Molecules,
Journal Year:
2024,
Volume and Issue:
29(19), P. 4533 - 4533
Published: Sept. 24, 2024
The
oral
cavity
is
a
frequent
site
for
head
and
neck
cancers,
which
rank
as
the
sixth
most
common
cancer
globally,
with
5-year
survival
rate
slightly
over
50%.
Current
treatments
are
limited,
resistance
to
therapy
remains
significant
clinical
obstacle.
IsCT1,
membrane-active
peptide
derived
from
venom
of
scorpion
Opisthacanthus
madagascariensis,
has
shown
antitumor
effects
in
various
cell
lines,
including
breast
chronic
myeloid
leukemia.
However,
its
hemolytic
action
limits
potential
therapeutic
use.
This
study
aims
assess
antiproliferative
activities
synthetic
peptides
IsCT1
(IsCT-P,
AC-AFPK-IsCT1,
AFPK-IsCT1,
AC-KKK-IsCT1,
KKK-IsCT1)
context
squamous
carcinoma.
We
evaluated
cytotoxic
these
on
tongue
carcinoma
cells
normal
cells,
well
their
impact
cycle
phases,
expression
proliferation
markers,
modulators
death
pathways,
mitochondrial
potential.
Our
results
indicate
that
derivatives
IsCT-P
AC-AFPK-IsCT1
possess
properties
towards
reducing
membrane
proliferative
index.
treatment
led
positive
modulation
pro-apoptotic
markers
p53
caspases
3
8,
decrease
PCNA
Cyclin
D1
expression,
arrest
S
phase.
Notably,
contrary
parental
peptide,
did
not
exhibit
activity
or
cytotoxicity
cells.
Therefore,
might
be
viable
option
treatment.
Critical Reviews in Microbiology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 25
Published: Feb. 18, 2025
ABSTRACTsLactoferrin
(LF)
is
a
glycoprotein,
member
of
the
transferrin
family,
and
present
in
variety
secretory
fluids,
including
milk,
saliva,
tears,
mucosal
secretions.
Iron
binding,
immunological
regulation,
antibacterial
action,
intestinal
nutrition
absorption
are
only
few
its
important
biological
roles.
Although
much
research
has
been
done
on
human
lactoferrin
(hLF),
LF
derived
from
different
animals
equally
essential
for
physiology
health.
Depending
intended
application
mechanism
goods
containing
peptide
derivatives
may
be
classified
as
medical
devices
under
FDA
rules
or
EU
Directives.
For
regulations,
product
categorized
device
if
it
primarily
provides
antimicrobial
health
advantages.
However,
LFs
not
considered
when
used
food
addition
supplement
without
particular
medicinal
claims.
Safety
efficacy
data
examined
regulatory
approval
this
category
to
guarantee
appropriate
usage
usefulness
clinical
settings.
When
utilized
various
applications,
wound
healing,
gastrointestinal
problems,
immune
system
stimulation,
complex
nature
potential
advantages
their
would
consistent
with
categorization
class
II
device.
The
role
several
species
(especially
cameloids)
discussed
paper
products
activities
where
satisfies
requirements
Separations,
Journal Year:
2025,
Volume and Issue:
12(3), P. 55 - 55
Published: Feb. 20, 2025
Rice
bean
is
a
legume
that
considered
to
be
an
important
source
of
protein;
it
still
poorly
understood
but
can
produce
peptides
with
various
biological
activities.
These
released
by
enzymes
during
gastrointestinal
passage
and
have
physiological
effect
on
cancer
cells.
Since
both
the
type
enzyme
cocktail
used
are
crucial
for
production
against
certain
cell
types,
anticancer
effects
Vigna
umbellata
isolate
hydrolysate
MDA
SiHa
cells
were
investigated
in
this
study.
The
was
obtained
via
isoelectric
precipitation,
pepsin
P7012
pancreatin
P1750.
activity
determined
viability
MTT
assay,
Pearson
correlation
coefficient
calculated
determine
relationships
between
total
phenolic
compounds,
antioxidant
isolated
rice
protein
its
hydrolysate.
had
higher
concentration
compounds
than
does,
resulting
high
activity.
inhibition
proliferation
twofold
greater
when
they
exposed
isolate,
IC50
values
at
1000
μg/mL
after
48
h
exposure
good
alternative
inhibiting
cells,
although
further
studies
needed.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 1885 - 1885
Published: Feb. 22, 2025
Gastric
cancer
(GC)
is
one
of
the
leading
causes
cancer-related
mortality
worldwide,
characterised
by
poor
prognosis
and
limited
responsiveness
to
chemotherapy.
There
a
need
for
new
more
effective
anticancer
agents.
Antimicrobial
peptides
(AMPs)
represent
promising
class
biomolecules
this
purpose.
Naturally
occurring
in
innate
immune
system,
these
can
also
exert
cytotoxic
effects
against
cells,
earning
them
designation
"anticancer
peptides"
(ACPs).
They
have
potential
be
viable
support
current
chemotherapy
schedules
due
their
selectivity
cells
minor
propensity
induce
chemoresistance
cells.
Insects
are
an
excellent
source
AMPs.
Among
them,
its
ability
thrive
hostile
microorganism-rich
environments,
we
isolated
peptide
fraction
from
Hermetia
illucens
L.
(Diptera:
Stratiomyidae)
haemolymph
evaluate
possible
activity.
We
tested
Peptide
Fractions
(PFs)
AGS
KATO
III
gastric
cell
lines.
Data
obtained
indicated
that
PFs,
especially
those
resulting
Escherichia
coli
Micrococcus
flavus
infection
(to
boost
response),
were
able
inhibit
tumour
growth
inducing
apoptosis
or
cycle
arrest
line-specific
manner.
These
results
further
investigation
into
use
antimicrobial
produced
insects
as
Research in Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
20(2), P. 165 - 187
Published: March 1, 2025
Despite
great
advances
in
cancer
identification
and
treatment,
malignancies
remain
the
primary
cause
of
high
morbidity
mortality
worldwide.
The
drawbacks
conventional
chemotherapy,
such
as
severe
toxicity,
lack
specificity
related
to
actively
dividing
cells,
resistance,
can
warrant
urgent
need
develop
an
alternative
approach
treat
this
disease.
To
overcome
drawbacks,
researchers
are
attempting
deliver
drugs
site
action
(targeted
delivery)
or
identify
that
specifically
target
tumor
cells.
In
regard,
highly
cationic
amphipathic
antimicrobial
peptides
attracting
attention
due
their
potent
anticancer
activity,
low
cost
manufacture,
and,
most
critically,
tumor-targeting
activity.
A
growing
number
documents
have
shown
some
mentioned
exhibited
a
broad
spectrum
cytotoxic
activity
against
cells
but
not
normal
mammalian
entitled
peptides.
Due
solubility,
strong
penetration,
selectivity,
ability
be
used
alone
conjunction
with
other
medications,
potential
become
very
successful
treatments
future.
This
review
provided
overview
studies
concerning
peptide
classification,
modes
action,
also
summarized
developed
for
targeting
different
types
malignancies.
role
silico
methods
artificial
intelligence
design
discovery
was
briefly
explained.
Additionally,
current
addressed
challenges
utilizing
therapy
highlighted
currently
undergoing
clinical
trials.
PubMed,
Journal Year:
2025,
Volume and Issue:
5(1), P. e1185 - e1185
Published: April 1, 2025
Marine-derived
collagen
peptides
have
been
acknowledged
for
their
therapeutic
potential,
especially
in
cancer
therapy
and
inflammation
management.
The
aim
of
this
study
was
to
investigate
the
molecular
mechanisms
that
contribute
anticancer,
anti-inflammatory
antioxidant
properties
yellowfin
tuna
(YFTCP)
utilizing
a
network
pharmacology
approach.
YFTCP
extracted
from
bones
(Thunnus
albacares)
subsequently
hydrolyzed
with
trypsin.
Seventeen
were
discovered
using
liquid
chromatography
conjunction
high-resolution
mass
spectrometry
(LC-HRMS).
A
method
utilized
interactions
between
biological
targets.
Additionally,
gene
ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
enrichment
analyses
performed
identify
pertinent
pathways
involved
antioxidant,
effects
these
peptides.
GO
analysis
revealed
key
associations
critical
cancer-
inflammation-related
genes
encoding
proteins
such
as
CCND1,
SRC,
AKT1,
IL-1β,
TNF,
PPARG,
which
exhibited
significant
interactions.
These
are
essential
regulation
cell
cycle,
development
tumors,
response
inflammatory
stimuli.
KEGG
also
number
pathways,
endocrine
resistance,
Kaposi
sarcoma-associated
herpesvirus
infection,
proteoglycans
cancer,
human
cytomegalovirus
infection.
findings
highlight
potential
use
multifaceted
agent,
indicating
role
regulating
important
associated
inflammation.
This
provides
new
valuable
insights
into
pharmacological
YFTCP,
paving
way
future
studies
drug
focused
on
bioactive
