Extracellular vesicles derived from mesenchymal stem cells alleviate renal fibrosis via the miR-99b-5p/mTOR/autophagy axis in diabetic kidney disease

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 18, 2025

Diabetic kidney disease (DKD) is the leading cause of end-stage renal (ESRD) globally, presenting a significant therapeutic challenge. Extracellular vesicles (EVs) from mesenchymal stem cells (MSCs) have emerged as promising agents. This study explored effects and mechanisms EVs derived human placental (hP-MSCs) on DKD. were isolated cultured hP-MSCs administered to streptozotocin (STZ)-induced diabetic mice high glucose–treated glomerular mesangial cells. The impact was assessed through histological analysis biochemical assays. miR-99b-5p expression in its role modulating mechanistic target rapamycin (mTOR)/autophagy pathway examined via western blotting RT‒qPCR. Treatment with hP-MSC-derived significantly alleviated fibrosis improved function DKD models. These enriched miR-99b-5p, which targeted inhibited mTOR signaling, thereby increasing autophagic activity reducing cellular proliferation extracellular matrix accumulation tissues. can mitigate injury by miR-99b-5p/mTOR/autophagy pathway. findings suggest potential cell-free strategy for managing

Language: Английский

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Necroptosis: a significant and promising target for intervention of cardiovascular disease

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116951 - 116951

Published: April 1, 2025

Language: Английский

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Regulated Cell Death Pathways in Pathological Cardiac Hypertrophy

Reviews in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 25(10)

Published: Oct. 11, 2024

Cardiac hypertrophy is characterized by an increased volume of individual cardiomyocytes rather than increase in their number. Myocardial due to pathological stimuli encountered the heart, which reduces pressure on ventricular walls maintain cardiac function, known as hypertrophy. This eventually progresses heart failure. Certain varieties regulated cell death (RCD) pathways, including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagy, are crucial development review summarizes molecular mechanisms signaling pathways underlying these RCD focusing mechanism action findings for It intends provide new ideas developing therapeutic approaches targeted at cellular level prevent or reverse

Language: Английский

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The Potential of Mesenchymal Stem Cell-Derived Exosomes in Cardiac Repair

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13494 - 13494

Published: Dec. 17, 2024

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and effectively repairing heart following myocardial injuries remains a significant challenge. Research has increasingly shown that exosomes derived from mesenchymal stem cells (MSC-Exo) can ameliorate improve outcomes after such injuries. The therapeutic benefits MSC-Exo largely due to their capacity deliver specific cargo, including microRNAs proteins. modulate various signaling pathways provide several beneficial effects, cytoprotection, inflammation modulation, angiogenesis promotion help repair damaged myocardium. In this review, we summarize cardioprotective effects in injury, underlying molecular mechanism involved process, approaches studied enhance efficacy based on recent findings.

Language: Английский

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