The Association and Prognostic Implications of Long Non-Coding RNAs in Major Psychiatric Disorders, Alzheimer’s Diseases and Parkinson’s Diseases: A Systematic Review DOI Open Access

Lin Zhu,

Meng Guo, Ke Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10995 - 10995

Published: Oct. 12, 2024

The prevalence of psychiatric disorders and neurodegenerative diseases is steadily increasing, placing a significant burden on both society individuals. Given the intricate multifaceted nature these diseases, precise underlying mechanisms remain elusive. Consequently, there an increasing imperative to investigate mechanisms, identify specific target sites for effective treatment, provide accurate diagnosis patients with diseases. Numerous studies have revealed alterations in expression long non-coding RNAs (lncRNAs) suggesting their potential increase probability Moreover, findings propose that lncRNAs could be used as highly valuable biomarkers diagnosing treating thereby offering novel insights future clinical interventions. review presents comprehensive summary origin, biological functions, action lncRNAs, while exploring implications pathogenesis utility biomarkers.

Language: Английский

BK Polyomavirus and acute kidney injury in transplant recipients: signaling pathways and molecular mechanisms DOI Creative Commons

Samar Bizhani,

Afsoon Afshari, Ramin Yaghobi

et al.

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 4, 2025

Acute kidney injury (AKI) is a condition that can result in changes both urine production and creatinine levels the bloodstream, complicating treatment process worsening outcomes for many hospitalized patients. BK polyomavirus (BKPyV), member of Polyomaviridae family, prevalent population remains latent body. It reactivate individuals with compromised immune system, particularly post-kidney transplant, activate various transcription factors mediators. Although reactivation often asymptomatic, it present as AKI, which risk factor early loss transplanted organ. The response to BKPyV crucial controlling virus safeguarding organs from damage during infection. Understanding pathways may offer novel opportunities effectively treating BKPyV-associated complications. This review seeks elucidate potential mechanisms by lead AKI analyzing signaling pathways, well identification molecular utilize induce AKI.

Language: Английский

Citations

0
Acute kidney injury and energy metabolism DOI
Mingkang Zhang, Yanrong Ma,

Yong-wen Jin

et al.

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 570, P. 120208 - 120208

Published: Feb. 20, 2025

Language: Английский

Citations

0
Research and Application Prospect of Nanomedicine in Kidney Disease: A Bibliometric Analysis From 2003 to 2024 DOI Creative Commons
Yilin Meng,

Lu Yan Sui,

Tianhua Xu

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3007 - 3030

Published: March 1, 2025

Abstract: Kidney disease is a major public health concern that has significant effect on patient's life span and quality of life. However, effective treatment for most kidney diseases lacking. Nanotechnology mainly explores the design, characterization, production, applications objects in nanoscale range been widely used medical field. To date, there an increasing amount research application nanotechnology disease. systematic bibliometric studies remain rare. In this review, data collected from Web Science Core Collection database until December 31, 2024, were subjected to analysis. A total 1179 articles reviews included. The publication trends, countries, institutions, authors, co-authorship, co-citations, journals, keywords, references pertaining topic examined. results showed increasing. leading country, organization, author China, Sichuan University, Professor Peng Huang, respectively. ACS APPLIED MATERIALS & INTERFACES was top journal among 464 journals which published. KIDNEY INTERNATIONAL cited increases shown "acute disease", "drug delivery", "oxidative stress", "diabetic nephropathy", "chronic indicating current hotspots. Furthermore, development prospects challenges discussed review. How achieve precise drug delivery render kidney-targeting therapy reality may be problematic future studies. Keywords: nanomedicine, disease, analysis, delivery, diagnosis,

Language: Английский

Citations

0
The Association and Prognostic Implications of Long Non-Coding RNAs in Major Psychiatric Disorders, Alzheimer’s Diseases and Parkinson’s Diseases: A Systematic Review DOI Open Access

Lin Zhu,

Meng Guo, Ke Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10995 - 10995

Published: Oct. 12, 2024

The prevalence of psychiatric disorders and neurodegenerative diseases is steadily increasing, placing a significant burden on both society individuals. Given the intricate multifaceted nature these diseases, precise underlying mechanisms remain elusive. Consequently, there an increasing imperative to investigate mechanisms, identify specific target sites for effective treatment, provide accurate diagnosis patients with diseases. Numerous studies have revealed alterations in expression long non-coding RNAs (lncRNAs) suggesting their potential increase probability Moreover, findings propose that lncRNAs could be used as highly valuable biomarkers diagnosing treating thereby offering novel insights future clinical interventions. review presents comprehensive summary origin, biological functions, action lncRNAs, while exploring implications pathogenesis utility biomarkers.

Language: Английский

Citations

0