Using lifestyle interventions and the gut microbiota to improve PTSD symptoms DOI Creative Commons
Steven G. Sugden, Gia Merlo

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 3, 2024

Posttraumatic stress disorder is part of a spectrum psychological symptoms that are frequently linked with single defining traumatic experience. Symptoms can vary over the lifespan in intensity based on additional life stressors, individual stability, and connectedness to purpose. Historically, treatment has centered psychotropic agents group therapy increase individual's window tolerance, improve emotional dysregulation, strengthen relationships. Unfortunately, there growing segment individuals posttraumatic who do not respond these traditional treatments, perhaps because they address multidirectional relationships between chronic cortisol, changes brain gut microbiota system, neuroinflammation, symptoms. We will review literature explain how trauma impacts neuroendocrine neuroimmunology within brain, processes influence provide mechanism for development Finally, we show lifestyle psychiatry model provides symptom amelioration.

Language: Английский

Post Traumatic Stress Disorder associated Hypothalamic-Pituitary-Adrenal Axis Dysregulation and Physical Illness DOI Creative Commons

Stephanie Lawrence,

R. Hal Scofield

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 41, P. 100849 - 100849

Published: Aug. 23, 2024

Language: Английский

Citations

7
Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review DOI Creative Commons
Pavlo Petakh, Khrystyna Duve, Valentyn Oksenych

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: June 3, 2024

This mini-review explores the role of short-chain fatty acids (SCFAs) in posttraumatic stress disorder (PTSD). Highlighting microbiota-gut-brain axis, this study investigated bidirectional communication between gut microbiome and mental health. SCFAs, byproducts microbial fermentation, have been examined for their potential impact on PTSD, with a focus molecular mechanisms therapeutic interventions. review discusses changes SCFA levels bacterial profiles individuals emphasizing need further research. Promising outcomes from clinical trials using probiotics fermented formulations suggest avenues PTSD management. Future directions involve establishing comprehensive human cohorts, integrating multiomics data, employing advanced computational methods, goal deepening our understanding SCFAs exploring microbiota-targeted

Language: Английский

Citations

5
Genetic and peripheral biomarkers of comorbid posttraumatic stress disorder and traumatic brain injury: a systematic review DOI Creative Commons
Kiriana K. Cowansage,

Reshmi Nair,

Jose Lara‐Ruiz

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

Background Posttraumatic stress disorder (PTSD) commonly cooccurs with traumatic brain injury (TBI) in military populations and is a significant predictor of poor long-term outcomes; however, it unclear to what extent specific biological variables are associated comorbidity. This PROSPERO-registered systematic review evaluates the current body literature on genetic peripheral biomarkers comorbid TBI PTSD. Methods Searches were conducted four databases (PubMed, PsycInfo, PTSDPubs, Scopus). We included published studies examining differences among civilian, military, veteran participants both PTSD compared those alone as well as, some cases, healthy controls. Data extracted from evidence quality was assessed. Results Our final analysis 16 studies, majority which based data active duty participants. The results suggest that multiple gene variants likely contribute cumulative risk TBI. An elevated circulating level pro-inflammatory cytokine IL-6 most consistently replicated blood-based indicator illness, mTBI alone. Conclusion Several protein markers cellular inflammation appear be promising indicators chronic pathology Additional research needed determine how such factors indicate, predict, comorbidity they represent viable targets for development novel diagnostic tools therapeutic interventions.

Language: Английский

Citations

0
Gut–Brain Axis and Brain Microbiome Interactions from a Medical Perspective DOI Creative Commons
Borros Arneth

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 167 - 167

Published: Feb. 8, 2025

Background: The gut microbiome directly impacts brain health and activity, meaning the two are closely associated. This relationship suggests a link between microbial imbalances diseases such as Alzheimer’s, although multiple other contributing factors, genetics, also play part. Additionally, recent studies discovered that cerebrospinal fluid has some deoxyribonucleic acid (DNA), which can be interpreted to mean exists in too. vagus nerve central nervous immune systems responsible for connection microbiome. Aims Objectives: main aim of this systematic review is analyze existing research on gut–brain axis fill current knowledge gap. Materials Methods: A search was conducted PubMed database based set predefined MeSH terms. Results: After search, 2716 articles meeting parameters were found PubMed. list then downloaded analyzed according inclusion/exclusion criteria, 63 relevant papers selected. Discussion: Bacteria produce substances considered neuroactive. These compounds or indirectly affect function through axis. However, various gaps mechanisms involved need addressed first.

Language: Английский

Citations

0
Gut Microbes: Therapeutic Target for Neuropsychiatric Disorders DOI
Keya Mallick, Gopal Khodve,

Ritika Ruwatia

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 27 - 38

Published: Feb. 21, 2025

Language: Английский

Citations

0
Serogroup Distribution of Leptospira Among Humans and Rodents in Zakarpattia Oblast, Ukraine (2018–2023) DOI Creative Commons
Pavlo Petakh, Oleksandr Kamyshnyi

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 614 - 614

Published: March 7, 2025

Leptospirosis is a zoonotic disease caused by Leptospira bacteria, which affects both humans and animals. This study investigated the prevalence of serogroups in human rodent reservoirs across Zakarpattia Oblast, Ukraine, from 2018 to 2023. The objective was identify epidemiological patterns assess potential public health risks. Data were sourced Public Health Center Ukraine regional surveillance initiatives, encompassing reported cases rodent-carrier detection. Six main serogroups—Icterohaemorrhagiae, Pomona, Grippotyphosa, Hebdomadis, Canicola, Tarassovi—were included analysis. results showed that Pomona Hebdomadis became more common data different districts also differences, with Icterohaemorrhagiae being most frequent rodents. Other serogroups, like Grippotyphosa found less often. Rodents may be an important source leptospirosis Zakarpattia. growing number recent years shows need for improved monitoring, control, prevention region.

Language: Английский

Citations

0
Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence DOI Open Access
В. Э. Цейликман,

Olga B. Tseilikman,

Oleg N. Yegorov

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2856 - 2856

Published: Aug. 26, 2024

The medicinal properties of resveratrol have garnered increasing attention from researchers. Extensive data been accumulated on its use in treating cardiovascular diseases, immune system disorders, cancer, neurological and behavioral disorders. protective mechanisms resveratrol, particularly anxiety-related stress well documented. However, less has given to the side effects resveratrol. This review explores not only underlying anxiolytic but also that may lead increased anxiety following treatment. Understanding these is crucial for enhancing efficacy managing disorders associated with PTSD.

Language: Английский

Citations

3
New recognition of the heart–brain axis and its implication in the pathogenesis and treatment of PTSD DOI

Haipeng Li,

Hongliang Cheng,

Keke Ding

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(4), P. 4661 - 4683

Published: July 23, 2024

Abstract Post‐traumatic stress disorder (PTSD) is a complex psychological provoked by distressing experiences, and it remains without highly effective intervention strategies. The exploration of PTSD's underlying mechanisms crucial for advancing diagnostic therapeutic approaches. Current studies primarily explore PTSD through the lens central nervous system, investigating concrete molecular alterations in cerebral area neural circuit irregularities. However, body's response to external stressors, particularly changes cardiovascular function, often pronounced, evidenced notable cardiac dysfunction. Consequently, examining with focus on function vital early prevention targeted management disorder. This review undertakes comprehensive literature analysis detail brain heart structures functions associated PTSD. It also synthesizes potential heart–brain axis interactions relevant development Ultimately, considering this proposes novel perspectives prophylaxis therapy.

Language: Английский

Citations

1
Gut microbiotas, inflammatory factors, and mental-behavioral disorders: A mendelian randomization study DOI Creative Commons
Zhen Ma,

Huanghong Zhao,

Min Zhao

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

0
Using lifestyle interventions and the gut microbiota to improve PTSD symptoms DOI Creative Commons
Steven G. Sugden, Gia Merlo

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 3, 2024

Posttraumatic stress disorder is part of a spectrum psychological symptoms that are frequently linked with single defining traumatic experience. Symptoms can vary over the lifespan in intensity based on additional life stressors, individual stability, and connectedness to purpose. Historically, treatment has centered psychotropic agents group therapy increase individual's window tolerance, improve emotional dysregulation, strengthen relationships. Unfortunately, there growing segment individuals posttraumatic who do not respond these traditional treatments, perhaps because they address multidirectional relationships between chronic cortisol, changes brain gut microbiota system, neuroinflammation, symptoms. We will review literature explain how trauma impacts neuroendocrine neuroimmunology within brain, processes influence provide mechanism for development Finally, we show lifestyle psychiatry model provides symptom amelioration.

Language: Английский

Citations

0