: Английский

Citations

0
Associations Between Follicular Fluid Biomarkers and IVF/ICSI Outcomes in Normo-Ovulatory Women—A Systematic Review DOI Creative Commons
Soha Albeitawi,

Saif-Ulislam Bani-Mousa,

Baraa Jarrar

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 443 - 443

Published: March 20, 2025

(1) Background: The follicular fluid (FF) comprises a large portion of ovarian follicles, and serves as both communication growth medium for oocytes, thus should be representative the metabolomic status follicle. This review aims to explore FF biomarkers well their effects on fertilization, oocyte, embryo development, later implantation maintenance pregnancy. (2) Methods: was registered in PROSPERO database with ID: CRD42025633101. We parsed PubMed, Scopus, Google Scholar research different IVF/ICSI outcomes normo-ovulatory women. Included studies were assessed risk bias using NOS scale. Data extracted tabulated by two independent researchers. (3) Results: 22 included articles, sample size range 31 414 median 60 participants, contained 61 biomarkers, including proteins, factors, steroid polypeptide hormones, inflammation oxidative stress markers, amino acids, vitamins, lipids types, miRNAs. Most studied had significant outcomes, seem have roles various cellular pathways responsible oocyte growth, implantation, placental formation, metabolome also seems interconnected, its components influencing levels activities each other through feedback loops. (4) Conclusions: can utilized diagnostic therapeutic purposes IVF; however, further are required choosing most promising ones due heterogeneity results. Widespread adoption LC-MS miRNA microarrays help quantify metabolome, we see great potential vitro supplementation (IVS) some improving outcomes.

Language: Английский

Citations

0
Expression Patterns of miR‐29b and miR‐148a in Colostrum of Awassi Sheep With Higher Immunoglobulin G Levels DOI Creative Commons
Hüseyin Özkan, Ufuk Kaya, Hasan Hüseyin Keçeli

et al.

Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(3)

Published: April 4, 2025

This study aimed to investigate the compositional parameters and expression patterns of miR-29b miR-148a in sheep colostrum containing low high levels Immunoglobulin G (IgG). Blood samples were collected within first 6 h following birth from 24 pregnant Awassi sheep. On basis determined IgG levels, (Low [LIGG], 44.83 ± 4.97 mg/mL) (High [HIGG], 80.71 3.31 groups formed. In addition measuring parameters, expressions plasma colostrum. Although somatic cell score (SCS), pH electrical conductivity (EC) higher, fat-free dry matter (FFDM), protein, lactose freezing point lower HIGG group. Compared LIGG, was downregulated approximately 5-fold HIGG, whereas more than 3-fold There negative correlations between IgG, SCS pH. Colostrum positively correlated with negatively FFDM, protein lactose. Area under curve (AUC) values SCS, pH, lactose, point, EC (colostrum) significant. Sensitivity specificity 100% 66.7%, 81.8% 66.7% (Colostrum) 75% LIGG. According results, might be an important molecular target for lamb development, could a potential biomarker quality. Moreover, showed that useful diagnostic status because higher sensitivity rates AUC values.

Language: Английский

Citations

0
Extracellular Vesicles Alter Trophoblast Function in Pregnancies Complicated by COVID‐19 DOI Creative Commons
Thea Golden, Sneha Mani, Rebecca L. Linn

et al.

Journal of Extracellular Vesicles, Journal Year: 2025, Volume and Issue: 14(4)

Published: April 1, 2025

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and resulting disease (COVID‐19) cause placental dysfunction, which increases the risk of adverse pregnancy outcomes. While abnormal pathology from COVID‐19 is common, direct placenta rare. This suggests that pathophysiology associated with maternal COVID‐19, rather than infection, responsible for dysfunction. We hypothesized circulating extracellular vesicles (EVs), altered by during pregnancy, contribute to To examine this hypothesis, we characterized EVs pregnancies complicated tested their effects on trophoblast cell physiology in vitro. Trophoblast exposure isolated patients an active (AI), but not controls, key functions including hormone production invasion. Thus, participants AI, both symptomatic asymptomatic cases, can disrupt vital functions. EV cargo differed between depending gestational timing Controls, may disruption transcriptome morphology. Our findings show have throughout EVs, are likely participate dysfunction induced COVID‐19.

Language: Английский

Citations

0
Decoding the molecular pathways governing trophoblast migration and placental development; a literature review DOI Creative Commons
Lianlian Liu, Lin Tang, Daiwen Chen

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 27, 2024

Placental development is a multifaceted process critical for fruitful pregnancy, reinforced by complex network of molecular pathways that synchronize trophoblast migration, differentiation, and overall placental function. This review provides an in-depth analysis the key signaling pathways, such as Wnt, Notch, TGF-β, VEGF, which play fundamental roles in proliferation, invasion, complicated vascular development. For instance, Wnt pathway essential to balance stem cell proliferation while Notch stimulates fate decisions invasive behavior. TGF-β plays role invasion predominantly response low oxygen environment early regulated hypoxia-inducible factors (HIFs). These promote adaptation, ensure proper attachment vascularization, facilitate adequate fetal-maternal exchange. Further, we explore epigenetic post-transcriptional regulatory mechanisms regulate function, including DNA methylation contribution non-coding RNAs, contribute fine-tuning gene expression during Dysregulation these associated with severe pregnancy complications, preeclampsia, intrauterine growth restriction, recurrent miscarriage, emphasizing need targeted therapeutic strategies. Finally, emerging technologies like organoids, single-cell RNA sequencing, placenta-on-chip models are discussed innovative tools hold promise advancing our understanding biology developing novel interventions improve outcomes. emphasizes importance better address dysfunctions disorders.

Language: Английский

Citations

1
Exploring the Role of Endoplasmic Reticulum Stress in Recurrent Spontaneous Abortion: Identification of Diagnostic Biomarkers and Immune Cell Interactions DOI Creative Commons
Tao Tang,

Jingyu Fu,

Chong Zhang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38964 - e38964

Published: Oct. 1, 2024

Language: Английский

Citations

0
Nutraceuticals as Modulators of Molecular Placental Pathways: Their Potential to Prevent and Support the Treatment of Preeclampsia DOI Open Access

Patrycja Bukowska,

Michalina Bralewska, Tadeusz Pietrucha

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12167 - 12167

Published: Nov. 13, 2024

Preeclampsia (PE) is a serious condition characterized by new-onset hypertension and proteinuria or organ dysfunction after the 20th week of gestation, making it leading cause maternal fetal mortality worldwide. Despite extensive research, significant gaps remain in understanding mechanisms underlying PE, contributing to ineffectiveness current prevention treatment strategies. Consequently, premature cesarean sections often become primary intervention safeguard health. Emerging evidence indicates that placental insufficiency, driven molecular disturbances, plays central role development PE. Additionally, microbiome may be implicated pathomechanism preeclampsia secreting metabolites influence inflammation oxidative stress, thereby affecting Given limitations pharmaceuticals during pregnancy due potential risks concerns about teratogenic effects, nutraceuticals provide safer alternatives. Nutraceuticals are food products dietary supplements offer health benefits beyond basic nutrition, including plant extracts probiotics. Their historical use traditional medicine has provided valuable insights into their safety efficacy, for pregnant women. This review will examine how adoption can enhance dysregulated pathways, potentially offering preeclampsia.

Language: Английский

Citations

0