Cannabichromene as a Novel Inhibitor of Th2 Cytokine and JAK/STAT Pathway Activation in Atopic Dermatitis Models DOI Open Access

Ki-Chan Kim,

Ga Hee Jeong, Chul Hwan Bang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13539 - 13539

Published: Dec. 18, 2024

Cannabichromene (CBC) is one of the main cannabinoids found in cannabis plant, and although less well known than tetrahydrocannabinol (THC) cannabidiol (CBD), it gaining attention for its potential therapeutic benefits. To date, CBC’s mechanisms action include anti-inflammatory, analgesic, antidepressant, antimicrobial, neuroprotective, anti-acne effects through TRP channel activation inhibition inflammatory pathways, suggesting that may have treatment skin diseases, such as atopic dermatitis (AD), but exact mechanism remains unclear. Therefore, this study, we investigated CBC on Th2 cytokines along with Janus kinase (JAK)/signal transducer activator transcription (STAT) pathways involved AD pathogenesis. We used a 2,4-Dinitrochlorobenzene (DNCB)-induced BALB/c mouse model to topically administer (0.1 mg/kg or 1 mg/kg). The results showed lesion severity, ear thickness, epithelial thickness dorsal skin, mast cell infiltration were significantly reduced 0.1 CBC-treated group compared DNCB-treated (p < 0.001). In addition, real-time quantitative reverse polymerase chain reaction (qRT-PCR) analysis significant decrease mRNA expression (TSLP, IL-4, IL-13) mediators (IFN-γ, IL-1β, IL-6, IL-17, IL-18, IL-33) 0.05). Western blot also revealed JAK1, JAK2, STAT1, STAT2, STAT3, STAT6 protein These suggest promising candidate demonstrates alleviate symptoms by suppressing immune response.

Language: Английский

Off-Label Treatment in Inflammatory Skin Diseases—European Point of View DOI Open Access

Julia Sternicka,

Roman Nowicki, Leszek Bieniaszewski

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2376 - 2376

Published: March 30, 2025

Off-label treatment is the use of a drug approved for marketing, outside registration in terms indication, age group, dose or route administration. Despite constant appearance new preparations on market, SmPCs guidelines current clinical problem. It believed that it based needs patients unmet by classical therapy methods. This work focuses off-label inflammatory dermatoses such as atopic dermatitis, psoriasis, acne vulgaris and rosacea. Publications this subject, available PubMed, Google Scholar Cochrane Library, were analyzed form review, taking into account mechanisms action, efficacy safety preparations. Based literature analysis, can be concluded drugs SmPC indications common situation dermatology. However, difficult to determine its exact frequency-there lack data prevalence appliances from European perspective. demonstrate varying effectiveness therapy, depending specific preparation. dermatology remains an important issue should explored further research.

Language: Английский

Citations

0
Study of natto extract for the amelioration of dinitrochlorobenzene-induced atopic dermatitis by integrating untargeted metabolomics, network pharmacology, and molecular simulation DOI
Jin Wang,

Z.H.A.N.G. Li-Wen,

K.U.A.N.G. Zhe-Lin

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106510 - 106510

Published: April 1, 2025

Language: Английский

Citations

0
The diphenylpyrimidine derivative as a novel HDAC6 inhibitor alleviates atopic dermatitis through anti-inflammatory effects facilitated via TLR4/MAPK, STAT3 and NF-κB pathways DOI
Jinting Chen,

Hao Qiu,

Xin Ran

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108451 - 108451

Published: April 1, 2025

Language: Английский

Citations

0
Advancements in artificial intelligence for atopic dermatitis: diagnosis, treatment, and patient management DOI Creative Commons
Fang Cao,

Yujie Yang,

Cui Guo

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: April 8, 2025

Atopic dermatitis (AD) is a common and complex skin disease that significantly affects the quality of life patients. The latest advances in artificial intelligence (AI) technology have introduced new methods for diagnosing, treating, managing AD. AI has various innovative applications diagnosis treatment atopic dermatitis, with particular emphasis on its significant benefits medical diagnosis, monitoring, patient care. algorithms, especially those use deep learning techniques, demonstrate strong performance recognizing images effectively distinguishing different types lesions, including AD manifestations. In addition, also shown promise creating personalized plans, simplifying drug development processes, clinical trials. Despite challenges data privacy model transparency, potential advancing care enormous, bringing future to precision medicine improving outcomes. This manuscript provides comprehensive review application process first time, aiming play key role advancement health further enhance

Language: Английский

Citations

0
Advances in plant essential oils and drug delivery systems for skincare DOI Creative Commons
Yihan Wang,

Dou Jin-jin,

Wang Yingqi

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Background Essential oils, often referred to as “liquid gold,” are renowned for their broad biological activity. Ancient Egyptians used essential oils’ antibacterial and antiseptic effects preserve mummies, ancient Greeks olive oil sun protection, Chinese oils treat wounds. When applied the facial skin, potent anti-inflammatory, antioxidant, pharmacological characteristics provide various benefits, including sunscreen, skin-whitening, anti-aging effects. Purpose This paper aims summarize application of plant in skin whitening, antioxidant recent years, deeply analyzes internal relationship between modern drug delivery system, expounds how overcome limitations through specific enhance its activity stability, realize sustained release reduce potential toxicity, also discusses positive on brain function olfactory pathway, emphasizes possible safety risks use oil, puts forward corresponding suggestions use. Methods Using keywords such “essential oils,” “antioxidant,” “anti-tyrosinase,” Antibacterial Effects anti-inflammatory,” “anti-anxiety,” “drug carrier systems,” a comprehensive search was conducted PubMed, CNKI, Baidu, Wanfang databases articles from past 5 years. Further screening performed select studies demonstrating efficacy topical or external application. Results Various showed strong oxidants, agents, anti-inflammatory skin-whitening agents. Combined with new it not only enhances but reduces inherent defects volatility, irritation, has targeted effect. At same time, integration into care products can make dual functions smell epidermal system nourish repair maximize oil. Conclusion review delves systems, advocating broader natural resources technology. By strategically utilizing we promote sustainable development global economy. However, extensive clinical trials still required evaluate effectiveness systems.

Language: Английский

Citations

0
Nutritional and Microbial Strategies for Treating Acne, Alopecia, and Atopic Dermatitis DOI Open Access
Alejandro Borrego-Ruiz, Juan J. Borrego

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3559 - 3559

Published: Oct. 20, 2024

Diet is one of the major determinants composition and function gut microbiome, diverse studies have established directional connections between microbiome dysbiosis skin dyshomeostasis. Furthermore, a significant link certain skin-related disorders has been reported. This work reviews mechanisms underlying relationship nutritional factors, diseases such as acne vulgaris, alopecia, atopic dermatitis. In addition, it explores how modulation human through diet various microbial strategies, including probiotics, synbiotics, postbiotics, fecal microbiota transplantation, may serve future treatments for diseases, possibly replacing traditional methods antibiotic, topical corticosteroid, laser therapies.

Language: Английский

Citations

3
Advancements in the application of natural extracts for atopic dermatitis treatment DOI Creative Commons
Yi Peng,

Miaohong Yang,

Wen Ju

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(2), P. 100022 - 100022

Published: May 2, 2024

Atopic dermatitis, a common chronic inflammatory skin disease, has an unclear etiology and may involve multiple factors such as genetic predisposition, immune abnormalities, impaired barrier function. Currently, there is no specific medication available for the complete cure of atopic dermatitis. The current treatment approaches mainly focus on symptom relief control rather than curative treatment. Some commonly used medications topical corticosteroids immunosuppressants, have certain adverse reactions side effects. This review summarizes research progress natural extracts in aiming to provide foundation development safe side-effect-free medications.

Language: Английский

Citations

2
Atopic Dermatitis DOI
Nanette B. Silverberg

Dermatologic Clinics, Journal Year: 2024, Volume and Issue: 42(4), P. 635 - 638

Published: July 1, 2024

Language: Английский

Citations

2
Novel therapeutic receptor agonists and antagonists in allergic conjunctivitis DOI
Sampson Listowell Abu,

Navpreet K. Hehar,

DeGaulle I. Chigbu

et al.

Current Opinion in Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 24(5), P. 380 - 389

Published: July 22, 2024

Allergic conjunctivitis is characterized by the development of pathophysiological changes to ocular surface, which occurs when pro-allergic and pro-inflammatory mediators interact with their cognate receptors expressed on immune nonimmune cells. Traditional treatments antihistamines corticosteroids provide relief, but there a need for more efficacious tolerable long-term therapy better safety profile. This article aims an overview mode action clinical application agonist therapies targeting glucocorticoid, melanocortin, toll-like receptors, as well antagonist cytokine, chemokine, integrin, histamine receptors.

Language: Английский

Citations

2
Atopic dermatitis: pathogenesis and therapeutic intervention DOI Creative Commons
Chengcheng Yue, Hong Zhou,

Xiaoyan Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Dec. 1, 2024

Abstract The skin serves as the first protective barrier for nonspecific immunity and encompasses a vast network of skin‐associated immune cells. Atopic dermatitis (AD) is prevalent inflammatory disease that affects individuals all ages races, with complex pathogenesis intricately linked to genetic, environmental factors, dysfunction well dysfunction. Individuals diagnosed AD frequently exhibit genetic predispositions, characterized by mutations impact structural integrity barrier. This leads release alarmins, activating type 2 pathway recruiting various cells skin, where they coordinate cutaneous responses. In this review, we summarize experimental models provide an overview its therapeutic interventions. We focus on elucidating intricate interplay between system regulatory mechanisms, commonly used treatments AD, aiming systematically understand cellular molecular crosstalk in AD‐affected skin. Our overarching objective novel insights inform potential clinical interventions reduce incidence AD.

Language: Английский

Citations

2