Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 155(3), P. 800 - 802
Published: Sept. 12, 2024
Language: Английский
Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 22, 2025
Abstract Arachidonate 15-lipoxygenase type B (ALOX15B) peroxidises polyunsaturated fatty acids to their corresponding acid hydroperoxides, which are subsequently reduced into hydroxy-fatty acids. A dysregulated abundance of these biological lipid mediators has been reported in the skin and blood psoriatic compared healthy individuals. RNAscope immunohistochemistry revealed increased ALOX15B expression lesional psoriasis samples. Using a cytokine cocktail containing IL-17A, interferon-gamma tumour necrosis factor-alpha produce psoriasis-like phenotype, role for human epidermal keratinocyte inflammation was investigated. siRNA-mediated silencing CCL2 secretion. In addition CCL2, secretion CCL5 CXCL10 were elevated equivalents treated with lipoxygenase inhibitor ML351. Inhibition JAK1/STAT1 pathway reversed enhanced found silencing. Previous studies have linked growth factor receptor (EGFR) inhibition upregulation cytokines including CXCL10. EGFR signalling potentiated effect on expression. Confirming previous findings, gene cholesterol biosynthesis genes via ERK phosphorylation. Reduced phosphorylation dependant NRF2 activation. Furthermore, plasma membrane lipids investigated confocal microscopy, revealing rafts. This study suggests through modulation peroxidation EGFR/JAK1/STAT1 axis.
Language: Английский
Citations
1
Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: 300(7), P. 107442 - 107442
Published: June 3, 2024
Language: Английский
Citations
4
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217623 - 217623
Published: March 1, 2025
Mitochondrial malfunction is traditionally viewed as a major factor in tumor growth and malignancy, while recent studies have introduced conflicting views suggesting the necessity of functional mitochondria for growth. Despite these differing perspectives, specific role cutaneous squamous cell carcinoma (cSCC) remains poorly understood. In this study, we observed increased mitochondrial abundance function during development cSCC. We also identified retinoic acid receptor response 1 (RARRES1), which dramatically decreased human cSCC samples, key regulator homeostasis. Mechanistically, RARRES1 can translocate into facilitate degradation TFAM by binding to LONP1, thereby regulating biogenesis. While suppression unleashed promote biogenesis, leading progression Targeting RARRES1-LONP1/TFAM axis shows significant potential inhibiting development. This study reveals unique network homeostasis emphasizes crucial development, positioning promising therapeutic target future clinical applications.
Language: Английский
Citations
0
Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16
Published: March 18, 2025
Psoriasis is closely associated with metabolic health. The Cardiometabolic Index (CMI) an innovative and easily obtainable metric employed to assess cardiometabolic This study aims examine the possible relationship between CMI psoriasis. Data from four successive cycles of National Health Nutrition Examination Survey (NHANES) conducted 2003-2004 2009-2014 were employed. encompassed adults self-reported psoriasis diagnoses comprehensive information necessary for calculating CMI. calculation formula Triglycerides (TG)/High-density lipoprotein cholesterol (HDL-C) × WHtR (WHtR = waist circumference/height). A multivariable logistic regression model was utilized linear Subgroup analyses investigate potential contributing factors. further established using smooth curve fitting. study, utilizing NHANES data, comprised a cohort 7,327 American adults. analysis indicated that in fully adjusted model, people greatest had 71% increased probability relative those lowest (OR 1.71; 95% CI, 1.11-2.61, P < 0.05). Smooth fitting demonstrated connection (P subgroup revealed no significant interactions specific subgroups (all > Our research indicates substantial correlation method facilitates identification groups at risk psoriasis, therefore guiding therapeutic solutions public health activities improve dermatological outcomes.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 3, 2025
Background Distant metastasis of colorectal cancer (CRC) significantly impacts patient prognosis. Cuproptosis is a new form copper ion-dependent cell death. However, whether cuproptosis-related genes (CRGs) play role in the metastatic potential CRC remains unclear. This study focuses on CRGs-ACAD8 to explore its and mechanism (mCRC). Methods Clinical sample data from TCGA, GEO, Fujian Provincial Hospital patients were integrated analyze ACAD8 expression association with diagnosis prognosis CRC. Small interfering RNA, immunohistochemistry, colony formation, wound-healing assays so used evaluate biological functions ACAD8. Bioinformatics was applied investigate relationships immune infiltration, chemotherapy sensitivity, signaling pathways. Results reduced mCRC demonstrated excellent diagnostic performance. Patients high had better survival. closely associated enhanced sensitivity. Pathway enrichment analysis suggested that might inhibit by regulating pathways such as response metal ions tight junction organization. Finally, experiments confirmed positive correlation between levels mRNA expression, CuCl 2 upregulating expression. Knockdown induced cuproptosis. inhibited proliferation, stemness, migratory abilities cells, while si attenuated these effects. Moreover, sensitivity cells oxaliplatin 5-fluorouracil, whereas diminished this chemosensitizing effect. Conclusion As novel tumor suppressor, low holds prognostic value may contribute precise treatment infiltration
Language: Английский
Citations
0
Seminars in Immunology, Journal Year: 2025, Volume and Issue: 78, P. 101958 - 101958
Published: April 22, 2025
Language: Английский
Citations
0
Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)
Published: April 27, 2025
Abstract Sebaceous glands synthesize and secrete sebum, a mélange of lipids other cellular products that safeguards the mammalian integument. Differentiating sebocytes delaminate from basal membrane dislodge towards gland’s middle, where they eventually undergo poorly understood death mode in which whole cell becomes secretion product (holocrine secretion). Supported by recent transcriptomics data, this review examines idea peripheral have remarkable ability to draw nutrients blood become committed unrestrainedly invest all available resources into synthetic processes for accomplishing sebum synthesis, thereby exploiting core metabolic fluxes as glycogen turnover, glutamine-directed anaplerosis, pentose phosphate pathway de novo lipogenesis. Finally, we propose metabolic-driven are an important mechanistic component holocrine secretion. A deeper understanding these adaptations could indicate novel strategies modulating key pathogenic factor acne skin diseases.
Language: Английский
Citations
0
Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)
Published: May 14, 2025
Language: Английский
Citations
0
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Sept. 23, 2024
Language: Английский
Citations
2
Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 155(3), P. 800 - 802
Published: Sept. 12, 2024
Language: Английский
Citations
0