Dissecting casual effects of diet on the risk of inflammatory bowel disease and the potential mediation by gut microbiota: a Mendelian randomization study

Food, Nutrition and Health., Journal Year: 2025, Volume and Issue: 2(1)

Published: Jan. 3, 2025

Abstract Background Diet plays a fundamental role in maintaining intestinal health. Here, we investigated whether there is the causal association of diet with inflammatory bowel disease (IBD), and potential effect gut microbiota on these relationships, by using two-sample Mendelian randomization (MR) analyses. Materials methods Genetic instruments for 29 dietary intake variables 139 food-liking traits were obtained from UK-Biobank. The GWAS statistics IBD its two subtypes, ulcerative colitis (UC) Crohn's (CD), IEU database. microbiome was MiBioGen alliance. Associations assessed inverse-variance weighted method, MR-Egger, median, simple mode mode. Gut mediated associations IBD. Results We identified between 21 factors (including 3 18 traits) IBD, UC and/or CD. These affected 22 bacteria genera, among them, 9 causally associated risk. Notably, Ruminococcus_torques_group , symbiotic bacterium possessing anti-inflammatory properties, significantly relationship various (e.g., liking acquired taste, strong flavor, blue cheese beans) risks. Ruminococcaceae UCG003 showed significant mediating efficacy relation sharp flavor Conclusion Our study reveals impacts risk provides novel insights modulating as therapeutic targets prevention.

Language: Английский

Mendelian randomization analysis revealed a gut microbiota-eye axis in acute anterior uveitis

Eye, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский