Polyphenols as Immunomodulators and Epigenetic Modulators: An Analysis of Their Role in the Treatment and Prevention of Breast Cancer DOI Open Access
Esma Eren, Joydeep Das, Trygve O. Tollefsbol

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4143 - 4143

Published: Nov. 29, 2024

Breast cancer poses a substantial health challenge for women globally. Recently, there has been notable increase in scholarly attention regarding polyphenols, primarily attributed to not only the adverse effects associated with conventional treatments but also their immune-preventive impacts. Polyphenols, nature-derived substances present vegetation, including fruits and vegetables, have received considerable various fields of science due probable wellness merits, particularly treatment hindrance cancer. This review focuses on immunomodulatory polyphenols breast cancer, emphasizing capacity influence reaction adaptive innate immune cells within tumor-associated environment. Polyphenols are implicated modulation inflammation, enhancement antioxidant defenses, promotion epigenetic modifications, support functions. Additionally, these compounds shown activity critical cells, macrophages T cells. By targeting pathways involved evasion, may augment defensive system detect eliminate tumors. The findings suggest that incorporating polyphenol-rich foods into diet could offer promising, collaborative (integrative) approach classical remedial procedures by regulating how defense mechanism interacts disease.

Language: Английский

Revolutionizing adjuvant development: harnessing AI for next-generation cancer vaccines DOI Creative Commons
Wei Zhang, Xiaoli Zheng, Paolo Coghi

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 14, 2024

With the COVID-19 pandemic, importance of vaccines has been widely recognized and led to increased research development efforts. Vaccines also play a crucial role in cancer treatment by activating immune system target destroy cells. However, enhancing efficacy remains challenge. Adjuvants, which enhance response antigens improve vaccine effectiveness, have faced limitations recent years, resulting few novel adjuvants being identified. The advancement artificial intelligence (AI) technology drug provided foundation for adjuvant screening application, leading diversification adjuvants. This article reviews significant tumor basic clinical explores use AI screen from databases. findings this review offer valuable insights new next-generation vaccines.

Language: Английский

Citations

8
Bispecific antibodies and CLEM: an analytical approach to advanced cell imaging for therapeutic strategies DOI Creative Commons

Han‐ul Kim,

Young Kwan Kim

Han-guk hyeonmigyeong hakoeji/Applied microscopy, Journal Year: 2025, Volume and Issue: 55(1)

Published: Jan. 20, 2025

Abstract The development of bispecific antibodies (BsAbs) represents a significant advancement in therapeutic antibody design, enabling the simultaneous targeting two different antigens. This dual-targeting capability enhances efficacy, particularly complex diseases like cancer, where tumor heterogeneity presents challenge for traditional treatments. By bridging distinct pathways, BsAbs can improve specificity and minimize off-target effects, making them invaluable contexts. Integrating advanced imaging techniques, Correlative Light Electron Microscopy (CLEM), offers unique opportunity to visualize dynamic interactions within cellular environments. CLEM combines strengths optical electron microscopy, allowing researchers observe real-time antibody-antigen at nanoscale resolution. synergy not only deepens our understanding BsAbs’ mechanisms action but also provides critical insights into their spatial distribution, binding kinetics, functional dynamics live cells. In this review, integration paves way targeted strategies, fostering more effective treatments that adapt complexities disease pathology.

Language: Английский

Citations

0
BUB1 Inhibition Induces Ferroptosis in Triple-Negative Breast Cancer Cell Lines DOI Creative Commons

Sushmitha Sriramulu,

Shivani Thoidingjam,

Stephen L. Brown

et al.

DNA, Journal Year: 2025, Volume and Issue: 5(1), P. 16 - 16

Published: March 12, 2025

Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype with limited effective treatments available, including targeted therapies, often leading to poor prognosis. Mitotic checkpoint kinase BUB1 frequently overexpressed in TNBC and correlates survival outcomes suggesting its potential as therapeutic target. This study explores the cytotoxicity of cells inhibition, alone or combination radiation demonstrates that ferroptosis, an iron-dependent form programmed cell death, has role. Methods: lines (SUM159, MDA-MB-231, BT-549) were treated inhibitor BAY1816032 (BUB1i) ferroptosis activator RSL3 without 4 Gy irradiation. Cell viability assays conducted assess treatment effects, qPCR analyses measured expression key markers ACSL4, GPX4, PTGS2, SLC7A11, NCOA4, IREB2, NFS1, TFRC expression, TBARS assay lipid peroxidation levels. Ferroptosis specificity was confirmed through co-treatment Ferrostatin-1 (F-1). Results: In all studied, inhibition significantly induced marked by increased ACSL4 decreased GPX4 The BUB1i further amplified these ferroptotic markers, at least additive effect, which not present radiation. Co-treatment reversed BUB1i-mediated death may involve signaling lines. Conclusions: independently induce lines, enhanced when combined activator. Further research warranted delineate molecular mechanism BUB1-mediated TNBC.

Language: Английский

Citations

0
Lipid nanoparticles-based RNA therapies for breast cancer treatment DOI Creative Commons

Luigia Serpico,

Yuewen Zhu,

Renata Faria Maia

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(10), P. 2823 - 2844

Published: June 3, 2024

Abstract Breast cancer (BC) prevails as a major burden on global healthcare, being the most prevalent form of among women. BC is complex and heterogeneous disease, current therapies, such chemotherapy radiotherapy, frequently fall short in providing effective solutions. These treatments fail to mitigate risk recurrence cause severe side effects that, turn, compromise therapeutic responses patients. Over last decade, several strategies have been proposed overcome these limitations. Among them, RNA-based technologies demonstrated their potential across various clinical applications, notably therapy. However, RNA therapies are still limited by series critical issues like off-target effect poor stability circulation. Thus, novel approaches investigated improve targeting bioavailability formulations achieve an appropriate outcome. Lipid nanoparticles (LNPs) largely proven be advantageous carrier for nucleic acids RNA. This perspective explores recent advances technology with emphasis LNPs’ utilization nanocarriers therapy progresses applications. Graphical

Language: Английский

Citations

1
Polyphenols as Immunomodulators and Epigenetic Modulators: An Analysis of Their Role in the Treatment and Prevention of Breast Cancer DOI Open Access
Esma Eren, Joydeep Das, Trygve O. Tollefsbol

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4143 - 4143

Published: Nov. 29, 2024

Breast cancer poses a substantial health challenge for women globally. Recently, there has been notable increase in scholarly attention regarding polyphenols, primarily attributed to not only the adverse effects associated with conventional treatments but also their immune-preventive impacts. Polyphenols, nature-derived substances present vegetation, including fruits and vegetables, have received considerable various fields of science due probable wellness merits, particularly treatment hindrance cancer. This review focuses on immunomodulatory polyphenols breast cancer, emphasizing capacity influence reaction adaptive innate immune cells within tumor-associated environment. Polyphenols are implicated modulation inflammation, enhancement antioxidant defenses, promotion epigenetic modifications, support functions. Additionally, these compounds shown activity critical cells, macrophages T cells. By targeting pathways involved evasion, may augment defensive system detect eliminate tumors. The findings suggest that incorporating polyphenol-rich foods into diet could offer promising, collaborative (integrative) approach classical remedial procedures by regulating how defense mechanism interacts disease.

Language: Английский

Citations

0