Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 12, 2024
Background
Hyperthyroidism
is
an
endocrine
disorder
with
a
relatively
low
global
prevalence
but
significantly
higher
incidence
among
females
compared
to
males.
The
onset
age
primarily
ranges
from
30
50,
although
it
not
limited
this
group.
Challenges
in
the
treatment
of
hyperthyroidism
include
individualized
plan
formulation,
management
side
effects,
and
prediction
disease
progression,
necessitating
comprehensive
consideration
achieve
more
effective
therapy
management.
Mendelian
randomization
studies
can
reveal
precise
therapeutic
targets
between
blood
urine
biomarkers
hyperthyroidism,
providing
decadent
options
for
condition.
Methods
study
will
build
upon
omics
(MR)
framework
by
conducting
MR
analysis
using
35
separately
two
distinct
databases
hyperthyroidism.
Subsequently,
results
undergo
meta-analysis
multiple
corrections
ensure
accuracy
reliability.
Finally,
positive
findings
reverse
validation
verify
causal
relationships
Results
In
British
database,
Total
bilirubin
levels
about
yielded
odds
ratio
(
OR
)
1.097
(95%
CI
:
0.951-1.265,
P
=
0.205).
Conversely,
Thyroid
Omics
Association
revealed
1.283
1.122-1.467,
0.0002)
same
relationship.
Meta-analysis
both
databases,
following
corrections,
resulted
1.192
1.081-1.314,
0.015).
Additionally,
direction
beta
values
was
consistent.
Conclusion
biomarker
total
may
contribute
increased
risk
accelerate
its
thus
representing
factor
Genes,
Journal Year:
2024,
Volume and Issue:
15(9), P. 1183 - 1183
Published: Sept. 9, 2024
Background:
Hepatocellular
carcinoma
(HCC)
is
a
primary
malignant
liver
tumor
characterized
by
low
survival
rate
and
high
mortality.
This
study
aimed
to
investigate
the
causal
effect
of
immune
cell
phenotypes,
plasma
metabolites,
HCC
in
East
Asian
populations.
Methods:
The
summary
results
for
731
immunocytes,
1400
HCCs
were
acquired
from
publicly
available
genome-wide
association
studies
(GWASs).
utilized
two-sample
Mendelian
randomization
(MR)
analysis
establish
relationships,
which
was
achieved
employing
various
statistical
methods
including
inverse
variance-weighted,
simple
mode,
MR–Egger,
weighted
median,
mode.
Multiple
sensitivity
analyses
conducted
confirm
reliability
MR
data.
Ultimately,
mediation
employed
ascertain
path
that
leads
immunocytes
metabolites.
Results:
Among
20
cells
Asians,
links
found,
with
one
showing
an
correlation.
In
addition,
36
metabolites
significantly
associated
Asians.
Through
established
causative
we
identified
strong
correlation
between
glycerophospholipid
metabolic
pathway
By
two-step
analysis,
11
are
causally
linked
Asians
through
14
Linolenate
[α
or
γ;
(18:3n3
6)]
levels
highest
proportion
(19.3%).
Conclusions:
Our
findings
affirm
among
eastern
Asia
populations
calculating
percentage
impact
influenced
offers
innovative
perspectives
on
early
detection,
diagnosis,
therapy
HCC.
European Journal of Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
54(12)
Published: Sept. 15, 2024
Inflammatory
cytokines
and
migraines
have
been
associated
in
previous
research,
but
the
underlying
mechanisms
of
action
are
still
elusive.
The
biological
functions
metabolites
crucial
onset
migraine.
Our
goals
were
to
clarify
cause-and-effect
connection
between
inflammatory
explore
potential
mediating
function
metabolites.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 9, 2024
Immune
system
regulation
is
a
key
indicator
of
the
gut
microbiota
(GM)
influencing
disease
development.
The
causal
role
GM
in
Guillain-Barré
syndrome
(GBS)
and
whether
it
can
be
mediated
by
immune
cells
unknown.
Genome-wide
association
study
(GWAS)
summary
statistics
for
were
obtained
from
Dutch
Microbiota
Project
(n
=
7,738)
FINRISK
2002
(FR02)
cohort
5,959).
Inverse
variance
weighting
method
(IVW)
used
as
main
to
evaluate
relationship
between
GBS.
Subsequently,
mediating
effects
731
traits
evaluated.
Additionally,
we
also
executed
Bayesian
Weighting
algorithm
verification.
Mendelian
randomization
(MR)
analysis
determined
protective
effect
pyrimidine
deoxyribonucleoside
degradation
superpathway
on
GBS
(IVW:
P
0.0019,
OR
0.4508).
It
worth
noting
that
GBS,
proportions
herpesvirus
entry
mediator
(HVEM)
(
HVEM
CM
CD4
+
,
naive
CD45RA
-
CD8br)
T
cell
maturation
stage
-0.0398,
-0.0452,
-0.0414,
-0.0425,
accounting
5.00%,
5.67%,
5.19%
5.34%
total
effect.
11
types
intestinal
bacteria
might
involved
deoxyriboside
superpathway,
including
Staphylococcus
A
fleurettii,
AR31,CAG-274
sp000432155,
Photobacterium,
Acetobacteraceae,
Dysgonomonadaceae,
NK4A144,Leptospirae,
CAG-81
sp000435795,
Leptospirales
CAG-873
sp001701165.
This
suggests
there
which
may
CD8
cells.
As
bidirectional
molecular
switch,
plays
an
important
regulation.
flora
found
their
changes
related
occurrence
However,
extensive
research
still
warranted
before
microbiome
sequencing
prevention
targeted
treatment
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 7, 2024
AbstractBackground：IgA
nephropathy
(IgAN)
is
an
immune-inflammatory
glomerulonephritis
mediated
by
both
genetic
and
environmental
factors.
Recent
research
indicates
a
close
association
between
gut
microbiota
dysbiosis
IgAN
development.
Additionally,
circulating
inflammatory
proteins
also
play
significant
role
in
the
progression
of
IgAN.However,
causal
relationship
among
microbiota,
proteins,
remains
unclear.
Methods：This
study
utilized
publicly
available
genome-wide
(GWAS)
data
for
Mendelian
randomization
(MR)
analysis
to
investigate
IgAN,
as
well
examine
mediating
IgAN.
The
primary
analytical
method
employed
this
was
inverse
variance-weighted
(IVW)
with
specific
attention
given
Bayesian-weighted
MR
results
supported
MR-Egger
regression,
weighted
median,
median
model
simple
approaches.
Several
sensitivity
analyses
were
performed
evaluate
robustness
findings.
Results：(1)MR
negative
associations
g_Roseburia,
g_Faecalibacterium,
s_Odoribacter_splanchnicus,
s_Roseburia_unclassified
risk,
while
positive
exist
s_Paraprevotella_unclassified
s_Lachnospiraceae_bacterium_7_1_58FAA
risk.(2)
Circulating
showed
that
IL-10RA
negatively
correlated
risk
TSGP-CD5,
FGF23,
LIF,
TGF-α
levels
positively
IgAN.(3)Mediation
suggests
TGF-αserves
mediator
s_Odoribacter_splanchnicus
causality
(4)
reverse
suggest
no
effect
on
flora
proteins.Sensitivity
consistently
support
reliability
results.
Conclusion：Our
findings,
obtained
through
methods,
substantiate
link
identification
biomarkers
offers
novel
insights
into
potential
mechanisms
underlying
which
can
be
advantageous
early
diagnosis
development
more
effective
treatment
strategies.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 12, 2024
Background
Lichen
planus
(LP),
an
autoimmune
disorder,
remains
incompletely
understood
in
terms
of
its
etiological
mechanisms.
This
study
aims
to
elucidate
causal
relationships
among
immune
cell
populations,
plasma
metabolites,
and
lichen
using
Mendelian
randomization
(MR)
techniques.
Methods
Employing
a
two-sample,
two-step
MR
approach,
with
single
nucleotide
polymorphisms
(SNP)
serving
as
genetic
instruments
for
both
exposures
mediators,
this
minimizes
biases
from
confounding
reverse
causality.
Leveraging
summary
statistics
genome-wide
association
studies
(GWAS)
involving
731
traits
(N
=
3757),
1091
metabolite
8299),
367668),
inverse
variance
weighting
(IVW)
is
adopted
the
primary
analytical
method.
The
total
effect
cells
on
LP
decomposed
into
direct
indirect
effects
mediated
by
metabolites.
Results
analysis
reveals
associations
28
38
metabolites
(
P
IVW
<
0.05).
Specifically,
NK
%
lymphocyte
shows
negatively
correlated
(OR
0.952;
95%
CI:
[0.910,
0.995],
0.030).
Among
Picolinate
significantly
contributes,
explaining
16.4%
(95%
[28.3%,
4.54%])
between
LP.
Conclusion
These
findings
support
potential
protective
LP,
partially
levels.
Thus,
interventions
targeting
levels
may
mitigate
burden
attributed
low
counts.
provides
new
evidence
insights
pathogenesis
planus,
advancing
our
understanding
underlying
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 9, 2024
Abstract
Background
Hepatocellular
carcinoma
(HCC)
is
a
primary
malignant
liver
tumor,
characterized
by
notably
low
5-year
survival
rate
and
high
mortality
globally.
This
study
aimed
to
investigate
the
causal
effect
between
immune
cell
phenotypes,
plasma
metabolites,
HCC.
Methods
Summary
statistics
of
731
immunocytes
traits
(N
=
3,757),
1,400
metabolite
8,299)
HCC
trait
197,611)
were
obtained
from
publicly
available
genome-wide
association
studies
(GWAS).
Two-sample
Mendelian
randomization
(MR)
analysis
was
applied
infer
links
using
inverse
variance-weighted,
simple
mode,
MR-Egger,
weighted
median,
mode.
Several
sensitivity
analyses
performed
ensure
reliable
MR
results.
Finally,
we
used
mediation
identify
pathway
mediated
metabolites.
Results
Causal
relationships
identified
among
20
phenotypes
with
one
exhibiting
reverse
causality.
Additionally,
36
metabolites
causally
related
Based
on
known
observed
that
glycerophospholipid
metabolism
closely
Utilizing
two-step
analysis,
11
determined
have
14
Linolenate
[alpha
or
gamma;
(18:3n3
6)]
levels
showing
highest
proportion
(19.3%).
Conclusion
Our
findings
affirm
relationship
HCC,
computing
provides
novel
insights
into
prevention,
diagnosis,
treatment
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 12, 2024
Background
Hyperthyroidism
is
an
endocrine
disorder
with
a
relatively
low
global
prevalence
but
significantly
higher
incidence
among
females
compared
to
males.
The
onset
age
primarily
ranges
from
30
50,
although
it
not
limited
this
group.
Challenges
in
the
treatment
of
hyperthyroidism
include
individualized
plan
formulation,
management
side
effects,
and
prediction
disease
progression,
necessitating
comprehensive
consideration
achieve
more
effective
therapy
management.
Mendelian
randomization
studies
can
reveal
precise
therapeutic
targets
between
blood
urine
biomarkers
hyperthyroidism,
providing
decadent
options
for
condition.
Methods
study
will
build
upon
omics
(MR)
framework
by
conducting
MR
analysis
using
35
separately
two
distinct
databases
hyperthyroidism.
Subsequently,
results
undergo
meta-analysis
multiple
corrections
ensure
accuracy
reliability.
Finally,
positive
findings
reverse
validation
verify
causal
relationships
Results
In
British
database,
Total
bilirubin
levels
about
yielded
odds
ratio
(
OR
)
1.097
(95%
CI
:
0.951-1.265,
P
=
0.205).
Conversely,
Thyroid
Omics
Association
revealed
1.283
1.122-1.467,
0.0002)
same
relationship.
Meta-analysis
both
databases,
following
corrections,
resulted
1.192
1.081-1.314,
0.015).
Additionally,
direction
beta
values
was
consistent.
Conclusion
biomarker
total
may
contribute
increased
risk
accelerate
its
thus
representing
factor
