Journal of Cellular Physiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
ABSTRACT
Immunometabolism
is
an
emerging
growing
field
that
focuses
on
the
role
of
cellular
metabolism
in
regulation
immune
cell
function
and
fate.
Thus,
proliferation,
differentiation,
activation,
populations
are
modulated
by
reprogramming
their
fueling
metabolic
pathways.
Pregnancy
entails
a
fine
maternal−fetal
interaction
to
assist
energetic
demands
fetus
where
trophoblast
cells
have
central
role.
Maternal
neutrophil
functional
shaping
has
been
proposed
though
conditioning
during
pregnancy
not
studied
yet.
Here,
we
explored
effects
trophoblast‐derived
factors
rewiring
neutrophils
from
nonpregnant
women
its
impact
functions
like
reactive
oxygen
species
(ROS)
production,
extracellular
trap
(NET)
release,
migration.
In
parallel,
immunometabolic
status
isolated
pregnant
(16−20
weeks)
was
compared
with
age‐matched
control
samples.
Trophoblast‐derived
induced
glucose
uptake
lipid
droplet
accumulation
without
activating
ROS
production
or
NET
release.
Conditioned
media
also
inhibited
PMA‐induced
NETosis
partly
impairing
neutrophils.
turn,
had
increased
basal
accumulation,
women,
accompanied
higher
release
NETs.
Interestingly,
NETs
blocked
fatty
acid
oxidation
inhibitor
indicating
contribution
activity
pregnancy.
Results
consistent
mechanisms
underlying
point
out
profiling.
These
findings
provide
novel
clues
understand
homeostasis
maintenance
raise
clinical
potential
monitoring
normal
complicated
pregnancies.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8098 - 8098
Published: July 25, 2024
In
recent
years,
the
incidence
of
metabolic
syndrome
(MS)
has
increased
due
to
lifestyle-related
factors
in
developed
countries.
MS
represents
a
group
conditions
that
increase
risk
diabetes,
cardiovascular
diseases,
and
other
severe
health
problems.
Low-grade
chronic
inflammation
is
now
considered
one
key
aspects
could
be
defined
as
new
factor.
Indeed,
an
visceral
adipose
tissue,
typical
obesity,
contributes
development
inflammatory
state,
which,
turn,
induces
production
several
proinflammatory
cytokines
responsible
for
insulin
resistance.
Psoriasis
relapsing
skin
disease
characterized
by
release
pro-inflammatory
cytokines,
which
can
contribute
different
pathological
within
spectrum
MS.
A
link
between
disorders
emerged
from
evidence
indicating
weight
loss
obtained
through
healthy
diets
exercise
was
able
improve
clinical
course
therapeutic
response
patients
with
obesity
or
overweight
even
prevent
its
occurrence.
factor
this
balance
gut
microbiota;
it
extremely
dynamic
system,
makes
manipulation
diet
possible
via
probiotic,
prebiotic,
symbiotic
compounds.
Given
this,
microbiota
additional
target
metabolism
conditions.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 29, 2024
Myeloid-derived
suppressor
cells
(MDSC)
are
considered
an
aberrant
population
of
immature
myeloid
that
have
attracted
considerable
attention
in
recent
years
due
to
their
potent
immunosuppressive
activity.
These
typically
absent
or
present
very
low
numbers
healthy
individuals
but
become
abundant
under
pathological
conditions
such
as
chronic
infection,
inflammation
and
cancer.
The
activity
MDSC
helps
control
excessive
immune
responses
might
otherwise
lead
tissue
damage.
This
same
can
be
detrimental,
particularly
cancer
infection.
In
the
setting,
tumors
secrete
factors
promote
expansion
recruitment
MDSC,
thereby
creating
a
local
environment
favors
tumor
progression
by
inhibiting
effective
against
cells.
has
made
target
interest
therapy,
with
researchers
exploring
strategies
inhibit
function
reduce
improve
efficacy
immunotherapies.
context
infections,
persistent
infections
suppressing
protective
preventing
clearance
pathogens.
Therefore,
targeting
may
provide
novel
approach
pathogen
during
infections.
Ongoing
research
on
aims
elucidate
exact
processes
behind
expansion,
recruitment,
activation
suppressive
mechanisms.
this
context,
it
is
becoming
increasingly
clear
metabolism
closely
linked
function.
For
example,
exhibit
high
rates
glycolysis,
which
not
only
provides
energy
also
generates
metabolites
facilitate
addition,
fatty
acid
metabolic
pathways,
oxidation
(FAO),
been
implicated
regulation
Furthermore,
amino
metabolism,
arginine
mediated
enzymes
arginase-1,
plays
critical
role
MDSC-mediated
immunosuppression.
review,
we
discuss
signature
highlight
therapeutic
implications
modulate
functions.
Journal of Biological Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 108091 - 108091
Published: Dec. 1, 2024
Neutrophils
are
a
part
of
the
innate
immune
system
and
produce
reactive
oxygen
species
(ROS)
to
extinguish
pathogens.
The
major
source
ROS
in
neutrophils
is
NADPH
oxidase,
which
fueled
by
generated
via
pentose
phosphate
pathway;
however,
it
unclear
how
other
accessory
glucose
metabolism
pathways
mitochondrial
activity
influence
respiratory
burst.
We
examined
temporal
dynamics
burst
delineated
changes
over
time
after
neutrophil
activation.
Bone
marrow-derived
were
stimulated
with
phorbol
12-myristate
13-acetate
(PMA),
was
measured
extracellular
flux
analysis.
Metabolomics
experiments
utilizing
Biology,
Journal Year:
2024,
Volume and Issue:
13(10), P. 773 - 773
Published: Sept. 27, 2024
The
innate
immune
system
(IIS)
is
an
ancient
and
essential
defense
mechanism
that
protects
animals
against
a
wide
range
of
pathogens
diseases.
Although
extensively
studied
in
mammals,
our
understanding
the
IIS
other
taxa
remains
limited.
zebrafish
(
International Immunopharmacology,
Journal Year:
2024,
Volume and Issue:
143, P. 113504 - 113504
Published: Oct. 30, 2024
Nicotinamide
adenine
dinucleotide
phosphate
oxidase
complex
2
(NOX2)
is
an
effector
molecule
expressed
predominantly
in
neutrophils.
Its
deficiency
present
immune
disorders,
including
systemic
lupus
erythematosus,
chronic
granulomatous
disease,
and
rheumatoid
arthritis.
Recent
reports
indicated
that
NOX2
regulates
autoimmunity
programmed
cell
death.
However,
the
exact
mechanism
unclear.
In
this
study,
we
explored
effect
of
on
neutrophil
apoptosis.
We
demonstrated
caused
pyroptosis.
Mechanistically,
inhibitor
GSK2795039
application
or
knockdown
components
resulted
increased
mitochondrial
ROS,
inhibition
AMP-activated
protein
kinase
(AMPK),
activation
Gasdermin
E.
AMPK
activators,
metformin
epigallocatechin
gallate,
inhibited
deficient
NOX2-induced
Together,
these
findings
illustrate
involvement
regulating
death
emphasize
its
importance
autoimmunity.
Journal of Thoracic Disease,
Journal Year:
2024,
Volume and Issue:
16(10), P. 6496 - 6515
Published: Oct. 1, 2024
The
unfolded
protein
response
(UPR)
is
a
critical
biological
process
related
to
variety
of
physiological
functions
and
cardiac
disease.
However,
the
role
UPR-related
genes
in
acute
myocardial
infarction
(AMI)
has
not
been
well
characterized.
Therefore,
this
study
aims
elucidate
mechanism
UPR
context
AMI.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 8, 2024
Osteosarcoma,
a
highly
aggressive
malignant
bone
tumor,
is
significantly
influenced
by
the
intricate
interactions
within
its
tumor
microenvironment
(TME),
particularly
involving
neutrophils.
This
review
delineates
multifaceted
roles
of
neutrophils,
including
tumor-associated
neutrophils
(TANs)
and
neutrophil
extracellular
traps
(NETs),
in
osteosarcoma’s
pathogenesis.
TANs
exhibit
both
pro-
anti-tumor
phenotypes,
modulating
growth
immune
evasion,
while
NETs
facilitate
cell
adhesion,
migration,
immunosuppression.
Clinically,
neutrophil-related
markers
such
as
neutrophil-to-lymphocyte
ratio
(NLR)
predict
patient
outcomes,
highlighting
potential
for
neutrophil-targeted
therapies.
Unraveling
these
complex
crucial
developing
novel
treatment
strategies
that
harness
TME
to
improve
osteosarcoma
management.
Journal of Cellular Physiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
ABSTRACT
Immunometabolism
is
an
emerging
growing
field
that
focuses
on
the
role
of
cellular
metabolism
in
regulation
immune
cell
function
and
fate.
Thus,
proliferation,
differentiation,
activation,
populations
are
modulated
by
reprogramming
their
fueling
metabolic
pathways.
Pregnancy
entails
a
fine
maternal−fetal
interaction
to
assist
energetic
demands
fetus
where
trophoblast
cells
have
central
role.
Maternal
neutrophil
functional
shaping
has
been
proposed
though
conditioning
during
pregnancy
not
studied
yet.
Here,
we
explored
effects
trophoblast‐derived
factors
rewiring
neutrophils
from
nonpregnant
women
its
impact
functions
like
reactive
oxygen
species
(ROS)
production,
extracellular
trap
(NET)
release,
migration.
In
parallel,
immunometabolic
status
isolated
pregnant
(16−20
weeks)
was
compared
with
age‐matched
control
samples.
Trophoblast‐derived
induced
glucose
uptake
lipid
droplet
accumulation
without
activating
ROS
production
or
NET
release.
Conditioned
media
also
inhibited
PMA‐induced
NETosis
partly
impairing
neutrophils.
turn,
had
increased
basal
accumulation,
women,
accompanied
higher
release
NETs.
Interestingly,
NETs
blocked
fatty
acid
oxidation
inhibitor
indicating
contribution
activity
pregnancy.
Results
consistent
mechanisms
underlying
point
out
profiling.
These
findings
provide
novel
clues
understand
homeostasis
maintenance
raise
clinical
potential
monitoring
normal
complicated
pregnancies.
