Effectiveness of Probiotics and Standard Therapy Versus Standard Therapy Alone in Patients of Mild to Moderate Rheumatoid Arthritis DOI Creative Commons
Gulnaz Iqbal,

Tazeen Nazar,

Bilal Aziz

et al.

Pakistan Journal of Health Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 189 - 193

Published: Dec. 31, 2024

Analgesics, steroids and disease modifying anti-rheumatic drugs (DMARDs) are the cornerstone of treatment in rheumatoid arthritis (RA). Objective: To determine effectiveness probiotics, introduced to standard treatment, improving Disease Activity Score 28 (DAS-28) patients with mild moderate arthritis, when given for a period three months. Methods: This randomized controlled trial registered under ClinicalTrials.gov ID: NCT06594822, was conducted on diagnosed cases presenting Mayo hospital, Lahore from 24th August 2023 till 23rd February 2024. Eighty-eight were recruited employing simple random sampling techniques categorized into two groups. Group A received therapy along probiotics whereas B alone. DAS-28 score assessed at baseline, 45 90 days. Results: Patients showed an effective reduction 22.7% compared 6.8% group (p=0.035). baseline 3.67 ± 0.61 vs 3.63 0.52, p=0.708, after days 3.15 0.63 3.49 0.56, p=0.010 2.93 0.75 3.27 p=0.015. During 90, greater decrease i.e., -0.52 -0.14 p<0.010 -0.74 0.36 p<0.015 than patients. also had significant improvement mean (p<0.05). Conclusion: Daily supplementation is alleviation symptoms severity having arthritis.

Language: Английский

Gut microbiota and their metabolites in the immune response of rheumatoid arthritis: Therapeutic potential and future directions DOI
Xiaoyu Cai,

Fujia Ren,

Yao Yao

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114034 - 114034

Published: Jan. 12, 2025

Language: Английский

Citations

1
Gut microbiota mediated T cells regulation and autoimmune diseases DOI Creative Commons
Nabeel Khalid Bhutta, Xiaolin Xu,

Cuiqin Jian

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 19, 2024

Gut microbiota regulates the immune system, development and progression of autoimmune diseases (AIDs) overall health. Recent studies have played a crucial part in understanding specific role different gut bacterial strains their metabolites AIDs. Microbial signatures AIDs are revealed by advanced sequencing metabolomics studies. Microbes such as Faecalibacterium prausnitzii, Akkermansia muciniphila, Anaerostipes caccae, Bacteroides sp. , Roseburia Blautia faecis Clostridium lavalense Christensenellaceae Coprococcus Firmicutes Ruminococcaceae Lachnospiraceae Megamonas sp., Monoglobus Streptococcus pneumoniae Bifidobacterium help maintain homeostasis; whereas, Prevotella copri, Ruminococcus gnavus, Lactobacillus salivarius, Enterococcus gallinarum, Elizabeth menigoseptica, Collinsella Escherichia Fusobacterium Enterobacter ludwigii, Enterobacteriaceae Proteobacteria Porphyromonas gingivalis nigrescens Dorea cause immuno-pathogenesis. A complex web interactions is influence on cells various T cell subsets CD4+ cells, CD8+ natural killer γδ etc. Certain AIDs, including rheumatoid arthritis, diabetes mellitus, atopic asthma, inflammatory bowel disease non-alcoholic fatty liver exhibit state dysbiosis, characterized alterations microbial diversity relative abundance taxa. This review summarizes recent developments certain composition factors affecting regulatory through also focuses potential application therapeutic significance microbiota-based interventions novel adjunctive therapies for Further research to determine precise association each strain required.

Language: Английский

Citations

5
MICROBIOTA INTESTINAL E DOENÇAS AUTOIMUNE: UMA REVISÃO INTEGRATIVA DOI Creative Commons

Gabrielly de Oliveira Feliz,

Cristiane da Silva Marciano Grasselli

Revista Contemporânea, Journal Year: 2025, Volume and Issue: 5(2), P. e7526 - e7526

Published: Feb. 20, 2025

Introdução: A microbiota intestinal é o conjunto de micro-organismos que colonizam intestino humano. É composta por vírus, bactérias, fungos, parasitas fazem parte uma rede interações com hospedeiro As funções da incluem proteção contra patógenos, inibição citocinas pró-inflamatórias e imunomodulação. O desequilíbrio também possui efeitos na fisiologia do hospedeiro, inclusive imunidade, estudos apontam a prevalência disbiose em portadores doenças autoimunes. Objetivo: realizar revisão integrativa para identificar relação Metodologia: Foi realizada integrativa. Para busca bibliográfica, foram utilizados os descritores “intestinal microbiota”, microbiome” “autoimmune diseases” sendo empregado qualificador “treatment” “modulation”. levantamento dos artigos foi realizado nas bases dados Literatura Latino-Americana Caribe Ciências Saúde (LILACS), Scientific Eletronic Library Online (SciELO), PubMed Science Direct. pesquisa conduzida base pergunta norteadora “Qual entre as autoimunes?” Resultados discussão: aplicação critérios inclusão resultaram seleção 28 artigos. Todos publicados língua inglesa anos 2014 2024. Conclusão: Os achados dessa sugerem pode desencadear autoimunidade, tendo como desfecho autoimunes, possivelmente meio mimetismo molecular. Da mesma forma, sugere-se uso probióticos ter potencial terapêutico no tratamento modulação sintomatologia

Citations

0
Effects of nutritional supplements and dietary interventions on rheumatoid arthritis: An umbrella review of meta-analyses of randomized controlled trials DOI

Xueer Cheng,

Xiao Hu, Jian Tang

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(6), P. 103792 - 103792

Published: March 6, 2025

Language: Английский

Citations

0
Persea americana Peel: A Promising Source of Nutraceutical for the Mitigation of Cardiovascular Risk in Arthritic Rats Through the Gut–Joint Axis DOI Creative Commons
Doha A. Mohamed, Asmaa Ramadan, Hoda B. Mabrok

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 590 - 590

Published: April 16, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by the inflammation of synovial fluid. The incidence cardiovascular diseases (CVDs) increasing in RA patients. This research first report to investigate anti-arthritic effect avocado peel nutraceutical (APN) and its potential mitigating risk associated with RA. antioxidant activity phytochemical composition APN were assessed. interaction APN's active compounds protein tyrosine phosphatase non-receptor type 22 (PTPN22) was studied using molecular docking. impact on plasma lipid profile, oxidative markers, indices coronary atherogenicity as CVD markers evaluated. gene expression COX-2, IL-6, IL-1β, IL-10, TNF-α liver spleen tissues measured. rat gut microbiota profile investigated 16S rRNA amplicon sequencing. exhibited high activity, low thrombogenicity indices, ratio hypocholesterolemic hypercholesterolemic fatty acids indicating cardioprotective potential. administration led reduction stress dyslipidemia, markers. downregulated genes, while IL-10 significantly upregulated spleen. Treatment favorable restoring eubiosis modulating RA-associated bacterial taxa linked impaired immune function cardiometabolic diseases. In docking, β-amyrin ellagic acid showed highest binding affinity for PTPN22. may represent promising approach ameliorating present results will be offering foundation future in-depth nutraceuticals from agriculture by-products. Additionally, they supporting public health policies aimed at preventing controlling rheumatoid arthritis.

Language: Английский

Citations

0
Linking microbial communities to rheumatoid arthritis: focus on gut, oral microbiome and their extracellular vesicles DOI Creative Commons

Jian Lü,

Yi Wang,

Jing Wu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Rheumatoid arthritis (RA) is a severe, chronic autoimmune disease affecting approximately 1% of the global population. Research has demonstrated that microorganisms play crucial role in onset and progression RA. This indicates disruption immune homeostasis may originate from mucosal sites, such as gut oral cavity. In intestines patients preclinical stage RA, an increased abundance Prevotella species with strong association to was observed. cavity, infections by Porphyromonas gingivalis Aggregatibacter actinomycetemcomitans can mediate production anti-citrullinated protein antibodies (ACPAs), potentially contributing RA pathogenesis. Nevertheless, no single bacterial been consistently identified primary driver review will discuss connection between bacteria development arthritis. Additionally, it explores extracellular vesicles (bEVs) inducing inflammation their potential pathogenic roles

Language: Английский

Citations

0
Nature of the Association between Rheumatoid Arthritis and Cervical Cancer and Its Potential Therapeutic Implications DOI Open Access

Kirill Gusakov,

Alexander Kalinkovich, Shai Ashkenazi

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2569 - 2569

Published: Aug. 5, 2024

It is now established that patients with rheumatoid arthritis (RA) have an increased risk of developing cervical cancer (CC) or its precursor, intraepithelial neoplasia (CIN). However, the underlying mechanisms this association not been elucidated. RA characterized by unresolved chronic inflammation. suggested human papillomavirus (HPV) infection in exacerbates inflammation, increasing CC. The tumor microenvironment CC also marked which aggravates manifestations both conditions. Gut and vaginal dysbiosis are considered potential contribute to inflammation aggravation manifestations. Numerous clinical pre-clinical studies demonstrated beneficial effects various nutritional approaches attenuate including polyunsaturated fatty acids their derivatives, specialized pro-resolving mediators (SPMs), probiotics, prebiotics, certain diets. We believe successful resolution correction dysbiosis, combination current anti-RA anti-CC therapies, a promising therapeutic approach for This could reduce development HPV-infected patients.

Language: Английский

Citations

3
Phase IV Metabolism DOI

Deniz Coskuner,

Aadra P. Bhatt

Gastroenterology Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Citations

0
Exploring the Role of the Microbiome in Rheumatoid Arthritis—A Critical Review DOI Creative Commons

Plamena Ermencheva,

Georgi Kotov, Russka Shumnalieva

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1387 - 1387

Published: July 9, 2024

Rheumatoid arthritis (RA) is a chronic, autoimmune rheumatic disease characterized by synovial joint inflammation with subsequent destruction as well systemic manifestation, leading to impaired mobility and quality of life. The etiopathogenesis RA still unknown, genetic, epigenetic environmental factors (incl. tobacco smoking) contributing susceptibility. link between genetic like "shared epitope alleles" the development known. However, why only some carriers have break in self-tolerance develop autoimmunity needs be clarified. presence autoantibodies patients' serum months years prior onset clinical manifestations has moved focus possible factors, including triggers that could contribute initiation perpetuation inflammatory reaction RA. Over past several years, role microorganisms at mucosal sites (i.e., microbiome) emerged an essential mediator An increasing number studies revealed microbial immunopathogenesis diseases. Interaction host immune system microbiota initiates loss immunological tolerance autoimmunity. alteration microbiome composition, so-called dysbiosis, associated Immune dysfunction caused dysbiosis sustains chronic inflammation. This review aims provide critical summary literature findings related hypothesis reciprocal relation system. Available data from reveal pivotal pathogenesis.

Language: Английский

Citations

2
Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis Therapy DOI Creative Commons
Vitaly Chasov,

Elvina Gilyazova,

Irina Ganeeva

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1653 - 1653

Published: Dec. 23, 2024

Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to joint inflammation, progressive tissue damage and significant disability, severely impacting patients’ quality of life. While the exact mechanisms underlying RA remain elusive, growing evidence suggests strong link between intestinal microbiota dysbiosis disease’s development progression. Differences in microbial composition healthy individuals patients point role gut modulating immune responses promoting inflammation. Therapies targeting restoration have demonstrated promise improving treatment efficacy, enhancing patient outcomes slowing However, complex interplay pathways requires further investigation establish causative relationships mechanisms. Here, we review current understanding microbiota’s pathogenesis its potential as therapeutic target.

Language: Английский

Citations

2