Potential association between COVID-19 and neurological disorders: analysis of common genes and therapeutics DOI Creative Commons
Wenzhi Chen, Shishi Jiang, Li Cheng

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 14, 2024

As the COVID-19 pandemic persists, increasing evidences suggest that patients with may face risks of neurological complications and sequelae. To address this issue, we conducted a comprehensive study aimed at exploring relationship between various disorders, particular focus on shared dysregulated genes potential therapeutic targets. We selected six disorders for investigation, including Alzheimer’s disease, epilepsy, stroke, Parkinson’s sleep disorders. Through bioinformatics analysis association these COVID-19, to uncover common molecular mechanisms treatment pathways. In study, utilized publicly available RNA-Seq microarray datasets, employed tools such as Limma DESeq2 differential gene analysis. Gene Ontology Kyoto Encyclopedia Genes Genomes pathway enrichment analysis, explored biological features Additionally, focused analyzing regulatory roles miRNA transcription factors differentially expressed genes, predicted drugs interacting genes. These analyses contribute better understanding provide theoretical basis future strategies. research, aim offer deeper insights scientific community present new perspectives clinical practice in addressing challenges sequelae faced by patients.

Language: Английский

Alcohol Consumption Modulates the Development of Chronic Pain in COVID-19 Patients: A Network Meta-Analysis DOI Creative Commons
Muhammed Bishir, Michael Vigorito,

Ming-Huan Chan

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: 8(2), P. 409 - 422

Published: Feb. 4, 2025

The mechanisms underlying the onset and progression of chronic pain in COVID-19 patients have been understudied. Using network meta-analysis, we previously demonstrated that alcohol augments symptoms pathologies possibly by inducing a severe cytokine storm. We others also reported acute consumption produces analgesic effects, while results hyperalgesia pain. This study aimed to identify influence on publicly available curated gene expression data sets differentially expressed genes (DEGs) prefrontal cortex (PFC) amygdala patients, employed bioinformatics application, QIAGEN ingenuity pathway analysis (IPA), key signaling pathways, upstream regulators, biological functions these brain areas known play role Canonical revealed activation neuropathic pathways involving storm, S100 family, IL-6, neuroinflammation. IPA's builder was construct map shared molecules between pain-related constructs (discomfort, pain, inflammatory pain). simulation inhibited this map. To COVID-19, overlaid DEGs from PFC onto networks, mimicking during SARS-CoV-2 infection. Upregulation predicted an increase as well PFC. Our suggest directly inhibits presence exaggerates impaired signaling, neuroinflammation, CNS providing novel insights into associated with patients.

Language: Английский

Citations

0
Potential association between COVID-19 and neurological disorders: analysis of common genes and therapeutics DOI Creative Commons
Wenzhi Chen, Shishi Jiang, Li Cheng

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 14, 2024

As the COVID-19 pandemic persists, increasing evidences suggest that patients with may face risks of neurological complications and sequelae. To address this issue, we conducted a comprehensive study aimed at exploring relationship between various disorders, particular focus on shared dysregulated genes potential therapeutic targets. We selected six disorders for investigation, including Alzheimer’s disease, epilepsy, stroke, Parkinson’s sleep disorders. Through bioinformatics analysis association these COVID-19, to uncover common molecular mechanisms treatment pathways. In study, utilized publicly available RNA-Seq microarray datasets, employed tools such as Limma DESeq2 differential gene analysis. Gene Ontology Kyoto Encyclopedia Genes Genomes pathway enrichment analysis, explored biological features Additionally, focused analyzing regulatory roles miRNA transcription factors differentially expressed genes, predicted drugs interacting genes. These analyses contribute better understanding provide theoretical basis future strategies. research, aim offer deeper insights scientific community present new perspectives clinical practice in addressing challenges sequelae faced by patients.

Language: Английский

Citations

1