Critical Care,
Journal Year:
2024,
Volume and Issue:
28(1)
Published: Dec. 12, 2024
Cardiopulmonary
bypass
(CPB)
triggers
marked
cytokine
release
often
followed
by
a
systemic
inflammatory
response
syndrome,
associated
with
adverse
postoperative
outcomes.
This
trial
investigates
the
intraoperative
use
of
haemoadsorption
(HA)
during
cardiac
surgery
CPB
to
assess
its
impact
on
response.
In
this
prospective
randomised
controlled
(ethics
approval
no.
5094-14DRKS00007928),
patients
(>
65
years)
undergoing
elective
on-pump
were
HA
(CytoSorb)
or
standard
care
without
HA.
Primary
outcome
was
difference
in
mean
interleukin
(IL)-6
serum
concentrations
between
groups
intensive
unit
(ICU)
admission.
The
secondary
outcomes
included
various
clinical
and
biochemical
endpoints.
Statistical
methods
paired
unpaired
t-tests,
Wilcoxon,
Mann–Whitney
U-tests,
chi-square
tests.
Thirty-eight
allocated
receive
either
(n
=
19)
19).
primary
outcome,
IL-6
levels
ICU
admission,
did
not
differ
study
group
controls
(214.4
±
328.8
vs.
155.8
159.6
pg/ml,
p
0.511).
During
pre-
versus
post-adsorber
IL-2,
IL-6,
IL-8,
IL-10,
heparan
sulfate
myoglobin
post-
reduced.
Furthermore,
day
1
2
ICU.
While
sequential
organ
failure
assessment
scores,
lactate
levels,
C-reactive
protein
procalcitonin
(PCT)
showed
no
statistically
significant
differences.
Regarding
haemodynamic
stability
treatment
index
(3.2
0.7
2.47
0.47
l/min/m2,
0.012)
increased,
lower
fluid
requirements
as
well
decreased
fibrinogen
requirement
observed.
Need
for
renal
replacement
therapy
though
shorter
duration
observed
group.
Time
ventilator,
respiratory
parameters,
infectious
complications,
delirium
hospital
lengths
stay,
mortality
groups.
reduce
level
admission
afterwards.
Even
reduced
load
There
differences
course
other
concentrations,
dysfunction,
stay
rates.
Trial
registration
prospectively
DRKS00007928
published
under:
Baumann
A,
Buchwald
D,
Annecke
T,
Hellmich
M,
Zahn
PK,
Hohn
A.
RECCAS
-
REmoval
Cytokines
Cardiac
Surgery:
protocol
trial.
Trials.
2016;17:
137.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(11)
Published: Oct. 28, 2024
Abstract
Tumor
immunotherapy
has
significantly
transformed
the
field
of
oncology
over
past
decade.
An
optimal
tumor
would
ideally
elicit
robust
innate
and
adaptive
immune
responses
within
microenvironment
(TIME).
Unfortunately,
system
experiences
functional
decline
with
chronological
age,
a
process
termed
“immunosenescence,”
which
contributes
to
impaired
against
pathogens,
suboptimal
vaccination
outcomes,
heightened
vulnerability
various
diseases,
including
cancer.
In
this
context,
we
will
elucidate
hallmarks
molecular
mechanisms
underlying
immunosenescence,
detailing
alterations
in
immunosenescence
at
molecular,
cellular,
organ,
disease
levels.
The
role
tumorigenesis
senescence‐related
extracellular
matrix
(ECM)
also
been
addressed.
Recognizing
that
is
dynamic
influenced
by
factors,
evaluate
treatment
strategies
targeting
mechanisms,
as
well
methods
for
cell,
organ
restoration,
present
emerging
approaches
immunotherapy.
overarching
goal
research
prevent
development,
recurrence,
metastasis,
ultimately
improving
patient
prognosis.
Our
review
aims
reveal
latest
advancements
prospective
directions
research,
offering
theoretical
basis
development
practical
anti‐immunosenescence
anti‐tumor
strategies.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1716 - 1716
Published: Aug. 1, 2024
The
term
'inflammaging'
has
been
coined
to
describe
the
chronic
state
of
inflammation
derived
from
ongoing
cycles
tissue
damage
and
subsequent
immune
responses.
This
inflammatory
status
contributes
decline
organs
physiological
functions,
accelerates
aging
process,
increases
risk
age-related
illnesses
death.
During
aging,
gut
microbiota
(GM)
undergoes
significant
changes,
including
a
decreased
diversity
species,
in
beneficial
bacteria,
rise
proinflammatory
ones,
resulting
persistent
low-grade
inflammation.
Moreover,
environmental
factors,
such
as
diet
medications,
contribute
changes
GM
function,
preventing
or
promoting
inflammaging.
narrative
review
aims
clarify
underlying
mechanisms
inflammaging
specifically
investigate
influence
several
factors
on
these
mechanisms,
while
also
exploring
potential
differences
related
sex.
lifestyle
pharmacological
interventions
will
be
suggested
promote
healthy
aging.
