Gut Microbiota’s role in lipoma development: evidence from mendelian randomization DOI Creative Commons
Yuxin Li, Jiahao Chen, Hang Yao

et al.

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 15, 2024

Background Lipoma, a benign tumor derived from mesenchymal tissue, significantly affects patients’ physical and psychological wellbeing. Increasing evidence points to strong link between the gut microbiome (GM) lipoma incidence. This study utilizes Mendelian Randomization (MR) assess potential causal relationships GM development. Methods We conducted two-sample MR analysis using genome-wide association (GWAS) data MiBioGen FinnGen explore relationship lipoma. The dataset included 18,340 participants with 14,587 single nucleotide polymorphisms (SNPs), while comprised 412,181 21,306,349 SNPs. employed 5 methods: Inverse Variance Weighted (IVW), Median, Simple Mode, MR-Egger, Mode. Additional assessments Cochran’s Q test for result heterogeneity, PRESSO horizontal pleiotropy, sensitivity analyses through scatter plots, leave-one-out analyses, funnel forest plots. Results IVW method identified 18 gene predictors trans-genus associated risk. Protective effects against (BL) were observed in Eubacterium rectale group, Desulfovibrio, Ruminococcus1, Clostridium sensu stricto1, Lachnospiraceae UCG001; conversely, UCG008 was linked increased BL Desulfovibrio provided protection TS-BL; however, Family XIII AD3011 coprostanoligenes NK4A136 Parasutterella an TS-BL innocuum Anaerotruncus, Ruminiclostridium6, UCG001 offered LS-BL, LS-BL brachy Odoribacter, Butyricimonas, Subdoligranulum, stricto1 protective HFNS-BL; Ruminococcaceae UCG005 HFNS-BL Conclusion Compared malignant tumors, research on lipomas has been relatively limited. study, analysis, new of specific development lipomas. Certain bacterial species may act as or harmful factors formation, offering avenues future treatment strategies. However, additional is required unravel complexity how influences pathogenesis

Language: Английский

A combination treatment with a water extract from Euglena gracilis and anti-PD-1 antibody strongly inhibits growth of lung cancer in mice through stimulating tumor-infiltrating lymphocytes DOI
Susumu Ishiguro,

Sarah DeVader,

C. C. F. Blake

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113953 - 113953

Published: Jan. 13, 2025

Language: Английский

Citations

0
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota DOI Creative Commons
Yanbo Liu, Ying Zhou, Haoyue Zhang

et al.

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

Citations

0
Role of gut microbiome in suppression of cancers DOI Creative Commons
Yao Xu, Zhaoyu Gao, Jiaying Liu

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 20, 2025

The pathogenesis of cancer is closely related to the disruption homeostasis in human body. gut microbiome plays crucial roles maintaining its host throughout lifespan. In recent years, a large number studies have shown that dysbiosis involved entire process initiation, development, and prognosis by influencing immune system metabolism. Some specific intestinal bacteria promote occurrence development cancers under certain conditions. Conversely, some other suppress oncogenesis progression cancers, including inhibiting delaying boosting therapeutic effect on cancers. promoting effects been comprehensively discussed previous review. This article will review latest advances mechanisms suppression, providing new perspective for developing strategies prevention treatment.

Language: Английский

Citations

0
The metabolic dialogue between intratumoural microbes and cancer: implications for immunotherapy DOI

Y. Situ,

Pengpeng Zhang, Cangang Zhang

et al.

EBioMedicine, Journal Year: 2025, Volume and Issue: 115, P. 105708 - 105708

Published: April 22, 2025

Language: Английский

Citations

0
The human microbiome: redefining cancer pathogenesis and therapy DOI Creative Commons
Yogita K. Adlakha, Ravindresh Chhabra

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 28, 2025

Language: Английский

Citations

0
Identification of hsa-miR-193a-5p-SURF4 axis related to the gut microbiota-metabolites- cytokines in lung cancer based on Mendelian randomization study and bioinformatics analysis DOI Creative Commons

Jie Yu,

Sibo Meng, Tiantian Xuan

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 27, 2024

Language: Английский

Citations

1
Combination of lipopolysaccharide and polygalacturonic acid exerts antitumor activity and augments anti-PD-L1 immunotherapy DOI
Jie Song, Jiaxin Li, Anping Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136390 - 136390

Published: Oct. 9, 2024

Language: Английский

Citations

0
Gut Microbiota’s role in lipoma development: evidence from mendelian randomization DOI Creative Commons
Yuxin Li, Jiahao Chen, Hang Yao

et al.

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 15, 2024

Background Lipoma, a benign tumor derived from mesenchymal tissue, significantly affects patients’ physical and psychological wellbeing. Increasing evidence points to strong link between the gut microbiome (GM) lipoma incidence. This study utilizes Mendelian Randomization (MR) assess potential causal relationships GM development. Methods We conducted two-sample MR analysis using genome-wide association (GWAS) data MiBioGen FinnGen explore relationship lipoma. The dataset included 18,340 participants with 14,587 single nucleotide polymorphisms (SNPs), while comprised 412,181 21,306,349 SNPs. employed 5 methods: Inverse Variance Weighted (IVW), Median, Simple Mode, MR-Egger, Mode. Additional assessments Cochran’s Q test for result heterogeneity, PRESSO horizontal pleiotropy, sensitivity analyses through scatter plots, leave-one-out analyses, funnel forest plots. Results IVW method identified 18 gene predictors trans-genus associated risk. Protective effects against (BL) were observed in Eubacterium rectale group, Desulfovibrio, Ruminococcus1, Clostridium sensu stricto1, Lachnospiraceae UCG001; conversely, UCG008 was linked increased BL Desulfovibrio provided protection TS-BL; however, Family XIII AD3011 coprostanoligenes NK4A136 Parasutterella an TS-BL innocuum Anaerotruncus, Ruminiclostridium6, UCG001 offered LS-BL, LS-BL brachy Odoribacter, Butyricimonas, Subdoligranulum, stricto1 protective HFNS-BL; Ruminococcaceae UCG005 HFNS-BL Conclusion Compared malignant tumors, research on lipomas has been relatively limited. study, analysis, new of specific development lipomas. Certain bacterial species may act as or harmful factors formation, offering avenues future treatment strategies. However, additional is required unravel complexity how influences pathogenesis

Language: Английский

Citations

0