Tuberculosis, Journal Year: 2024, Volume and Issue: 149, P. 102577 - 102577
Published: Nov. 13, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 13, 2025
Background Subjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis, tuberculosis infection (TBI), have a high probability of progressing to disease (TB). We aim characterize the impact IMID on immune response M. (Mtb) in patients TBI and TB disease. Methods enrolled without IMID. Peripheral blood mononuclear cells (PBMCs) were stimulated Mtb-derived epitopes (MTB300). By flow-cytometry, we identified Mtb-specific CD4 + T cytokine-producing or CD25 CD134 cells. Memory activation status assessed by evaluating: CD153, HLA-DR, CD45RA, CD27. Mycobacterial growth inhibition assay (MGIA) was used evaluate ability PBMCs inhibit mycobacteria growth. A long-term stimulation detect memory response. Results The therapy did not affect magnitude Mtb-antigen number responders. TBI-IMID showed cytokine profile like patients. Mtb characterized an effector central phenotype groups. This allowed increased IFN-γ production after 6 days MTB300-stimulation. HLA-DR expression associated TB, whereas CD153 status. Finally, had MGIA Conclusion condition does key aspects Mtb, response, profile, contain replication. immunological characterization fragile population is fundamental understanding correlation between protection
Language: Английский
Citations
1
Metabolomics, Journal Year: 2024, Volume and Issue: 20(4)
Published: July 16, 2024
Amid the global health crisis, HIV/TB co-infection presents significant challenges, amplifying burden on patients and healthcare systems alike. Metabolomics offers an innovative window into metabolic disruptions caused by co-infection, potentially improving diagnosis treatment monitoring.
Language: Английский
Citations
1
Genes, Journal Year: 2024, Volume and Issue: 15(4), P. 434 - 434
Published: March 29, 2024
Tuberculosis (TB) remains a significant global health concern, necessitating accurate diagnosis and treatment monitoring. Extracellular vesicles (EVs), including exosomes, play crucial roles in disease progression, with their associated genes serving as potential biomarkers therapeutic targets. Leveraging publicly available RNA-Seq datasets of TB patients healthy controls (HCs), to identify differentially expressed (DEGs) protein-protein interaction networks immune cell profiles, the common EV-related DEGs were identified validated GSE42830 GSE40553 datasets. We have nine (SERPINA1, TNFAIP6, MAPK14, STAT1, ITGA2B, VAMP5, CTSL, CEACAM1, PLAUR) upregulated patients. Immune infiltration analysis revealed differences between HCs, highlighting increased proportions various cells These are involved cellular processes pathways related exocytosis response regulation. Notably, VAMP5 exhibited excellent diagnostic performance (AUC-0.993, sensitivity-93.8%, specificity-100%), novel biomarker for TB. The can serve that distinguish HCs. which functions exosome biogenesis showed upregulation TB, be targeted interventions outcomes.
Language: Английский
Citations
0
Thorax, Journal Year: 2024, Volume and Issue: 79(9), P. 799 - 800
Published: July 8, 2024
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Sept. 2, 2024
Citation: Liu S, Song N and Subbian S (2024) Editorial: The role of transcriptional regulation in mycobacterium physiology. Front. Cell. Infect. Microbiol. 14:1483263. doi: 10.3389/fcimb.2024.1483263
Language: Английский
Citations
0
Tuberculosis, Journal Year: 2024, Volume and Issue: 149, P. 102577 - 102577
Published: Nov. 13, 2024
Language: Английский
Citations
0