Weighted gene co-expression network analysis reveals key stromal prognostic markers in pancreatic cancer DOI Creative Commons

Giovanna Mantini,

Antonio De Agostini,

M. Tufo

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 30, 2024

In recent years, it has been shown that stroma compartment can favor tumor proliferation and aggressiveness. Although extensive research with network analyses such as Weighted Gene Co-expression Network Analysis (WGCNA) conducted on pancreatic cancer its stromal components, WGCNA not previously applied to isolate identify genes associated the abundance of survival outcome from bulk RNA data. We investigated gene expression profile clinical information 140 ductal adenocarcinoma patients TCGA. analysis was performed using four modules were found be patients' traits. Specifically, one module 2459 genes, sample content. Subsequently, those further analyzed for association through log-rank test Cox regression. HPGDS ITGA9-AS1 emerged significant indicators favorable prognosis while KCMF1 YARS1 implicated in poorer prognostic outcomes. Importantly, stromal-specific TMA cohort Human Protein Atlas. Single GSEA showed is enriched signature Moffitt Puleo. These findings suggest we uncovered a specific putative markers.

Language: Английский

Local ablation disrupts immune evasion in pancreatic cancer DOI Creative Commons
Chiara Musiu, Annalisa Adamo, Simone Caligola

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217327 - 217327

Published: Nov. 1, 2024

Language: Английский

Citations

3
The possible anti-tumor effects of regulatory T cells plasticity / IL-35 in the tumor microenvironment of the major three cancer types DOI
Rehab G. Khalil, Dina Mostafa Mohammed, Hadeer M. Hamdalla

et al.

Cytokine, Journal Year: 2024, Volume and Issue: 186, P. 156834 - 156834

Published: Dec. 17, 2024

Language: Английский

Citations

3
Pancreatic ductal adenocarcinoma microenvironment: Soluble factors and cancer associated fibroblasts as modulators of NK cell functions DOI Creative Commons
Simona Carlomagno, Chiara Setti, Fulvia Ortolani

et al.

Immunology Letters, Journal Year: 2024, Volume and Issue: 269, P. 106898 - 106898

Published: July 15, 2024

Pancreatic Ductal Adenocarcinoma (PDAC) is the most frequent pancreatic cancer and represents one of aggressive human neoplasms. Typically identified at advance stage disease, PDAC tumors are unresectable resistant to standard therapies. The immunosuppressive microenvironment in impedes tumor control but a greater understanding complex stromal interactions within (TME) development strategies capable restoring antitumor effector immune responses could be crucial fight this its spread. Natural Killer (NK) cells play role immunosurveillance represent an attractive target for immunotherapies, both as cell therapy pharmaceutical target. This review describes some components TME (collagens, soluble factors fibroblasts) that can influence presence, phenotype function NK patients tissue. focused overview highlights therapeutic relevance dissecting composition define new cell-based immunotherapies improve treatment PDAC.

Language: Английский

Citations

1
Fighting Pancreatic Cancer with a Vaccine-Based Winning Combination: Hope or Reality? DOI Creative Commons
Silvia Brugiapaglia, Ferdinando Spagnolo,

Simona Intonti

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(18), P. 1558 - 1558

Published: Sept. 16, 2024

Pancreatic adenocarcinoma (PDA) represents the fourth leading cause of cancer-related mortality in USA. Only 20% patients present surgically resectable and potentially curable tumors at diagnosis, while 80% are destined for poor survival palliative chemotherapy. Accordingly, advancement innovative effective therapeutic strategies a pivotal medical imperative. It has been demonstrated that targeting immune system an approach against several solid tumors. The immunotherapy encompasses range strategies, including administration antibodies checkpoint molecules (immune inhibitors, ICIs) to disrupt tumor suppression mechanisms active immunization approaches aim stimulate host’s system. While vaccines have proved infectious agents, cancer remain unfulfilled promise. Vaccine-based therapy antigens potential be highly strategy initiating maintaining T cell recognition, enhancing response, ultimately promoting treatment success. In this review, we examined most recent clinical trials employed diverse vaccine types PDA patients’ systems, either independently or combination with chemotherapy, radiotherapy, ICIs, monoclonal ameliorating quality life extend their survival.

Language: Английский

Citations

1
Establishment of a prognostic model for pancreatic cancer based on mitochondrial metabolism related genes DOI Creative Commons

Qinwen Ba,

Xiong Wang,

Yanjun Lu

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 28, 2024

Pancreatic ductal adenocarcinoma (PAAD) is recognized as an exceptionally aggressive cancer that both highly lethal and unfavorable prognosis. The mitochondrial metabolism pathway intimately involved in oncogenesis tumor progression, however, much remains unknown this area. In study, the bioinformatic tools have been used to construct a prognostic model with metabolism-related genes (MMRGs) evaluate survival, immune status, mutation profile, drug sensitivity of PAAD patients.

Language: Английский

Citations

0
Weighted gene co-expression network analysis reveals key stromal prognostic markers in pancreatic cancer DOI Creative Commons

Giovanna Mantini,

Antonio De Agostini,

M. Tufo

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 30, 2024

In recent years, it has been shown that stroma compartment can favor tumor proliferation and aggressiveness. Although extensive research with network analyses such as Weighted Gene Co-expression Network Analysis (WGCNA) conducted on pancreatic cancer its stromal components, WGCNA not previously applied to isolate identify genes associated the abundance of survival outcome from bulk RNA data. We investigated gene expression profile clinical information 140 ductal adenocarcinoma patients TCGA. analysis was performed using four modules were found be patients' traits. Specifically, one module 2459 genes, sample content. Subsequently, those further analyzed for association through log-rank test Cox regression. HPGDS ITGA9-AS1 emerged significant indicators favorable prognosis while KCMF1 YARS1 implicated in poorer prognostic outcomes. Importantly, stromal-specific TMA cohort Human Protein Atlas. Single GSEA showed is enriched signature Moffitt Puleo. These findings suggest we uncovered a specific putative markers.

Language: Английский

Citations

0