The Complex Inflammatory and Nutritional Indices to Predict Prognostic Risk for Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

ABSTRACT Purpose To investigate the role of systemic inflammatory response index (SIRI) and high‐density lipoprotein cholesterol (HDL‐C) low‐density (LDL‐C) levels in predicting risk major adverse cardiovascular events (MACEs) patients with acute coronary syndrome (ACS) undergoing percutaneous intervention (PCI). Patients Methods Overall, 1377 ACS who underwent PCI between January 2016 December 2018 were consecutively enrolled. The divided into MACEs ( n = 60) non‐MACEs 1317) groups. study endpoints MACEs, including cardiac‐related mortality rehospitalization for severe heart failure (HF), myocardial infarction (MI), in‐stent restenosis. Results Both groups showed significant differences age > 65 years, history HF, MI, cardiogenic shock, left ventricular ejection fraction < 40%, SIRI ≥ 2.848, SIRI/HDL‐C 1.977, × LDL‐C 4.609. Kaplan–Meier curve that low group had higher cumulative survival than high group. Additionally, univariate multivariate Cox proportional hazards model demonstrated 4.609 independent factors PCI. Restricted cubic spline models generated to visualize relationship SIRI, SIRI/HDL‐C, prognostic risk. Conclusion all PCI, which may be useful markers assessment long prognosis.

Language: Английский

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Joint association of estimated glucose disposal rate and systemic inflammation response index with mortality in cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 29, 2025

The Cardiovascular-Kidney-Metabolic (CKM) syndrome underscores the complex interactions among metabolic disorders, kidney disease, and cardiovascular conditions. Insulin resistance (IR) inflammation are crucial in CKM development, but their combined effect stages 0–3 remains unclear. Using data from National Health Nutrition Examination Survey (NHANES), we included 18,295 participants with 10 cycles between 1999 2018. IR was assessed using estimated glucose disposal rate (eGDR), systemic evaluated Systemic Inflammation Response Index (SIRI). primary endpoint all-cause mortality, secondary disease (CVD) mortality. Over an average follow-up period of 121 months, recorded 1,998 deaths 539 CVD deaths. Both eGDR SIRI were independent risk factors for hazard ratios (HR) 0.90 (0.86, 0.94) mortality 0.85 (0.78, 0.93) per unit increase eGDR. For SIRI, HRs 1.16 (1.11, 1.21) 1.33 (1.19, 1.46) SIRI. Compared to individuals high low levels, those levels exhibited significantly higher risks, 1.97 (1.58, 2.44) 2.35 (1.48, 3.73) Subgroup analysis revealed that impact particularly significant patients under 60 years old. In 0–3, have joint on Combining these markers can help identify high-risk early, enabling timely monitoring intervention improve outcomes. What is currently known about this topic? key research question? new? How might study influence clinical practice?

Language: Английский

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A prospective cohort study on the joint associations of abdominal aortic calcification and systemic inflammation response index with mortality risk

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 18, 2025

Language: Английский

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Association between S100A12 and risk of peripheral arterial disease in patients with dyslipidemia: a cross-sectional study

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 24, 2025

Abstract Objective S100A12 acts as a pro-inflammatory agent in vivo, with close relationship plaque formation patients acute coronary syndrome (ACS), end-stage renal disease, and diabetes. Peripheral arterial disease (PAD) can lead to mobility difficulties ultimately disability amputation. The association between risk of peripheral remains unclear. This study aims investigate the PAD dyslipidemia. Methods From March 2023 June 2024, 478 were included this cross-sectional study. They divided into group ( n = 105) control 373) according presence or absence (The diagnosis is combination patient’s clinical symptoms, imaging evidence ankle-brachial index). Plasma was detected by available kit. General information, history, smoking laboratory indicators collected from both groups. analyzed using statistical methods. Results Levels significantly higher dyslipidemia [0.22 (0.13,1.49) ng/cL vs. 0.13 (0.10,0.18)ng/cL, p value < 0.001]. Univariate multivariate logistic regression analyses suggested that increasing levels [Odd ratio (OR) (95%CI) 2.264 (1.681, 3.047), 0.05]. In addition, lower high-density lipoprotein cholesterol (HDL-C) level diabetes mellitus (DM) independent factors for [OR 0.388 (0.186,0.809), 0.012; OR 2.375 (1.527,3.695), Subgroup analysis positively associated all subgroups, regardless whether HDL-C 1.03 mmol/L, age > 60 years, hypertension. Restricted cubic spline (RCS) curves correlation nonlinear -non-linear 0.05). RCS showed positive stronger when less than 1.00ng/cL. Conclusion conclusion, elevated an factor different after adjusting factors. There non-linear PAD, at below These findings implied potential biomarker identifying who are high developing PAD. also be routinely monitored dyslipidemic populations early detection guide management Finally, results emphasize inflammation plays important role development suggesting lipid immunomodulation may effective prevention Clinical trial number MR-35-24-038431.

Language: Английский

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Association Between Systemic Inflammation Response Index and Slow Coronary Flow Phenomenon in Patients with Ischemia and No Obstructive Coronary Arteries

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 4045 - 4053

Published: Sept. 1, 2024

Inflammation plays a key role in the pathogenesis of slow coronary flow phenomenon (SCFP). SCFP is condition that can complicate management ischemia and no obstructive arteries (INOCA), making it essential to identify reliable predictors. Although systemic inflammation response index (SIRI) has been proven relate various cardiovascular diseases. However, predictive value SIRI for patients with INOCA remains unclear.

Language: Английский

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Prognostic value of remnant-like particle cholesterol in ischemic heart failure patients following percutaneous coronary intervention

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Feb. 3, 2025

The relationship between remnant-like particle cholesterol (RLP-C) and cardiovascular disease risk prognosis has been established, but its effect on the of ischemic heart failure (IHF) patients undergoing percutaneous coronary intervention (PCI) remains uncertain. In this study, 2036 with IHF who underwent PCI were included. Patients categorized into tertiles based their RLP-C levels. primary outcome was major adverse events (MACE). Kaplan-Meier survival analysis used to assess incidence MACE other outcomes. Multivariate Cox regression models employed investigate correlation studied nonlinear examined through restricted cubic spline (RCS). Subgroup analyses performed interactions assessed. study results showed a clear association higher levels an increased in participants. This validated by analyses. multivariate demonstrated independent factor for MACE, whether assessed as continuous variable[hazard ratio (HR), 95% confidence interval (CI): 1.50, 1.15-1.98, p = 0.003] or tertiles[HR, CI: 2.57, 2.03-3.26, < 0.001, tertile 3 vs 1]. A observed, indicating that levels(Nonlinear 0.001). remained consistent across various subgroups, no significant found. There positive PCI.

Language: Английский

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Calpain inhibition as a novel therapeutic strategy for aortic dissection with acute lower extremity ischemia

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: April 21, 2025

Language: Английский

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Analysis of the Associations of Measurements of Body Composition and Inflammatory Factors with Cardiovascular Disease and Its Comorbidities in a Community-Based Study

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1066 - 1066

Published: May 11, 2024

The associations of cardiovascular disease (CVD) with comorbidities and biochemical body composition measurements are repeatedly described but have not been studied simultaneously. In the present cross-sectional study, information on CVD [type 2 diabetes mellitus (T2DM), hypertension (HTN), hyperlipidemia (HDL)], composition, levels soluble markers, other measures were collected from 1079 individuals. When we examined association each comorbidity CVD, controlling for comorbidities, observed a clear pattern comorbidity-related specific tested covariates. For example, T2DM was significantly associated GDF-15 leptin/adiponectin (L/A) ratio independently two comorbidities; HTN, similarly, extracellular water (ECW) levels, L/A ratio, age; HDL related to age only. showed very strong independent being most strongly HTN (OR = 10.89, 6.46–18.38) also (2.49, 1.43–4.33) (1.93, 1.12–3.33). An additive Bayesian network analysis suggests that all three particularly ECW content, likely main role in risk development. Other factors, lymphocyte count, systemic inflammation response index, indirectly acting through ECW.

Language: Английский

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Lipoprotein(a) as a novel biomarker for predicting adverse outcomes in ischemic heart failure

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 5, 2024

Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD). However, the association between Lp(a) and adverse outcomes in patients with ischemic heart failure (IHF) remains unclear. This study aimed to investigate relationship serum levels incidence of major events (MACE) IHF patients.

Language: Английский

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Integration of the systemic inflammatory response index with pulse pressure enhances prognostication of cardiovascular mortality in the general population of the United States: insights from the NHANES database

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 18, 2024

Background The prognostic significance of utilizing both the systemic inflammatory response index (SIRI) and pulse pressure (PP) collectively in assessing cardiovascular mortality (CVM) across populations remains to be elucidated. Methods Multivariate Cox proportional hazards analysis investigated SIRI, PP, CVM association. Receiver operating characteristic (ROC) curves evaluated predictive performance combined SIRI PP for broader demographic. Subsequently, area under ROC curve (AUC) was compared using Z -test, a novel nomogram developed assess its accuracy predicting CVM. Restricted cubic spline (RCS) used evaluate association between PP. Results study involved 19,086 NHANES database individuals, with 9,531 males (49.94%). During follow-up period, 456 instances (2.39%) occurred. revealed [adjusted hazard ratio (HR) 1.16, P &lt; 0.001] (HR = 1.01, 0.004) as independent predictors. A 0.1-unit increase 10 mmHg escalation correlated 2% (adjusted HR 1.02, 0.001) 7% 1.07, enhancements, respectively. 0.77, ranging from 0.77 0.79 female cohorts, non-smokers, non-pathological contexts. High either high or were associated 3 2 times risk low Adding general factors improved efficacy (Z 4.17, 0.001). nomogram's concordance 0.90, indicating excellent discrimination. predicted probabilities’ calibration plot aligned actual rates at 1, 5, years. RCS showed an S-shaped relationship Conclusions Integrating demonstrates substantial within United States community, notably

Language: Английский

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