International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13539 - 13539
Published: Dec. 18, 2024
Cannabichromene
(CBC)
is
one
of
the
main
cannabinoids
found
in
cannabis
plant,
and
although
less
well
known
than
tetrahydrocannabinol
(THC)
cannabidiol
(CBD),
it
gaining
attention
for
its
potential
therapeutic
benefits.
To
date,
CBC’s
mechanisms
action
include
anti-inflammatory,
analgesic,
antidepressant,
antimicrobial,
neuroprotective,
anti-acne
effects
through
TRP
channel
activation
inhibition
inflammatory
pathways,
suggesting
that
may
have
treatment
skin
diseases,
such
as
atopic
dermatitis
(AD),
but
exact
mechanism
remains
unclear.
Therefore,
this
study,
we
investigated
CBC
on
Th2
cytokines
along
with
Janus
kinase
(JAK)/signal
transducer
activator
transcription
(STAT)
pathways
involved
AD
pathogenesis.
We
used
a
2,4-Dinitrochlorobenzene
(DNCB)-induced
BALB/c
mouse
model
to
topically
administer
(0.1
mg/kg
or
1
mg/kg).
The
results
showed
lesion
severity,
ear
thickness,
epithelial
thickness
dorsal
skin,
mast
cell
infiltration
were
significantly
reduced
0.1
CBC-treated
group
compared
DNCB-treated
(p
<
0.001).
In
addition,
real-time
quantitative
reverse
polymerase
chain
reaction
(qRT-PCR)
analysis
significant
decrease
mRNA
expression
(TSLP,
IL-4,
IL-13)
mediators
(IFN-γ,
IL-1β,
IL-6,
IL-17,
IL-18,
IL-33)
0.05).
Western
blot
also
revealed
JAK1,
JAK2,
STAT1,
STAT2,
STAT3,
STAT6
protein
These
suggest
promising
candidate
demonstrates
alleviate
symptoms
by
suppressing
immune
response.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12827 - 12827
Published: Nov. 28, 2024
Environmental
pollutants,
particularly
volatile
organic
compounds
(VOCs),
are
associated
with
various
diseases,
including
atopic
dermatitis
(AD).
However,
despite
numerous
studies
on
AD,
there
is
a
lack
of
research
the
impact
environmental
exposures
mothers
and
infants.
This
study,
therefore,
investigated
effects
maternal
exposure
to
specific
VOCs
(toluene,
xylene,
benzene)
expression
AD-related
genes
in
their
RNA
levels
DNA
methylation
patterns
were
analyzed
examine
correlation
between
AD.
A
multi-omics
approach
integrating
gene
data
was
additionally
employed
gain
broader
understanding
genetic
VOC
exposure.
Network
analysis
revealed
significant
changes
For
example,
toluene
resulted
upregulation
AQP10,
which
linked
keratinocyte
dysfunction,
infants,
IL31RA
CCL20
notably
affected,
both
play
critical
roles
immune
response
skin
barrier
function.
In
exposed
histamine
receptor
HRH1
identified
as
key
player
influencing
AD
through
its
role
recovery,
while
infants
exhibited
consistent
network
responses
downregulation
TIGIT,
reflecting
shared
across
different
xylene
isomers.
Interestingly,
isomers
displayed
nearly
identical
patterns,
suggesting
developmental
resistance
diverse
factors.
No
benzene-exposed
group.
These
findings
suggest
that
may
have
related
highlighting
complexity
how
factors
contribute
disease
development.
Medical alphabet,
Journal Year:
2024,
Volume and Issue:
24, P. 16 - 22
Published: Dec. 5, 2024
Atopic
dermatitis
is
one
of
the
most
common
skin
diseases
in
children.
Genetic
disorders
that
determine
development
persistent
dysfunction
cellular
immunity
play
an
important
role
clinical
symptoms
atopic
dermatitis.
In
new
concept
occurrence
manifestations
(AD),
T-regulatory
lymphocytes
are
assigned,
form
CD4+CD25+
phenotype,
which
controlled
by
transcription
factor
FoxP3.
The
study
mechanism
itching,
more
or
less
observed
all
children
with
blood
pressure,
showed
case
island-inflammatory
course
Th2-dependent
itching
histamine-conditioned.
According
to
«Outside
Inside
–
outside
inside»,
significant
mechanisms
causing
appearance
pressure
a
genetic
predisposition
causes
formation
allergic
reactions,
changes
permeability
epidermal
barrier,
against
background
transepidermal
moisture
loss,
xerosis
phenomena
and
decrease
threshold.
Significant
abnormalities
state
microbiota
were
found
AD.
species
composition
intestinal
AD
differs
significantly
from
healthy
skin.
Intestinal
microbiocenosis
largely
determines
direction
morphofunctional
processes
epidermis,
means
translocation
bacteria
regulating
humoral
response
directly
Most
often,
reactions
triggered
when
food
proteins
enter
body.
Among
other
allergens,
cow’s
milk
protein
young
many
cases,
1-year-old
AD,
goat’s
mixtures
good
alternative
milk-based
mixtures.
At
present
stage,
complex
therapeutic
measures
first
year
life
diet
therapy
active
external
therapy,
including
phased
use
topical
steroids,
calcineurin
inhibitors,
emollients.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13539 - 13539
Published: Dec. 18, 2024
Cannabichromene
(CBC)
is
one
of
the
main
cannabinoids
found
in
cannabis
plant,
and
although
less
well
known
than
tetrahydrocannabinol
(THC)
cannabidiol
(CBD),
it
gaining
attention
for
its
potential
therapeutic
benefits.
To
date,
CBC’s
mechanisms
action
include
anti-inflammatory,
analgesic,
antidepressant,
antimicrobial,
neuroprotective,
anti-acne
effects
through
TRP
channel
activation
inhibition
inflammatory
pathways,
suggesting
that
may
have
treatment
skin
diseases,
such
as
atopic
dermatitis
(AD),
but
exact
mechanism
remains
unclear.
Therefore,
this
study,
we
investigated
CBC
on
Th2
cytokines
along
with
Janus
kinase
(JAK)/signal
transducer
activator
transcription
(STAT)
pathways
involved
AD
pathogenesis.
We
used
a
2,4-Dinitrochlorobenzene
(DNCB)-induced
BALB/c
mouse
model
to
topically
administer
(0.1
mg/kg
or
1
mg/kg).
The
results
showed
lesion
severity,
ear
thickness,
epithelial
thickness
dorsal
skin,
mast
cell
infiltration
were
significantly
reduced
0.1
CBC-treated
group
compared
DNCB-treated
(p
<
0.001).
In
addition,
real-time
quantitative
reverse
polymerase
chain
reaction
(qRT-PCR)
analysis
significant
decrease
mRNA
expression
(TSLP,
IL-4,
IL-13)
mediators
(IFN-γ,
IL-1β,
IL-6,
IL-17,
IL-18,
IL-33)
0.05).
Western
blot
also
revealed
JAK1,
JAK2,
STAT1,
STAT2,
STAT3,
STAT6
protein
These
suggest
promising
candidate
demonstrates
alleviate
symptoms
by
suppressing
immune
response.
