Journal of the Peripheral Nervous System,
Journal Year:
2025,
Volume and Issue:
30(1)
Published: March 1, 2025
Immune-mediated
sensory
neuronopathies
(SNN)
can
occur
alongside
autoimmune
disorders
(e.g.,
Sjögren
syndrome),
involve
autoantibodies
(such
as
anti-FGFR3
or
anti-AGO
antibodies),
present
in
isolation.
The
underlying
mechanisms
remain
unclear.
This
study
aimed
to
investigate
the
role
of
proinflammatory
cytokines
these
conditions.
Blood
levels
IL-1β,
IL-6,
IL-17,
TNF-α,
INF
α-2,
and
INF-γ
were
measured
using
a
Bioplex
T200
platform
Bio-Plex
Pro
Reagent
Kit
III
113
patients
with
SNN
between
2.4
464.4
months
after
symptom
onset,
categorized
based
on
disease
course
(acute,
subacute,
chronic).
Eighteen
had
antibodies,
48
14
an
without
detectable
FGFR3
antibodies.
Disease
extent
was
by
score,
while
severity
evaluated
modified
Rankin
score.
Immunoreactivity
against
IL-6
via
ELISA.
Multicomponent
analysis
utilizing
identified
four
distinct
patient
subgroups
characterized
differences
age
at
onset
No
significant
observed
among
regarding
severity,
presence
association
disease.
A
small
subgroup
three
younger
exhibited
highest
IL-1β.
Another
seven
displayed
elevated
α-2
tended
towards
scores.
largest
group
(95
subjects)
comprised
older
individuals
relatively
lower
cytokine
decreased
anti-IL-6
immunoreactivity.
These
profiles
suggest
diverse
within
immune-mediated
SNN.
Further
investigation
is
warranted
determine
whether
certain
profiles,
particularly
those
involving
young
cytokines,
might
benefit
from
targeted
treatments.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(3), P. 404 - 404
Published: March 12, 2025
Aging
is
a
complex,
progressive,
and
irreversible
biological
process
that
entails
numerous
structural
functional
changes
in
the
organism.
These
affect
all
bodily
systems,
reducing
their
ability
to
respond
adapt
environment.
Chronic
inflammation
one
of
key
factors
driving
development
age-related
diseases,
ultimately
causing
substantial
decline
abilities
older
individuals.
This
persistent
inflammatory
state
(commonly
known
as
“inflammaging”)
characterized
by
elevated
levels
pro-inflammatory
cytokines,
an
increase
oxidative
stress,
perturbation
immune
homeostasis.
Several
factors,
including
cellular
senescence,
contribute
this
milieu,
thereby
amplifying
conditions
such
cardiovascular
disease,
neurodegeneration,
metabolic
disorders.
Exploring
mechanisms
chronic
aging
essential
for
developing
targeted
interventions
aimed
at
promoting
healthy
aging.
review
explains
strong
connection
between
inflammation,
highlighting
potential
therapeutic
approaches
like
pharmacological
treatments,
dietary
strategies,
lifestyle
changes.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(3), P. 721 - 721
Published: March 15, 2025
Background/Objectives:
Immunosenescence
implies
innate
and
adaptive
immunity
dysfunction,
which
naturally
occurs
with
aging.
It
is
a
complex
multifactorial
process
can
be
triggered
by
either
genetic
changes,
immune
changes
or
both.
Numerous
research
studies
have
shown
that
the
of
senescence
goes
alongside
chronic
activation.
The
purpose
this
study
to
analyze
in
expression
genes
associated
responses
order
identify
reliable
biomarkers
for
Methods:
For
aim,
55
clinically
healthy
individuals
active
age
(21–65
years)
were
distributed
based
on
immunophenotyping
two
groups,
without
signs
premature
senescence.
A
gene
analysis
was
subsequently
made
those
differentially
expressed
presented
interpreted.
Results:
Altogether,
forty-eight
(48)
exhibited
differential
between
most
showed
up-regulation
(45)
(fold
change
more
than
2),
only
three
down-regulated
less
−2).
highest
positive
fold
IL-1β
(10.76),
BCL6
(13.25)
CCL4
(15.91),
while
negative
documented
IL23R
(−3.10),
IL5
(−2.66)
PTGS2
(COX-2)
(−2.15).
Conclusions:
Our
results
reveal
immunosenescence
positively
inflammation,
typical
aging
process.
On
other
hand,
we
identified
markers
possible
protective
effects
against
oxidative
stress
tumorigenesis.
These
findings
aid
early
diagnosis
degenerative
diseases
subclinical
phase,
as
well
development
strategies
prevent
processes
Pathogens,
Journal Year:
2025,
Volume and Issue:
14(4), P. 346 - 346
Published: April 3, 2025
SARS-CoV-2,
first
identified
in
December
2019,
caused
a
global
pandemic,
resulting
over
6.8
million
deaths
by
March
2023.
The
elderly,
or
individuals
65,
accounted
for
the
majority
of
COVID-19
deaths,
with
81%
fatalities
US
2020
occurring
this
group.
Beyond
mortality,
aging
populations
are
also
at
higher
risk
long-term
cardiovascular
complications
and
acute
respiratory
distress
syndrome
(ARDS).
Although
these
outcomes
may
be
influenced
comorbidities
common
age
has
been
found
to
standalone
factor
severe
infection.
Therefore,
investigating
age-related
factors
is
crucial
protecting
vulnerable
Of
particular
interest
cytokine
storm
phenomenon,
an
excessive
inflammatory
response
that
contributes
symptoms,
including
ARDS
damage.
Elevated
levels
multiple
cytokines
cases
COVID-19.
We
propose
changes
occur
profiles
as
we
contribute
aberrant
responses.
This
review
specifically
explored
interleukin
class
IL-1,
IL-6,
IL-17,
IL-23
considered
potential
biologics
targeting
alleviate
both
individuals.
Journal of Medicinal Food,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 21, 2025
Inflammation
is
a
crucial
response
to
harmful
stimuli,
but
its
chronic
activation
contributes
various
diseases,
including
inflammatory
bowel
disease,
osteoarthritis,
and
neurological
disorders.
While
nonsteroidal
anti-inflammatory
drugs
are
widely
used
as
anti-inflammation
drugs,
their
extended
usage
often
results
in
severe
side
effects,
emphasizing
the
need
for
safer
alternatives.
Therefore,
it
of
greatest
importance
identify
discover
new
agents
that
exhibit
reduced
incidence
adverse
effects.
This
study
investigates
potential
methanol
extracts
from
eight
native
Vietnamese
plant
species.
These
were
screened
ability
inhibit
nitric
oxide
production
pro-inflammatory
cytokine
expression
lipopolysaccharides-stimulated
RAW264.7
macrophages.
Among
tested
extracts,
those
derived
Huberantha
luensis
(Pierre)
Chaowasku
Ancistrocladus
tectorius
(Lour.)
Merr.
demonstrated
notable
reductions
NO,
TNF-α,
interleukin
(IL)-1β,
IL-6
levels.
Further
analysis
revealed
these
abundant
polyphenols
flavonoids,
compounds
recognized
Furthermore,
exerted
effects
by
inhibiting
kappa-light-chain-enhancer
activated
B
cells
mitogen-activated
protein
kinase
signaling
pathways,
evidenced
phosphorylation
proteins.
suggest
obtained
H.
A.
possess
considerable
paving
way
towards
innovative
development
therapeutic
approaches
aimed
at
alleviating
inflammation.
