Impact of sinus surgery on nasal discharge in chronic rhinosinusitis: A systematic review and meta‐analysis

International Forum of Allergy & Rhinology, Journal Year: 2025, Volume and Issue: 15(2), P. 174 - 184

Published: Jan. 6, 2025

ABSTRACT Background Nasal discharge is one of the cardinal symptoms chronic rhinosinusitis, impacting over 50% patients. For patients with refractory to standard medical therapy, endoscopic sinus surgery an option. The objective this study characterize how nasal improves after in rhinosinusitis. Methods literature was searched for articles reporting symptom data both at baseline and surgery. Specific interest on 22‐item sinonasal outcome test (SNOT‐22) were “need blow nose,” “runny “postnasal discharge,” “thick discharge.” SNOT‐22 scores ranged from 0 5 based upon severity. Visual analog scale equivalents recorded when available. Results A total 16 studies ( n = 7193) included analysis. All four questions saw significant improvement, need nose (‒1.8 [95% confidence interval, CI: ‒2.3, ‒1.2]) runny ‒1.9, ‒1.1]) seeing largest benefit. Patients polyps more improvement than those without polyps. difference between polyp no groups (‒1.9 vs. ‒1.0, p < 0.001) 0.0001). undergoing index or revision all symptoms. Conclusion Surgery rhinosinusitis globally, particular benefit SNOT‐22. see larger degrees compared However, also experience discharge.

Language: Английский

---

Letter to the Editor Regarding “Real‐world Predictors of Dupilumab Prescription in Patients With Chronic Rhinosinusitis With Nasal Polyps”

International Forum of Allergy & Rhinology, Journal Year: 2025, Volume and Issue: 15(2), P. 217 - 218

Published: Jan. 6, 2025

We congratulate Dorismond et al. [1] on their impactful study, " Real-world predictors of dupilumab prescription in patients with chronic rhinosinusitis nasal polyps" published the International Forum Allergy & Rhinology. The study provides valuable insights into factors influencing for polyps (CRSwNP). However, several limitations should be addressed to strengthen findings. First, a limitation is its cross-sectional design and short follow-up period, which hinder assessment long-term outcomes such as recurrence, safety, resistance. Longitudinal studies multiple data points are necessary track biomarkers symptoms over time, while also exploring resistance mechanisms like antibody production. Expanding sample size conducting multicenter would enhance robustness findings provide deeper treatment effectiveness. Secondly, CRSwNP complex immune-mediated disease involving inflammatory pathways, including Th1, Th17, epithelial barrier dysfunction [2]. While focuses Th2-driven inflammation, targeting single pathway may not offer control, particularly cases. Integrating multiomics explore interactions among these pathways investigating combination therapies other biologics or small molecules could comprehensiveness sustainability strategies. Moreover, predicting medication use surgical but lacks personalized analyses comparing surgery pharmacotherapy alone, limits clinical applicability. To address this, comprehensive efficacy evaluation model developed that incorporates patient-specific severity, biomarkers, comorbidities. This optimize decision-making between biologic therapies, thereby enhancing precision improving Additionally, heterogeneity polyp microenvironment can significantly influence responses [3]. Techniques immunohistochemistry single-cell sequencing used differences healthy tissue [4]. Studying interplay microenvironmental regulation medicine. Last, emphasizes biological effects overlooks improvements quality life. Incorporating tools SNOT-22 patient satisfaction measures more [5]. Including patient-reported core metrics better capture real-world experiences, relevance informing optimization. In conclusion, although practice, further addressing ensure broader applicability value. studies, integration, approaches will reliability authors declare they have no known competing financial interests personal relationships influenced work reported this paper. No datasets were generated analyzed during current study.

Language: Английский

---

Jieyu Guben decoction alleviates combined allergic rhinitis and asthma syndrome by balancing Th17/Treg expression and restoring PPARD

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156508 - 156508

Published: Feb. 14, 2025

Language: Английский

---

The Relationship Between Air Pollution, Meteorological Factors, and Eosinophil Counts in Peripheral Blood of Patients With Allergic Rhinitis: A Cross‐Sectional Study

Canadian Respiratory Journal, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Objective: To evaluate the relationship between air pollution, meteorological factors, and eosinophils in peripheral blood of allergic rhinitis (AR) patients. Methods: We conducted a retrospective study medical records from Ninth Medical Center PLA General Hospital Beijing. A review (1st January 2014-31th August 2022) 1080 AR patients who underwent eosinophil count tests. Patients were stratified into elevated normal groups. Daily data (mean temperature relative humidity) ambient pollutant levels (PM2.5, PM10, NO2, SO2, CO, ozone [O3]) collected. The mean factors on day measurement calculated separately for each group. Linear regression was performed to analyze association counts both among Results: In patients, 11.85% had counts. Higher (16.88 ± 9.09°C), humidity (57.75 17.22%), O3 (116.54 54.92 μg/m3) correlated significantly (p < 0.05) with confirmed positive associations (β = 0.003), 0.001), 0.0004) 0.05). Other pollutants showed no significant differences. Conclusion: Elevated higher temperature, humidity, levels. these factors.

Language: Английский

---

The clinical and pathological histology efficacy of biological therapy for severe asthma with a phenotype of type 2 inflammation - systematic review

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Asthma is a complex, chronic inflammatory condition of the airways that comes in many forms. Because different processes drive it, we can generally categorize asthma into two main types: type 2 and non-type asthma. Type inflammation usually culprit most folks grappling with severe There noticeable difference treatment approaches for phenotypes The reason patients suffering from respond well to biological agents. Several well-verified agents, such as anti-immunoglobulin E (IgE) monoclonal antibodies, anti-interleukin (IL)-4 anti-IL-5 anti-thymic stromal lymphopoietin (TSLP) have shown outstanding effectiveness. They significantly alleviate exacerbations, lower number eosinophils, improve pulmonary function, decrease dependence on oral corticosteroids, elevate quality life This discourse meticulously evaluates therapeutic prowess agents control asthma, concurrently investigating their impact histological indices, highlight crucial role precision medicine strategic concatenation therapy this refractory malady.

Language: Английский

---

Potential association between allergic disease and risk of Alzheimer’s disease: insight from genetic analysis

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

Language: Английский

---

Expression of Alpha-Smooth Muscle Actin in Nasal Polyp Tissue of Chronic Rhinosinusitis Patients With and Without Aspirin Hypersensitivity

Ear Nose & Throat Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Background: Previous research has shown that myofibroblasts in the nasal/sinus mucosa are not only structural cells but also a rich source of inflammatory mediators. Thus, they influence immune response and play an essential role pathogenesis chronic rhinosinusitis with nasal polyposis. did provide clear answer to question whether number polyps (NPs) affects extent sinus disease. This cross-sectional study investigates relationship between active myofibroblasts, eosinophil count, clinical parameters patients NPs without aspirin sensitivity. Methods: Patients diagnosed NPs, sensitivity, healthy subjects were assessed according severity their symptoms as well endoscopic radiological findings. The quantification present surgically excised polyp tissue/healthy was conducted based on expression alpha-smooth muscle actin (α-SMA) subepithelial perivascular compartments. Eosinophils counted subepithelium tissue samples from all subjects. Results: Forty-nine included: 23 NP without, 14 12 control participants. highest levels α-SMA count observed sensitivity lowest ( P < .001; .001, respectively). A strong correlation noted parameters, particularly disease evaluated radiologically endoscopically. Conclusion: Our results suggest positive quantity inflammation sinonasal region. may serve reliable marker for assessing status

Language: Английский

---

Tuo-Min-Ding-Chuan Decoction Alleviates Asthma via Spatial Regulation of Gut Microbiota and Treg Cell Promotion

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 646 - 646

Published: April 28, 2025

Objective: Tuo-Min-Ding-Chuan decoction (TMDC), a traditional Chinese prescription, has demonstrated significant clinical efficacy in treating allergic asthma. This study aimed to investigate the mechanism of TMDC asthma from perspective Treg cells and gut microbiota across distinct segments (jejunum, ileum, cecum, colon). Methods: An ovalbumin (OVA)-induced model was established mice, followed by oral administration at high, medium, low dose. Immune lung inflammation were examined assess severity. Microbial composition determined 16S rRNA sequencing. Antibiotic cocktail Lactobacillus rhamnosus GG (LGG) administrated confirm key role specific bacteria. Results: attenuated (p < 0.01) eosinophilic infiltration as well IL-4 IL-5 secretion 0.01); it also associated with an increase lung, small intestine (SI), colon 0.05). Meanwhile, restored number species Shannon index hindgut reinstated beneficial bacteria, such Allobaculum Turicibacter, which diminished asthmatic mice. Notably, significantly enriched Bifidobacterium Lactobacillus, particularly hindgut. abundance correlated 0.05) cells, IL-4, IL-5, eosinophils. Furthermore, LGG supplementation elevated decreased due antibiotic-induced depletion. Conclusion: alleviated promoting cell expansion Lactobacillus-dependent manner different segments, providing new insights into its therapeutic mechanisms.

Language: Английский

---

Quercetin inhibits ferroptosis through the SIRT1/Nrf2/HO-1 signaling pathway and alleviates asthma disease

Translational Pediatrics, Journal Year: 2024, Volume and Issue: 13(10), P. 1747 - 1759

Published: Oct. 1, 2024

Quercetin (QCT) is a bioflavonoid derived from vegetables and fruits that has anti-inflammatory anti-ferroptosis effects against various diseases. Previous studies have shown QCT modulates the production of cellular inflammatory factors in asthma models delays development chronic airway inflammation. However, regulatory mechanism QCT, traditional Chinese medicine, treatment not been elucidated. The aim present study to investigate whether can inhibit ferroptosis via SIRT1/Nrf2 pathway play therapeutic role asthma.

Language: Английский

---

Respiratory Immune System: Structure and Players

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

---