ImmunoTargets and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 14, P. 227 - 246
Published: March 1, 2025
Patients
with
osteoporosis
experience
increased
fracture
risk
and
decreased
quality
of
life,
which
pose
significant
health
burdens
financial
challenges.
Despite
established
links
between
immune
cell
phenotypes
inflammatory
cytokines
osteoporosis,
the
exact
mechanism
involved
remains
unclear,
further
understanding
is
needed
for
effective
prevention
treatment.
Here,
we
performed
a
two-sample
Mendelian
randomization
(MR)
study
to
estimate
causal
effects
731
types,
91
41
factors
(which
may
have
some
overlap),
5
types
osteoporosis.
In
subsequent
mediation
MR
analysis,
assessed
whether
these
mediate
relationship
Additionally,
colo-
calization
analysis
was
using
Bayesian
colocalization.
Single-cell
transcriptomic
datasets
from
patients
available
in
Gene
Expression
Omnibus
(GEO)
database.
Subsequently,
single-cell
sequencing
performed,
including
dimensionality
reduction,
clustering,
pathway
enrichment,
investigate
underlying
mechanisms.
Finally,
confirm
critical
role
IgD⁺CD24⁺
B
cells
IL-17C
vivo
dexamethasone-induced
model.
Micro-CT
used
assess
effectiveness
model
establishment.
Flow
cytometry
determine
proportion
within
lymphocytes
blood.
ELISA
Western
blotting
were
measure
levels
serum
bone
tissue.
Immunohistochemistry
conducted
evaluate
expression
This
found
that
32
38
significantly
associated
Mediation
indicated
IgD+
CD24+
exacerbated
by
influencing
interleukin-17C
(IL-17C).
The
mediated
effect
0.07837,
accounting
15.5%
total
effect.
transcriptome
supported
play
key
musculoskeletal-related
pathways
patients.
demonstrated
involvement
disease
Inflammatory
crucial
pathogenesis
immunity-related
particular,
%lymphocyte
increase
modulating
interleukin-17C.
Our
results
provide
evidence
support
link
immunity
offer
new
therapeutic
strategies
targeting
immune-mediated
Cytokines and inflammation,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
Nivolumab,
like
other
immune
checkpoint
inhibitors,
is
effective
in
treating
malignant
neoplasms.
However,
immune-mediated
adverse
events
linked
to
cytokine
imbalance
are
increasingly
reported.
These
include
myocarditis,
pericarditis,
pulmonitis,
myositis,
and
lesions
of
the
joints,
intestines,
thyroid,
often
presenting
spontaneously
with
reactive
courses.
Such
phenomena
hypothesized
stem
from
system
disinhibition
autoimmune
inflammation
involving
patient's
healthy
tissues
due
cross-sensitivity
context
imbalance.
Case
description.
A
65-year-old
woman
was
observed
for
4
years,
starting
2019,
when
she
presented
bleeding
pigmented
growths
on
her
right
shin.
This
later
diagnosed
as
nodular
melanoma
ulceration
mitotic
activity.
The
patient
under
observation
two
but
2021,
after
disease
progression,
underwent
seven
cycles
nivolumab
therapy.
Soon
after,
condition
deteriorated,
by
2022,
had
developed
acute
hematological
syndrome,
skin
hardening,
polyneuropathy.
She
admitted
rheumatology
department.
Blood
plasma
analysis
revealed
elevated
levels
interleukin-1β,
MIG,
PDGF-AB/BB,
RANTES,
TGFα.
markers
indicated
an
intermediate
inflammatory
response—less
controlled
than
patients
without
not
severe
seen
rheumatoid
arthritis.
Clinical
outcome.
findings
suggested
a
hybrid
process
systemic
cancer-related
component
Th17
overactivation,
predominance
pro-inflammatory
mediators
typical
diseases.
Nivolumab
discontinued,
comprehensive
treatment
plan
implemented
manage
cardiac,
neurological,
rheumatic
complications.
achieved
remission
melanoma.
Life,
Journal Year:
2025,
Volume and Issue:
15(5), P. 684 - 684
Published: April 23, 2025
(1)
Background:
Vitiligo
is
an
autoimmune
skin
disorder
characterized
by
melanocyte
destruction.
Despite
metabolic
disturbances
and
oxidative
stress
also
playing
a
key
role
in
its
pathogenesis,
accumulating
evidence
highlights
prominent
for
cytokine
dysregulation.
(2)
Methods:
A
systematic
search
was
conducted
to
identify
meta-analyses
published
the
last
decade
that
investigated
involvement
vitiligo.
(3)
Results:
Based
on
predefined
inclusion
criteria,
nine
were
retrieved
reviewed.
The
findings
confirm
central
interferon-gamma
(IFN-γ)
vitiligo
although
recent
suggest
IFN-γ
gene
polymorphisms
are
more
broadly
associated
with
autoimmunity
rather
than
being
vitiligo-specific.
Elevated
interleukin-17
(IL-17)
levels
have
been
consistently
reported
patients,
supporting
contribution
immune-mediated
Regulatory
T
cell
dysfunction
appears
play
crucial
disease
progression.
Additionally,
TNF-α-308
G/A
polymorphism
has
linked
genetic
susceptibility
vitiligo,
particularly
specific
populations,
reinforcing
of
TNF-α
immune
Lastly,
chemokines
involved
recruitment
melanocytes
further
illustrate
complex
inflammatory
network
underlying
disease.
(4)
Conclusions:
This
review
consolidates
from
meta-analyses,
underscoring
significance
dysregulation
highlighting
potential
therapeutic
targets.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 9, 2024
Evidence
from
observational
studies
indicates
that
inflammatory
proteins
play
a
vital
role
in
Guillain-Barre
Syndrome
(GBS).
Nevertheless,
it
is
unclear
how
circulating
are
causally
associated
with
GBS.
Herein,
we
conducted
two-sample
Mendelian
randomization
(MR)
analysis
to
systematically
explore
the
causal
links
of
genetically
determined
systemic
on
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 24, 2024
AbstractBackground:
Dyslipidemia
has
been
implicated
in
the
pathogenesis
of
several
diseases,
including
thyroid
dysfunction
and
immune
disorders.
However,
whether
circulating
lipids
long-term
use
lipid-lowering
drugs
influence
development
autoimmune
disease
(AITD)
remains
unclear.
Methods:
Two-sample
two-step
Mendelian
randomization
(MR)
studies
were
performed
to
assess
causal
relationships
between
(LDL-C,
TC,
TG,
ApoB)
seven
drug
targets
(ApoB,
CETP,
HMGCR,
LDLR,
NPC1L1,
PCSK9,PPARα)
with
AITD.
Mediation
analyses
conducted
explore
potential
mediating
factors.
Results:
There
was
no
clear
causality
(ApoB,
LDL-C,
TG)
AITD
(p
>
0.05).
ApoB
inhibition
is
related
a
reduced
risk
thyroiditis
(AT)
(OR
=
0.462,
p=
0.046),
while
PCSK9
Graves'
(GD)
0.
551,
p
=
0.033).
Moreover,
0.735,
p
0.003),
LDLR
0.779,
0.027),
NPC1L1
0.599,
0.016)
hypothyroidism
(AIH).
analysis
showed
that
exerted
effects
on
AIH
through
IL-4
FGF-19
levels.
And
effect
PCSK9inhibition
GD
TNF-β
Conclusions:
Lipid-lowering
target
gene
inhibitors
by
modulating
inflammatory
Science Insights,
Journal Year:
2024,
Volume and Issue:
44(6), P. 1409 - 1414
Published: June 29, 2024
Autoimmune
thyroid
disorders,
including
Hashimoto’s
thyroiditis
and
Grave’s
disease,
represent
complex
conditions
characterized
by
dysregulation
of
the
immune
system
targeting
gland.
Understanding
molecular
immunological
mechanisms
underlying
transition
from
to
disease
is
essential
for
unraveling
pathophysiology
these
interconnected
autoimmune
conditions.
We
propose
insights
into
intricate
interplay
genetic
factors,
responses,
hormonal
pathways
that
drive
progression
hypothyroidism
hyperthyroidism,
shedding
light
on
new
perspectives
diagnosis,
management,
future
research
directions
in
disorders.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 10, 2024
Hematological
indicators
in
the
early
stage
of
PD-1
inhibitor
treatment
may
show
superior
predictive
ability
occurrence
immune
related
adverse
event
(irAE)
compared
to
pre-treatment
indicators,
as
response
is
modulated
during
treatment.
The
objective
this
study
was
investigate
capabilities
biomarkers
for
thyroid
dysfunction
(irTD),
and
explore
potential
cytokines.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 22, 2024
AbstractBackground:
Cervical
cancer
(CC)
is
a
prevalent
malignancy
worldwide,
which
seriously
threatens
women's
quality
of
life
and
health.
Although
CC
etiology
remains
uncertain,
mounting
evidence
suggests
that
inflammatory
cytokines
(CKs)
contribute
to
pathogenesis.
Nonetheless,
more
research
required
determine
if
there
causal
connection
between
them.
Therefore,
our
study
performed
Mendelian
randomized
(MR)
investigate
the
link
CKs
CC.
Methods:
The
CK
data
are
derived
from
two
European
population
databases:
one
containing
41
other
91
CKs.
came
UK
Biobank
(n
≤
408961),
including
1659
cases
381902
controls
ancestry.
Our
employed
inverse
variance
weighted,
MR-Egger,
weighted
median,
mode
analyze
relation
Additionally,
multiple
sensitivity
analyses,
MRE
intercept
test,
MR-PRESSO
Leave
One
Out,
were
deployed
further
validate
robustness
results.
Eventually,
reverse
MR
analysis
was
carried
out.
RESULTS:
results
showed
increase
Monokine
triggered
by
gamma
interferon
)INF-γ(
level
negatively
correlated
with
(odds
ratio
(OR)
=
0.84,
95%
confidence
interval
(95%
CI):
0.72–0.99,
P
0.044).
Elevated
cystatin
D
(CysD),
Interleukin-8
(IL-8),
Leukemia
Inhibitory
Factor
(LIF),
Monocyte
chemoattractant
protein
2
(MCP-2)
levels
positively
occurrence
(OR
1.18,
CI:1.02–1.36,
0.025;
OR
1.41,
CI:1.02–1.95,
0.035;
1.39,
CI:1.00–1.94,
0.044;
1.76,
CI:1.25–2.47,
9×10–4),
aligned
analyses
Reverse
Results
had
no
effect
on
132
Conclusion:
Herein,
demonstrated
potential
INF-γ,
CysD,
IL-8,
LIF,
MCP-2
risk.
role
in
development
needs
investigation.
ImmunoTargets and Therapy,
Journal Year:
2024,
Volume and Issue:
Volume 13, P. 631 - 641
Published: Nov. 1, 2024
Dyslipidemia
has
been
implicated
in
the
pathogenesis
of
several
diseases,
including
thyroid
dysfunction
and
immune
disorders.
However,
whether
circulating
lipids
long-term
use
lipid-lowering
drugs
influence
development
autoimmune
disease
(AITD)
remains
unclear.
This
study
aims
to
evaluate
effects
on
AITD
explore
their
potential
mechanisms.
