Cells,
Journal Year:
2024,
Volume and Issue:
14(1), P. 1 - 1
Published: Dec. 24, 2024
Inflammation
can
positively
and
negatively
affect
tumorigenesis
based
on
the
duration,
scope,
sequence
of
related
events
through
regulation
signaling
pathways.
A
transcriptomic
analysis
five
pulmonary
arterial
hypertension,
twelve
Crohn’s
disease,
ulcerative
colitis
high
throughput
sequencing
datasets
using
R
language
specialized
libraries
gene
enrichment
analyses
identified
a
regulatory
network
in
each
inflammatory
disease.
IRF9
LINC01089
hypertension
are
to
pathways
like
MAPK,
NOTCH,
human
papillomavirus,
hepatitis
c
infection.
ZNF91
TP53TG1
disease
PPAR,
metabolic
ZNF91,
VDR,
DLEU1,
SATB2-AS1,
AMPK,
The
activation
might
be
interaction
characteristic
microbiota
with
lung
gut
cell
receptors
present
membrane
rafts
complexes.
highlights
impact
several
coding
non-coding
RNAs,
suggesting
their
relationship
unlocking
phenotypic
plasticity
for
acquisition
hallmarks
cancer
during
adaptation
phenotypes.
Biology,
Journal Year:
2024,
Volume and Issue:
13(7), P. 519 - 519
Published: July 12, 2024
Glycolipid
metabolic
disorders
(GLMDs)
are
various
resulting
from
dysregulation
in
glycolipid
levels,
consequently
leading
to
an
increased
risk
of
obesity,
diabetes,
liver
dysfunction,
neuromuscular
complications,
and
cardiorenal
vascular
diseases
(CRVDs).
In
patients
with
GLMDs,
excess
caloric
intake
a
lack
physical
activity
may
contribute
oxidative
stress
(OxS)
systemic
inflammation.
This
study
aimed
review
the
connection
between
GLMD,
OxS,
metainflammation,
onset
CRVD.
GLMD
is
due
causing
dysfunction
synthesis,
breakdown,
absorption
glucose
lipids
body,
excessive
ectopic
accumulation
these
molecules.
mainly
neuroendocrine
dysregulation,
insulin
resistance,
metainflammation.
many
inflammatory
markers
defense
cells
play
vital
role
related
tissues
organs,
such
as
blood
vessels,
pancreatic
islets,
liver,
muscle,
kidneys,
adipocytes,
promoting
lesions
that
affect
interconnected
organs
through
their
signaling
pathways.
Advanced
glycation
end
products,
ATP-binding
cassette
transporter
1,
Glucagon-like
peptide-1,
Toll-like
receptor-4,
sphingosine-1-phosphate
(S1P)
crucial
since
they
glucolipid
metabolism.
The
consequences
this
system
organ
damage
morbidity
mortality.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 6, 2025
Abstract
The
purpose
of
this
study
was
to
investigate
how
Sphingosine-1-phosphate
(S1P)
signaling
regulates
glial
phenotype,
neuroprotection,
and
reprogramming
Müller
glia
(MG)
into
neurogenic
MG-derived
progenitor
cells
(MGPCs)
in
the
adult
mouse
retina.
We
found
that
S1P-related
genes
were
dynamically
regulated
following
retinal
damage.
S1pr1
(encoding
S1P
receptor
1)
Sphk1
sphingosine
kinase
are
expressed
at
low
levels
by
resting
MG
rapidly
upregulated
acute
Overexpression
bHLH
transcription
factor
Ascl1
downregulates
,
inhibition
S1pr1/3
enhances
Ascl1-driven
differentiation
bipolar-like
suppresses
differentiation.
Treatments
activate
or
increase
initiate
pro-inflammatory
NFκB-signaling
MG,
whereas
treatments
inhibit
decreased
suppress
damaged
retinas.
Conditional
knock-out
increases
expression
but
decreases
S1pr3
.
(cKO)
not
accumulation
immune
acutely
cKO
i
s
neuroprotective
ganglion
cells,
is
amacrine
NMDA-damaged
Consistent
with
these
findings,
pharmacological
receptors
had
protective
effects
upon
inner
neurons.
conclude
S1P-signaling
pathway
activated
after
damage
acts
secondarily
restrict
impairs
neuron
survival
progenitors
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 14, 2025
Macrophages,
crucial
innate
immune
cells,
defend
against
pathogens
and
resolve
inflammation,
maintaining
tissue
balance.
They
perform
phagocytosis,
present
antigens
to
T
bond
adaptive
immunity
through
various
activation
states.
Classical
is
associated
with
Th1
responses
interferon
γ
production,
while
alternative
activation,
induced
by
interleukin
4,
characterized
increased
endocytosis,
reduced
secretion
of
pro-inflammatory
cytokines,
roles
in
immunoregulation
remodeling.
Although
these
represent
opposite
extremes
observed
vitro
,
the
remarkable
plasticity
macrophages
allows
for
a
wide
spectrum
phenotypes
that
are
complex
characterize
experimentally.
While
application
omics
techniques
has
resulted
significant
advances
characterization
macrophage
polarization,
lipidomic
studies
have
received
lesser
attention.
Beyond
their
role
as
structural
components
energy
sources,
lipids
function
signaling
molecules
regulate
thereby
shaping
responses.
This
work
reviews
interaction
between
lipid
exploring
how
metabolism
influences
phenotype
function.
These
insights
offer
potential
therapeutic
strategies
immune-mediated
diseases
inflammation-related
disorders,
including
inflammaging.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11474 - 11474
Published: Oct. 25, 2024
Sphingosine-1-phosphate
(S1P)
is
a
sphingolipid
metabolic
product
produced
via
the
phosphorylation
of
sphingosine
by
kinases
(SPHKs),
serving
as
powerful
modulator
various
cellular
processes
through
its
interaction
with
S1P
receptors
(S1PRs).
Currently,
this
incompletely
understood
mechanism
in
pancreatic
diseases
including
pancreatitis
and
cancer,
largely
limits
therapeutic
options
for
these
disorders.
Recent
evidence
indicates
that
significantly
contributes
to
modulating
inflammation,
promoting
pyroptosis
acinar
cells,
regulating
activation
stellate
affecting
organelle
functions
cancer
cells.
Nevertheless,
no
review
has
encapsulated
advancements.
Thus,
compiles
information
about
involvement
signaling
exocrine
disorders,
acute
pancreatitis,
chronic
well
prospective
treatment
strategies
target
conditions.
The
insights
presented
here
possess
potential
offer
valuable
guidance
implementation
therapies
targeting
diseases.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Sept. 30, 2024
Mitochondria
play
a
crucial
role
in
shaping
the
macrophage
inflammatory
response
during
bacterial
infections.
Spinster
homolog
2
(Spns2),
responsible
for
sphingosine-1-phosphate
(S1P)
secretion,
acts
as
key
regulator
of
mitochondrial
dynamics
macrophages.
However,
link
between
Spns2/S1P
signaling
and
functions
remains
unclear.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1322 - 1322
Published: Oct. 30, 2024
The
impact
of
ionizing
radiation
on
the
male
reproductive
system
is
gaining
increasing
attention,
particularly
when
it
comes
to
testicular
damage,
which
may
result
in
decreased
sperm
quality
and
hormonal
imbalances.
Finding
effective
protective
measures
mitigate
damage
caused
by
has
become
a
focal
point
biomedical
field.
S1P,
an
essential
biological
signaling
molecule,
garnered
significant
interest
due
its
multiple
roles
regulating
cellular
functions
effects
against
radiation-induced
injury.
S1P
not
only
effectively
reduces
generation
ROS
induced
but
also
alleviates
oxidative
stress
enhancing
activity
antioxidant
enzymes.
Furthermore,
inhibits
cell
apoptosis
expression
anti-apoptotic
pro-apoptotic
proteins.
Additionally,
inflammation
inhibiting
production
inflammatory
factors,
thereby
further
protecting
tissue.
In
summary,
through
mechanisms,
offering
promising
therapeutic
approach
safeguard
health.
Future
research
should
explore
specific
mechanisms
action
clinical
application
potential
aiming
contribute
significantly
prevention
treatment
damage.
Journal of Multidisciplinary Healthcare,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 5117 - 5137
Published: Nov. 1, 2024
Cancer
poses
a
major
global
health
challenge,
and
immunotherapy,
known
as
the
third
revolution
in
cancer
treatment,
has
brought
new
hope
to
patients.
The
emerging
field
of
immunometabolism
further
enhanced
safety
efficacy
immunotherapy.
Over
past
two
decades,
this
rapidly
evolved
oncology,
leading
numerous
significant
findings.
This
review
systematically
examines
literature
on
cancer,
visualizing
research
trends
identifying
future
directions.
