Incidence Of Acute Kidney Injury In Mild, Moderate And Severe Cases Of Coronavirus Disease DOI Creative Commons

Mahvesh Mahmud,

Ashok Kumar,

Khurram Baqai

et al.

Journal of Rawalpindi Medical College, Journal Year: 2023, Volume and Issue: 27(4)

Published: Dec. 30, 2023

Objective: The purpose of this research was to determine the incidence Acute Kidney Injury (AKI) in COVID-19-affected patients Methods: This retrospective cohort study conducted at Ziauddin Hospital Clifton Campus from June December 2020. Adult with AKI or acute-on-chronic kidney disease (ACKD) were included a study. Patients infected SARS-CoV2 and renal involvement directed towards ICU/Nephrology departments which have expertise perform laboratory analysis, radiography institution treatment. Supplemental oxygen use documented. also assessed information about therapy (antivirals, immunomodulators, RRT) results (renal function recovery death). Results: After excluding obstructive AKI, total 180 (mean age 50.1 years) 104 males 76 females research. 120 found prerenal, 60 had intrinsic significant differences between mild, moderate, severe cases (p=0.004). injury survivors complete rate 70%, partial 22%, hemodialysis dependency 8%. Conclusion: COVID-19 infection often develop more those critical stages exhibit proteinuria dipstick hematuria. Long-term follow-up for should be done evaluate its influence on outcome, larger samples are required elucidate association damage. Keywords: Coronavirus Disease, Renal Replacement Therapy, proteinuria, hematuria

Language: Английский

Screening Targets for Diagnosis and Treatment of Cognitive Dysfunction in Stroke through Transcriptome Combined with Machine Learning DOI Open Access
Zhibin Chen, Junxiong Li,

Yangbo Hou

et al.

Journal of Bacteriology and Mycology, Journal Year: 2023, Volume and Issue: 10(3)

Published: Dec. 4, 2023

Post-Stroke Cognitive Impairment (PSCI) is one of the major complications after stroke. The evaluation PSCI usually depends on neuropsychology tests, but results these tests are subjective and inaccurate. Need to find more objective indicators as identification markers PSCI. In this study, we use machine learning biomakers PSCI, established regulatory networks at transcriptional level. Several gene such ORC1, TOMM40L SHISAL2A identified biomakers, several miRNA hsa-mir-130b-3p hsa-mir-484 interacted most tight with genes. study help better distinguish patients PS in clinical practice, identifying relevant biomarker genes miRNAs that can serve potential therapeutic sites.

Language: Английский

Citations

0
Incidence Of Acute Kidney Injury In Mild, Moderate And Severe Cases Of Coronavirus Disease DOI Creative Commons

Mahvesh Mahmud,

Ashok Kumar,

Khurram Baqai

et al.

Journal of Rawalpindi Medical College, Journal Year: 2023, Volume and Issue: 27(4)

Published: Dec. 30, 2023

Objective: The purpose of this research was to determine the incidence Acute Kidney Injury (AKI) in COVID-19-affected patients Methods: This retrospective cohort study conducted at Ziauddin Hospital Clifton Campus from June December 2020. Adult with AKI or acute-on-chronic kidney disease (ACKD) were included a study. Patients infected SARS-CoV2 and renal involvement directed towards ICU/Nephrology departments which have expertise perform laboratory analysis, radiography institution treatment. Supplemental oxygen use documented. also assessed information about therapy (antivirals, immunomodulators, RRT) results (renal function recovery death). Results: After excluding obstructive AKI, total 180 (mean age 50.1 years) 104 males 76 females research. 120 found prerenal, 60 had intrinsic significant differences between mild, moderate, severe cases (p=0.004). injury survivors complete rate 70%, partial 22%, hemodialysis dependency 8%. Conclusion: COVID-19 infection often develop more those critical stages exhibit proteinuria dipstick hematuria. Long-term follow-up for should be done evaluate its influence on outcome, larger samples are required elucidate association damage. Keywords: Coronavirus Disease, Renal Replacement Therapy, proteinuria, hematuria

Language: Английский

Citations

0