Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4143 - 4143
Published: Nov. 29, 2024
Breast
cancer
poses
a
substantial
health
challenge
for
women
globally.
Recently,
there
has
been
notable
increase
in
scholarly
attention
regarding
polyphenols,
primarily
attributed
to
not
only
the
adverse
effects
associated
with
conventional
treatments
but
also
their
immune-preventive
impacts.
Polyphenols,
nature-derived
substances
present
vegetation,
including
fruits
and
vegetables,
have
received
considerable
various
fields
of
science
due
probable
wellness
merits,
particularly
treatment
hindrance
cancer.
This
review
focuses
on
immunomodulatory
polyphenols
breast
cancer,
emphasizing
capacity
influence
reaction
adaptive
innate
immune
cells
within
tumor-associated
environment.
Polyphenols
are
implicated
modulation
inflammation,
enhancement
antioxidant
defenses,
promotion
epigenetic
modifications,
support
functions.
Additionally,
these
compounds
shown
activity
critical
cells,
macrophages
T
cells.
By
targeting
pathways
involved
evasion,
may
augment
defensive
system
detect
eliminate
tumors.
The
findings
suggest
that
incorporating
polyphenol-rich
foods
into
diet
could
offer
promising,
collaborative
(integrative)
approach
classical
remedial
procedures
by
regulating
how
defense
mechanism
interacts
disease.
Military Medical Research,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Dec. 18, 2024
Abstract
Cancer
is
a
global
health
problem
and
one
of
the
leading
causes
mortality.
Immune
checkpoint
inhibitors
have
revolutionized
field
oncology,
emerging
as
powerful
treatment
strategy.
A
key
pathway
that
has
garnered
considerable
attention
programmed
cell
death-1
(PD-1)/programmed
death
ligand-1
(PD-L1).
The
interaction
between
PD-L1
expressed
on
tumor
cells
PD-1
reduces
innate
immune
response
thus
compromises
capability
body’s
system.
Furthermore,
it
controls
phenotype
functionality
adaptive
components.
range
monoclonal
antibodies,
including
avelumab,
atezolizumab,
camrelizumab,
dostarlimab,
durvalumab,
sinitilimab,
toripalimab,
zimberelimab,
been
developed
for
targeting
PD-L1.
These
agents
can
induce
broad
spectrum
autoimmune-like
complications
may
affect
any
organ
Recent
studies
focused
effect
various
natural
compounds
inhibit
checkpoints.
This
could
contribute
to
existing
arsenal
anticancer
drugs.
Several
bioactive
shown
PD-1/PD-L1
signaling
axis,
promoting
apoptosis,
influencing
proliferation,
eventually
inhibiting
cancer
progression.
However,
there
substantial
knowledge
gap
regarding
role
different
in
context
cancer.
Hence,
this
review
aims
provide
common
connection
blockade
effects
distinct
molecules.
Moreover,
primary
focus
will
be
underlying
mechanism
action
well
clinical
efficacy
Current
challenges
along
with
scope
future
research
directions
interactions
through
substances
are
also
discussed.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(9), P. 1121 - 1121
Published: Aug. 24, 2024
Researchers
have
performed
numerous
studies
on
immunotherapy
because
of
the
high
death
rate
associated
with
gastric
cancer
(GC).
GC
research
has
made
tremendous
progress,
and
we
wanted
to
provide
an
update
this
topic.
On
basis
update,
suggest
performing
a
new
medical
evaluation
before
initiating
in
patients
increase
success
immunotherapies.
We
propose
that
start
immunotherapy,
they
should
be
evaluated
given
score
one
two
points
for
following
factors:
immunopathological
features,
molecular
genomic
potential
consequences
bacterial
pathogens,
immunotherapeutic
resistance
hyperprogressive
illness,
use
biomarkers
gauge
their
prognosis
responses
optimize
surgery.
The
proposed
scoring
system
could
also
help
diagnosis
GC.
With
all
advances
genetics,
immunology,
microbiology,
improved,
not
changed.
Currently,
diagnosed
undergo
surgical
resection
as
only
permanent
solution.
Patients
who
meet
maximum
from
presented
proposal
eligible
immediately
after
immunotherapy.
Therefore,
first-line
option
clinicians.
Nutrition and Cancer,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 17
Published: Sept. 19, 2024
Cancer
cells-derived
extracellular
vesicles
can
trigger
the
transformation
of
adipose-derived
mesenchymal
stem
cells
(ADMSC)
into
a
pro-inflammatory,
cancer-associated
adipocyte
(CAA)
phenotype.
Such
secretome-mediated
crosstalk
between
adipose
tissue
and
tumor
microenvironment
(TME)
therefore
impacts
progression
metastatic
processes.
In
addition,
emerging
roles
diet-derived
phytochemicals,
especially
epigallocatechin-3-gallate
(EGCG)
among
other
polyphenols,
in
modulating
exosome-mediated
metabolic
inflammatory
signaling
pathways
have
been
highlighted.
Here,
we
discuss
how
selected
phytochemicals
could
alter
secretome
signature
as
well
dynamics
TME,
with
focus
on
breast
cancer.
Their
broader
implication
chemoprevention
obesity-related
cancers
is
also
discussed.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4143 - 4143
Published: Nov. 29, 2024
Breast
cancer
poses
a
substantial
health
challenge
for
women
globally.
Recently,
there
has
been
notable
increase
in
scholarly
attention
regarding
polyphenols,
primarily
attributed
to
not
only
the
adverse
effects
associated
with
conventional
treatments
but
also
their
immune-preventive
impacts.
Polyphenols,
nature-derived
substances
present
vegetation,
including
fruits
and
vegetables,
have
received
considerable
various
fields
of
science
due
probable
wellness
merits,
particularly
treatment
hindrance
cancer.
This
review
focuses
on
immunomodulatory
polyphenols
breast
cancer,
emphasizing
capacity
influence
reaction
adaptive
innate
immune
cells
within
tumor-associated
environment.
Polyphenols
are
implicated
modulation
inflammation,
enhancement
antioxidant
defenses,
promotion
epigenetic
modifications,
support
functions.
Additionally,
these
compounds
shown
activity
critical
cells,
macrophages
T
cells.
By
targeting
pathways
involved
evasion,
may
augment
defensive
system
detect
eliminate
tumors.
The
findings
suggest
that
incorporating
polyphenol-rich
foods
into
diet
could
offer
promising,
collaborative
(integrative)
approach
classical
remedial
procedures
by
regulating
how
defense
mechanism
interacts
disease.
