The clinical significance of T-cell regulation in hypertension treatment

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

Hypertension, a globally prevalent condition, is closely associated with T cell-mediated inflammatory responses. Studies have shown that cells, by secreting pro-inflammatory cytokines such as interferon-gamma (IFN-γ), Interleukin-17 (IL-17), and Tumor necrosis factor-alpha (TNF-α), directly lead to vascular dysfunction elevated blood pressure. The activation of Th1 Th17 cell subsets, along the regulatory cells (Tregs), critical mechanism in onset progression hypertension. This review explores role pathophysiology hypertension discusses potential therapeutic strategies targeting regulation, immunotherapy gene-editing technologies. These emerging treatments hold promise for providing personalized options hypertensive patients, reducing complications, improving treatment outcomes.

Language: Английский

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Rheumatoid Arthritis and Tuberculosis

International Journal of Rheumatic Diseases, Journal Year: 2025, Volume and Issue: 28(3)

Published: March 1, 2025

Language: Английский

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Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complications in a rat model of rheumatic heart disease

mBio, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

ABSTRACT Acute rheumatic fever (ARF) is an autoimmune disease triggered by antibodies and T cells targeting the group A Streptococcus (GAS, Strep A) bacterium, often leading to heart (RHD) Sydenham’s chorea. Long-term monthly penicillin injections are recognized as a cornerstone of public health programs prevent reinfection progression ARF. However, compliance poor, better tools required slow progression. Preclinical evidence suggests that this can be achieved. Using rat model replicates post-streptococcal complications, we explored potential low-dose interleukin-2 (LD-IL-2) immunotherapeutic intervention for ARF/RHD. In model, recombinant M protein from type 5 (rM5) Lewis rats induce cardiac tissue inflammation, conduction abnormalities, cross-reactive against brain proteins central pathogenesis. animals injected with rM5 treated LD-IL-2, no functional or histological changes was observed. LD-IL-2 therapy effectively reduced production raised host significantly increased regulatory in mediastinal lymph nodes. These novel findings suggest will effective agent treating ARF has replace standard injections. IMPORTANCE Post-streptococcal syndromes, including acute fever, disease, chorea, represent significant yet under-recognized economic burden. This especially true low-income countries among Indigenous populations high-income nations, where burden most severe. conditions arise response infections, long-term disability, premature death. Despite their widespread impact, vaccine currently available reinfections, specific exists treat resulting process. study uses evaluate interleukin 2 improving clinical outcomes reducing incidence diseases streptococcal infections.

Language: Английский

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Polypropylene sulfide methotrexate nanoparticles target the synovial lymphatic system to restore immune tolerance in rheumatoid arthritis

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124713 - 124713

Published: Sept. 1, 2024

Language: Английский

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The significance of RB1 in multiple myeloma

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 27, 2024

The treatment of multiple myeloma (MM) has significantly advanced; however, the underlying genetic mechanisms remain elusive. Clonal events and alterations are recognized as pivotal in pathogenesis MM. It is now understood that a multitude gene mutations, including those affecting RAS,

Language: Английский

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