Microecological aspects of relationship between skin microbiota and psoriasis DOI Creative Commons
Antonina A. Arsenieva, А. V. Lyamin, Н. Б. Мигачева

et al.

Clinical Microbiology and Antimicrobial Chemotherapy, Journal Year: 2024, Volume and Issue: 26(4), P. 426 - 438

Published: Jan. 1, 2024

Over the last years, influence of human microbiome on emergence non-infectious chronic diseases including psoriasis has become a popular research field. A significant goal is to get an answer following question: are changes in skin microbiota cause or consequence inflammatory process psoriasis? This review provides integrated approach problem and study relationships between microbiological landscape microecological features skin. During analysis scientific literature, such aspects were studied as living conditions microorganisms, participation maintaining homeostasis skin, impairments functions during psoriasis. In particular, various patterns deviations composition communities considered, increase ratio individual pathogens (Staphylococcus aureus Streptococcus pyogenes) decrease number microorganisms that limit growth pathogenic flora epidermidis Cutibacterium acnes). also focuses certain contradictions studies psoriasis, which most likely be caused by variable methodological approaches. It crucial develop ways studying structure, particularly at strain level, order define predictors remission exacerbations, well evaluate treatment efficacy.

Language: Английский

Unveiling causal pathways in autoimmune diseases: a multi-omics approach DOI Creative Commons

Hao Sha,

Weifeng Zhu

Autoimmunity, Journal Year: 2025, Volume and Issue: 58(1)

Published: March 26, 2025

Autoimmune diseases (ADs), such as Graves' disease (GD), Hashimoto's thyroiditis (HT), psoriasis, systemic lupus erythematosus (SLE), and type 1 diabetes (T1D), involve complex immune inflammatory responses. This study employed Mendelian randomization (MR) analysis using genome-wide association (GWAS) data to examine the causal relationships among 91 circulating proteins, 41 cytokines, 211 gut microbiota, 731 cell traits in relation ADs. Additionally, we integrated mediation bioinformatics analyses, including protein-protein interaction (PPI) networks, Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes Genomes (KEGG) pathway analysis. Subnetwork discovery key protein identification were performed Molecular Complex Detection (MCODE) plugin, alongside colocalization drug target exploration identify potential mechanisms. MR identified significant between various microbiota species, cells, ADs, with certain retaining significance after false rate (FDR) correction. Mediation demonstrated that proteins mediate pathogenic pathways linking cells psoriasis thyroiditis. PPI analyses highlighted 22 involved while subnetwork 15 central proteins. Fms-related tyrosine kinase 3 ligand (FLT3LG) exhibited strong evidence. docking confirmed several viable targets. comprehensive multi-omics advances our understanding identifies novel therapeutic targets, offers valuable insights for developing new treatment strategies.

Language: Английский

Citations

1
Gut microbiota and psoriasis: pathogenesis, targeted therapy, and future directions DOI Creative Commons
Xinyan Zou,

Xinfu Zou,

Longxia Gao

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 7, 2024

Psoriasis is one of the most common autoimmune skin diseases. Increasing evidence shows that alterations in diversity and function microbiota can participate pathogenesis psoriasis through various pathways mechanisms.

Language: Английский

Citations

7
The efficacy and safety of probiotics in the adjuvant treatment of psoriasis: a systematic review and meta-analysis of randomized controlled trials DOI Creative Commons
Yiran Zhu, Fan Xu, Hao Chen

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 6, 2024

It has been reported that the imbalance of gut microbiota is involved in pathogenesis psoriasis. We retrieved randomized placebo-controlled trials to evaluate efficacy and safety probiotic administration treatment

Language: Английский

Citations

3
Unravelling the role of the skin microbiome in immunodermatological diseases: implications for therapeutic interventions DOI Open Access

Haily Fritts,

Kelly Frasier,

Grace Herrick

et al.

International Journal of Research in Dermatology, Journal Year: 2025, Volume and Issue: 11(2), P. 190 - 198

Published: Feb. 24, 2025

The skin microbiome, comprising diverse microbial communities, is pivotal in maintaining cutaneous homeostasis and modulating immune responses immunodermatological diseases. This review provides an overview of recent research investigating the interplay between microbiome autoimmune, allergic, inflammatory conditions, such as psoriasis, eczema, acne vulgaris. Current evidence suggests that alterations composition, termed dysbiosis, may contribute to disease pathogenesis exacerbate inflammation disorders. Furthermore, microbial-derived metabolites immune-modulating factors produced by commensal bacteria can influence local barrier function. Future directions include evaluating how interacts with host system, identifying biomarkers for diagnosis prognosis, exploring microbiome-targeted therapeutic interventions, probiotics, transplantation, metabolite supplementation. By leveraging insights from research, personalized approaches managing diseases offer novel avenues restoring improving patient outcomes.

Language: Английский

Citations

0
Emerging Novel Therapies for the Treatment of Psoriasis: A Narrative Review DOI Open Access

Alan D. Kaye,

Nicolas R. Thompson,

Camille B Coreil

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Psoriasis is a chronic autoimmune and autoinflammatory disorder defined by abnormal skin cell turnover inflammation, resulting in the formation of plaques on skin. Although biologic therapies targeting interleukin (IL)-17 IL-23 have significantly improved treatment landscape for moderate-to-severe psoriasis, they are not effective all patients. This highlights need additional therapeutic strategies. In recent years, exploring novel avenues such as IL-21, small nucleolar RNA (snoRNA) Snora73, gut microbiome, natural remedies shown increasing promise managing psoriasis. Interleukin-21 cytokine that plays critical role differentiation function Th17 cells, which central to pathogenesis Recent studies demonstrated neutralizing IL-21 with specific antibodies can help restore immune homeostasis, reducing disease severity improving patient outcomes. Targeting may be particularly beneficial patients resistant conventional like IL-17 inhibitors. addition snoRNA Snora73 has emerged target psoriasis treatment. regulates proliferation interacting miR-3074-5p pre-B-cell leukemia homeobox 1 (PBX1), promoting The microbiome increasingly recognized its diseases, including Imbalances been linked exacerbation, triggering systemic inflammation altering responses. Moreover, various treatments gained attention their anti-inflammatory properties. These could serve adjuncts existing treatments, offering complementary approach minimizes side effects while well utilizing provide new opportunities more effective, personalized management

Language: Английский

Citations

0
Research Progress on the Influence and Mechanism of Bile Acid Metabolism in Digestive System Tumors DOI Open Access

洁 云

Journal of Clinical Personalized Medicine, Journal Year: 2025, Volume and Issue: 04(02), P. 85 - 91

Published: Jan. 1, 2025

Language: Английский

Citations

0
Characterization of the Gut Microbiota in Patients with Psoriasis: A Systematic Review DOI Creative Commons

Yingjun Gao,

Yanfeng Lou,

Yun Hui

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(4), P. 358 - 358

Published: April 7, 2025

Background: Psoriasis is a prevalent and persistent inflammatory disorder with systemic manifestations. Emerging evidence implicates the gut microbiota in regulating responses, metabolic pathways, immune homeostasis. This review synthesizes current on dysbiosis psoriasis evaluates therapeutic potential of probiotics fecal transplantation (FMT) disease management. Method: Following PRISMA guidelines, we systematically reviewed studies investigating microbiome profiles through MEDLINE, EMBASE, Web Science databases (January 2015-December 2024). Included utilized 16S rRNA gene sequencing or metagenomic analyses for microbial characterization. Results: Comparative revealed distinct patterns patients compared healthy controls, although specific signatures exhibited inconsistencies across studies. Notably, interventions modulating composition-particularly probiotic supplementation-demonstrated measurable improvements severity scores markers. Conclusions: Gut modulation represents promising strategy psoriasis; however, highlights need standardized analysis methodologies larger longitudinal to establish causality. Future research should prioritize functional characterization microbiota-host interactions optimize applications.

Language: Английский

Citations

0
Critical Role of Skin in Pathogenesis: Bidirectional Crosstalk Between Skin and Multiple Organs DOI Creative Commons

Wen‐De Deng,

Junyi Liu,

C Tang

et al.

MedComm – Future Medicine, Journal Year: 2025, Volume and Issue: 4(2)

Published: May 25, 2025

ABSTRACT The skin, the largest organ in human body, serves both as a mechanical barrier and an autonomous lymphoid organ, protecting against various environmental threats while maintaining balance functionality of multiple bodily systems. This relationship extends beyond skin itself, involving other organs closely linked to homeostasis related diseases. However, systematic reviews this area are still lacking. review seeks explore bidirectional communication, with particular focus on critical role immune system. We present comprehensive latest evidence, highlighting fundamental roles cells cytokines within skin–organ axis, particularly IL‐17A, which appears interact nearly all organs, illustrating their interplay impact health. Additionally, we discuss implications these interactions for design application skin‐on‐a‐chip organ‐on‐a‐chip technologies, emphasizing importance understanding relationships developing physiologically relevant vitro models. By providing analysis complex interactions, establishes solid theoretical foundation prevention, diagnosis, treatment diseases associated regarding cells, cytokines, microorganisms, metabolites, ultimately aiming advance research fields offer new insights clinical applications.

Language: Английский

Citations

0
Multi-omics analysis of outer membrane vesicles from P. goldsteinii in a psoriasis mouse model DOI
Anqi Du, Jiayu Chen, Zhaoxiang Xie

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123776 - 123776

Published: May 1, 2025

Language: Английский

Citations

0
The interplay between epidermal barrier distribution, microbiota composition, and immune infiltrate defines and stratifies psoriasis patients and is associated with disease severity DOI Creative Commons
Elizabeth M. Ortega-Rocha, Paul Hernández‐Herrera,

Sofia V de Los Santos-Carmona

et al.

Journal of Translational Autoimmunity, Journal Year: 2024, Volume and Issue: 9, P. 100257 - 100257

Published: Nov. 1, 2024

Psoriasis is a chronic inflammatory autoimmune skin disease characterized by keratinocyte hyperproliferation, primarily driven the IL-23/IL-17 axis. In addition to immune response, various components, including epidermal barrier and microbiota, have been individually implicated in pathogenesis. Here, we aimed investigate interplay between tight junctions, Staphylococcus aureus enterotoxin B (SEB), CD4 T cell-mediated responses. By immunofluorescence analyses of biopsies, observed that claudin-1 distribution was significantly altered psoriatic patients, which correlated with localization

Language: Английский

Citations

1