History of Breast Cancer in Patients with Oral Lichen Planus: A Case–Control Study DOI Open Access
María García-Pola,

Lucía Rodríguez-Fonseca,

Claudia Llorente-Álvarez

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7208 - 7208

Published: Nov. 27, 2024

Objectives: The purpose of this study was to determine the association between oral lichen planus (OLP) and history cancer outside cavity predominance its location. Methods: This case–control included 600 OLP patients control subjects evaluated in same section, matched for age sex patients. were diagnosed clinically histologically. Initially, prevalence most frequent types cancers described. A Pearson chi-squared test model used OLP. It considered statistically significant whether p value ≤0.05. final multivariate regression built after applying a backward selection method complete considering odds ratio (OR) with 95% confidence interval (CI). Results: significantly associated regardless age, sex, tobacco or alcohol use both univariate [OR = 2.26 (95%CI: 1.26–4.24); 0.008] analyses 2.21 1.21–4.19); 0.012]. According location cancer, there an breast 3.71 (95%CI 1.03–13.38); 0.032]. Conclusions: suggests higher frequency particularly among compared group. Due study’s design sample limitations, these findings should be interpreted cautiously. Future longitudinal, multi-institutional studies rigorous other confounding factors are essential further explore cancer.

Language: Английский

The dual role of diabetes on oral potentially malignant disorders DOI Creative Commons
Xin Chen,

Zheng Cheng,

Junyu Xu

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: March 24, 2025

Observational studies suggest a link between diabetes and oral potentially malignant disorders (OPMDs), such as lichen planus (OLP) leukoplakia (OLK). The causal relationship, well the type of that promotes OPMDs development, remains unclear. This Mendelian randomization (MR) study estimated effects diabetes-related traits on OPMDs. Large-scale genome-wide association data 1 (T1D), 2 (T2D), fasting glucose (FG), insulin (FI), glycated hemoglobin (HbA1c), OLP, OLK, actinic cheilitis (AC) were used. Causal assessed using inverse-variance weighted (IVW), median, MR–Egger methods. Multivariable MR analyses evaluated independent roles these traits, with extensive sensitivity analyses. Genetic susceptibility to T1D (IVW OR = 1.09, 95% CI 1.02–1.17, P 0.007) T2D 0.91, 0.86–0.97, 0.002) showed protective against AC. was associated an increased risk OLP 0.007). effect AC remained robust after adjusting for FI, FG, HbA1c, while T2D's not significant when considering glycemic traits. No potential pleiotropy detected (P > 0.05). may have role in development emphasizing need routine examinations patients. Conversely, genetically predicted are significantly reduced AC, challenging previous assumptions offering new insights into relationship Further investigations required address limitations this clarify associations.

Language: Английский

Citations

0
Causal effects of circulating inflammatory proteins on oral phenotypes: Deciphering immune-mediated profiles in the host-oral axis DOI
Xinjian Ye, Chen Tan, Jianhua Cheng

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113642 - 113642

Published: Nov. 22, 2024

Language: Английский

Citations

3
Genetic Causal Relationship Between Alanine Aminotransferase Levels and Risk of Gestational Diabetes Mellitus: Mendelian Randomization Analysis Based on Two Samples DOI
Lihua Yin, Yifang Hu, Xiaoxia Hu

et al.

Twin Research and Human Genetics, Journal Year: 2024, Volume and Issue: 27(2), P. 80 - 84

Published: April 1, 2024

Gestational diabetes mellitus (GDM) is a frequent complication of pregnancy. The specific mechanisms underlying GDM have not yet been fully elucidated. Contemporary research indicates potential association between liver enzyme irregularities and an increased risk metabolic disorders, including diabetes. alanine aminotransferase (ALT) level recognized as sensitive marker injury. An increase in ALT levels hypothesized to be linked the pathogenesis insulin resistance Nonetheless, definitive causal link still needs determined. This investigation utilized two-sample Mendelian randomization (MR) examine genetic causation GDM. We acquired (ALT)-related GWAS summary data from UK Biobank, Million Veteran Program, Rotterdam Study, Lifeline Study. were obtained FinnGen Consortium. employed various MR analysis techniques, inverse-variance weighted (IVW), Egger, median, simple, weighting. In addition MR-Egger intercepts, Cochrane's Q test was also used assess heterogeneity data, MR-PRESSO horizontal pleiotropy. To association's sensitivity, leave-one-out approach employed. IVW results confirmed independent factor for development, indicated by (

Language: Английский

Citations

0
Exploring the Role of Inflammatory Cytokines in Cervical cancer Pathogenesis: Evidence from Mendelian Randomization Analysis DOI Creative Commons
Yuqiang Zhang,

D.Y. Luo,

Xinguang Chen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Background: Cervical cancer (CC) is a prevalent malignancy worldwide, which seriously threatens women's quality of life and health. Although CC etiology remains uncertain, mounting evidence suggests that inflammatory cytokines (CKs) contribute to pathogenesis. Nonetheless, more research required determine if there causal connection between them. Therefore, our study performed Mendelian randomized (MR) investigate the link CKs CC. Methods: The CK data are derived from two European population databases: one containing 41 other 91 CKs. came UK Biobank (n ≤ 408961), including 1659 cases 381902 controls ancestry. Our employed inverse variance weighted, MR-Egger, weighted median, mode analyze relation Additionally, multiple sensitivity analyses, MRE intercept test, MR-PRESSO Leave One Out, were deployed further validate robustness results. Eventually, reverse MR analysis was carried out. RESULTS: results showed increase Monokine triggered by gamma interferon )INF-γ( level negatively correlated with (odds ratio (OR) = 0.84, 95% confidence interval (95% CI): 0.72–0.99, P 0.044). Elevated cystatin D (CysD), Interleukin-8 (IL-8), Leukemia Inhibitory Factor (LIF), Monocyte chemoattractant protein 2 (MCP-2) levels positively occurrence (OR 1.18, CI:1.02–1.36, 0.025; OR 1.41, CI:1.02–1.95, 0.035; 1.39, CI:1.00–1.94, 0.044; 1.76, CI:1.25–2.47, 9×10–4), aligned analyses Reverse Results had no effect on 132 Conclusion: Herein, demonstrated potential INF-γ, CysD, IL-8, LIF, MCP-2 risk. role in development needs investigation.

Language: Английский

Citations

0
History of Breast Cancer in Patients with Oral Lichen Planus: A Case–Control Study DOI Open Access
María García-Pola,

Lucía Rodríguez-Fonseca,

Claudia Llorente-Álvarez

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7208 - 7208

Published: Nov. 27, 2024

Objectives: The purpose of this study was to determine the association between oral lichen planus (OLP) and history cancer outside cavity predominance its location. Methods: This case–control included 600 OLP patients control subjects evaluated in same section, matched for age sex patients. were diagnosed clinically histologically. Initially, prevalence most frequent types cancers described. A Pearson chi-squared test model used OLP. It considered statistically significant whether p value ≤0.05. final multivariate regression built after applying a backward selection method complete considering odds ratio (OR) with 95% confidence interval (CI). Results: significantly associated regardless age, sex, tobacco or alcohol use both univariate [OR = 2.26 (95%CI: 1.26–4.24); 0.008] analyses 2.21 1.21–4.19); 0.012]. According location cancer, there an breast 3.71 (95%CI 1.03–13.38); 0.032]. Conclusions: suggests higher frequency particularly among compared group. Due study’s design sample limitations, these findings should be interpreted cautiously. Future longitudinal, multi-institutional studies rigorous other confounding factors are essential further explore cancer.

Language: Английский

Citations

0