Integrating ADMET, enrichment analysis, and molecular docking approach to elucidate the mechanism of Artemisia herba alba for the treatment of inflammatory bowel disease-associated arthritis

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: 87(20), P. 836 - 854

Published: July 19, 2024

Inflammatory Bowel Disease-Associated Arthritis (IBD-associated arthritis) poses a significant challenge, intertwining the complexities of both inflammatory bowel disease (IBD) and arthritis, significantly compromising patient quality life. While existing medications offer relief, these drugs often initiate adverse effects, necessitating requirement for safer therapeutic alternatives.

Language: Английский

Shared genetic architecture between COVID-19 and irritable bowel syndrome: a large-scale genome-wide cross-trait analysis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 15, 2024

Background It has been reported that COVID-19 patients have an increased risk of developing IBS; however, the underlying genetic mechanisms these associations remain largely unknown. The aim this study was to investigate potential shared SNPs, genes, proteins, and biological pathways between IBS by assessing pairwise correlations cross-trait analysis. Materials methods We assessed correlation three phenotypes using linkage disequilibrium score regression (LDSC) high-definition likelihood (HDL) methods. Two different sources data were combined METAL, Multi-trait analysis GWAS (MTAG) method applied for multi-trait enhance statistical robustness discover new associations. Independent loci examined genome-wide complex trait (GCTA)-conditional joint (COJO), multi-marker genomic annotation (MAGMA), functional mapping (FUMA), integrating various QTL information further identify genes proteins. Gene set variation (GSVA) employed compute pleiotropic gene scores, with immune infiltration algorithms, categorized into high low groups. Results found a positive infection, hospitalization, IBS. Subsequent identified nine significantly associated loci. Among these, eight variants closely related comorbidity COVID-19. also highlighted four 231 proteins susceptibility through analytical strategies stratification approach populations. Conclusions Our reveals architecture two diseases, providing insights laying groundwork more effective interventions.

Language: Английский

Review of interleukin-6 polymorphisms in rheumatoid arthritis: a genetic implications

Journal Of Advanced Pharmacy Education And Research, Journal Year: 2024, Volume and Issue: 14(3), P. 109 - 117

Published: Jan. 1, 2024

Language: Английский